ES8306376A1 - Procedimiento para preparar acidos penicilanicos 6-sustituidos. - Google Patents
Procedimiento para preparar acidos penicilanicos 6-sustituidos.Info
- Publication number
- ES8306376A1 ES8306376A1 ES509424A ES509424A ES8306376A1 ES 8306376 A1 ES8306376 A1 ES 8306376A1 ES 509424 A ES509424 A ES 509424A ES 509424 A ES509424 A ES 509424A ES 8306376 A1 ES8306376 A1 ES 8306376A1
- Authority
- ES
- Spain
- Prior art keywords
- mixture
- dioxo
- alkyl
- ethyl acetate
- conditions
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- AVKUERGKIZMTKX-NJBDSQKTSA-N ampicillin Chemical class C1([C@@H](N)C(=O)N[C@H]2[C@H]3SC([C@@H](N3C2=O)C(O)=O)(C)C)=CC=CC=C1 AVKUERGKIZMTKX-NJBDSQKTSA-N 0.000 title abstract 2
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 abstract 6
- 239000000203 mixture Substances 0.000 abstract 2
- 239000011541 reaction mixture Substances 0.000 abstract 2
- 229960000723 ampicillin Drugs 0.000 abstract 1
- 230000003115 biocidal effect Effects 0.000 abstract 1
- 150000004820 halides Chemical class 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- RBKMMJSQKNKNEV-RITPCOANSA-N penicillanic acid Chemical compound OC(=O)[C@H]1C(C)(C)S[C@@H]2CC(=O)N21 RBKMMJSQKNKNEV-RITPCOANSA-N 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- 239000000725 suspension Substances 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cephalosporin Compounds (AREA)
Abstract
PROCEDIMIENTO PARA PREPARAR ACIDOS PENICILANICOS 6-SUSTITUIDOS, EN PARTICULAR PARA PREPARAR UN ACIDO 6- D(-)-ALFA-(4-C -C ALQUIL-2,3-DIOXO-1-PIPERAZINOCARBONILAMINO)- FENILACETAMIDO PENICILANICO. COMPRENDE LAS SIGUIENTES OPERACIONES: PRIMERA, A UNA SUSPENSION DE AMPICILINA EN UNA MEZCLA DE ACETATO DE ETILO Y AGUA, EN PRESENCIA DE UNA BASE, SE LE AÑADE UN HALURO DE 4-ALQUIL (C -C )-2,3-DIOXO-1-PIPERAZINOCARBONILO, PARA FORMAR UNA MEZCLA DE REACCION; SEGUNDA, DICHA MEZCLA DE REACCION SE AGITA HASTA QUE HAYA FINALIZADO DICHA REACCION; Y POR ULTIMO, SE ACIDIFICA LA MEZCLA DE REACCION Y SE RECUPERA EL PRODUCTO CRISTALINO FORMADO. DE APLICACION COMO ANTIBIOTICOS PARA EL TRATAMIENTO DE NEUMONIA, PERITONITIS O INFECCIONES DEL SISTEMA SANGUINEO.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US24875481A | 1981-03-30 | 1981-03-30 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES8306376A1 true ES8306376A1 (es) | 1983-06-01 |
| ES509424A0 ES509424A0 (es) | 1983-06-01 |
Family
ID=22940531
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES509424A Granted ES509424A0 (es) | 1981-03-30 | 1982-02-08 | Procedimiento para preparar acidos penicilanicos 6-sustituidos. |
Country Status (23)
| Country | Link |
|---|---|
| JP (1) | JPS57165391A (es) |
| AT (1) | AT381706B (es) |
| AU (1) | AU544896B2 (es) |
| BE (1) | BE892586A (es) |
| CA (1) | CA1200239A (es) |
| CH (1) | CH654309A5 (es) |
| DE (1) | DE3208506A1 (es) |
| DK (1) | DK161079C (es) |
| ES (1) | ES509424A0 (es) |
| FR (1) | FR2502623A1 (es) |
| GB (1) | GB2095661B (es) |
| GR (1) | GR76054B (es) |
| HK (1) | HK23590A (es) |
| IE (1) | IE52907B1 (es) |
| IL (1) | IL64981A (es) |
| IT (1) | IT1148130B (es) |
| LU (1) | LU84036A1 (es) |
| NL (2) | NL192453C (es) |
| NZ (1) | NZ199869A (es) |
| PH (1) | PH19765A (es) |
| PL (1) | PL235508A1 (es) |
| SE (1) | SE452767B (es) |
| ZA (1) | ZA82674B (es) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BG46664A1 (en) * | 1985-08-16 | 1990-02-15 | Druzhestven N Izsledovatelski | Method for preparing of 6- /d (-)- alpha- (4- ethyl- 2, 3- dioxo- 1- piperazine carbonylamino)- phenylacetamido/- penicillanic acid |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL47168A (en) * | 1974-05-09 | 1979-07-25 | Toyama Chemical Co Ltd | Mono or dioxo piperazino(thio)carbonylamino derivatives ofpenicillins and cephalosporins and process for producing the same |
| US4087424A (en) * | 1974-05-09 | 1978-05-02 | Toyama Chemical Co., Ltd. | Novel penicillins and cephalosporins and process for producing the same |
| US4112090A (en) * | 1974-05-09 | 1978-09-05 | Toyama Chemical Co., Ltd. | Novel penicillins and cephalosporins and process for producing the same |
-
1982
- 1982-01-28 CA CA000395121A patent/CA1200239A/en not_active Expired
- 1982-01-29 AU AU79964/82A patent/AU544896B2/en not_active Expired
- 1982-01-29 GB GB8202662A patent/GB2095661B/en not_active Expired
- 1982-02-02 ZA ZA82674A patent/ZA82674B/xx unknown
- 1982-02-03 GR GR67199A patent/GR76054B/el unknown
- 1982-02-04 DK DK048282A patent/DK161079C/da active
- 1982-02-08 ES ES509424A patent/ES509424A0/es active Granted
- 1982-02-11 IL IL64981A patent/IL64981A/xx unknown
- 1982-02-17 PH PH26877A patent/PH19765A/en unknown
- 1982-02-22 JP JP57026170A patent/JPS57165391A/ja active Granted
- 1982-03-01 NZ NZ199869A patent/NZ199869A/en unknown
- 1982-03-09 AT AT0093082A patent/AT381706B/de not_active IP Right Cessation
- 1982-03-09 DE DE19823208506 patent/DE3208506A1/de active Granted
- 1982-03-10 IT IT47962/82A patent/IT1148130B/it active
- 1982-03-17 FR FR8204497A patent/FR2502623A1/fr active Granted
- 1982-03-18 PL PL23550882A patent/PL235508A1/xx unknown
- 1982-03-22 BE BE0/207631A patent/BE892586A/fr not_active IP Right Cessation
- 1982-03-24 LU LU84036A patent/LU84036A1/de unknown
- 1982-03-26 CH CH1898/82A patent/CH654309A5/de not_active IP Right Cessation
- 1982-03-29 SE SE8201998A patent/SE452767B/sv not_active IP Right Cessation
- 1982-03-29 NL NL8201301A patent/NL192453C/nl not_active IP Right Cessation
- 1982-03-29 NL NL192453D patent/NL192453A/xx not_active IP Right Cessation
- 1982-03-29 IE IE746/82A patent/IE52907B1/en not_active IP Right Cessation
-
1990
- 1990-03-29 HK HK235/90A patent/HK23590A/xx not_active IP Right Cessation
Also Published As
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