ES8305735A1 - Procedimiento para la preparacion de derivados de la metil-4 fenil-6 piridazina. - Google Patents

Procedimiento para la preparacion de derivados de la metil-4 fenil-6 piridazina.

Info

Publication number
ES8305735A1
ES8305735A1 ES514854A ES514854A ES8305735A1 ES 8305735 A1 ES8305735 A1 ES 8305735A1 ES 514854 A ES514854 A ES 514854A ES 514854 A ES514854 A ES 514854A ES 8305735 A1 ES8305735 A1 ES 8305735A1
Authority
ES
Spain
Prior art keywords
methyl
phenyl
nervous system
central nervous
pyridazine derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES514854A
Other languages
English (en)
Other versions
ES514854A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi SA
Original Assignee
Sanofi SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi SA filed Critical Sanofi SA
Publication of ES8305735A1 publication Critical patent/ES8305735A1/es
Publication of ES514854A0 publication Critical patent/ES514854A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D237/22—Nitrogen and oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D237/20—Nitrogen atoms

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS DE LA METIL-4-FENIL-6 PIRIDAZINA, DE FORMULA (I), EN LA QUE R ES HIDROGENO O HIDROXI; Y R PUEDE SER UNO DE VARIOS TIPOS DE RADICALES. CONSISTE EN LA REACCION DE CLORO-3 PIRIDAZINA CON UN COMPUESTO DE FORMULA NH -CH -CH -NY-CH -CH -OX, EN LA QUE X ES HIDROGENO E Y ES HIDROGENO O ALQUILO INFERIOR, O X E Y JUNTOS CONSTITUYEN UN RADICAL ETILENO. LA REACCION SE LLEVA A CABO EN UN DISOLVENTE INERTE TAL COMO UN ALCOHOL, EN PRESENCIA DE UN ACEPTOR DEL ACIDO CLORHIDRICO FORMADO, A UNA TEMPERATURA PROXIMA A LA DE EBULLICION DEL DISOLVENTE. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS POR SU ACTIVIDAD SOBRE EL SISTEMA NERVIOSO CENTRA
ES514854A 1981-08-10 1982-08-09 Procedimiento para la preparacion de derivados de la metil-4 fenil-6 piridazina. Granted ES514854A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8115435A FR2510997A1 (fr) 1981-08-10 1981-08-10 Nouveaux derives de la methyl-4 phenyl-6 pyridazine, procede pour leur preparation et medicaments actifs sur le systeme nerveux central en contenant

Publications (2)

Publication Number Publication Date
ES8305735A1 true ES8305735A1 (es) 1983-05-01
ES514854A0 ES514854A0 (es) 1983-05-01

Family

ID=9261319

Family Applications (1)

Application Number Title Priority Date Filing Date
ES514854A Granted ES514854A0 (es) 1981-08-10 1982-08-09 Procedimiento para la preparacion de derivados de la metil-4 fenil-6 piridazina.

Country Status (29)

Country Link
US (3) US4576946A (es)
EP (1) EP0072299B1 (es)
JP (1) JPS5838262A (es)
KR (1) KR880002710B1 (es)
AT (1) ATE24317T1 (es)
AU (1) AU548029B2 (es)
CA (1) CA1180704A (es)
CS (1) CS241052B2 (es)
DD (3) DD213212A5 (es)
DE (1) DE3274737D1 (es)
DK (1) DK148654C (es)
EG (1) EG15922A (es)
ES (1) ES514854A0 (es)
FI (1) FI74462C (es)
FR (1) FR2510997A1 (es)
GR (1) GR76235B (es)
HU (1) HU190695B (es)
IE (1) IE53611B1 (es)
IL (1) IL66423A0 (es)
MA (1) MA19561A1 (es)
NO (1) NO157141C (es)
NZ (1) NZ201530A (es)
OA (1) OA07178A (es)
PH (1) PH17883A (es)
PL (3) PL137265B1 (es)
PT (1) PT75371B (es)
SU (2) SU1366056A3 (es)
YU (3) YU171782A (es)
ZA (1) ZA825516B (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2539741A1 (fr) * 1983-01-21 1984-07-27 Sanofi Sa Composes a noyau heterocyclique diazote, leur procede de preparation et les medicaments, actifs sur le systeme nerveux central, qui en contiennent
FR2540113A1 (fr) * 1983-01-27 1984-08-03 Sanofi Sa Acides derives de la pyridazine actifs sur le systeme nerveux central
US4565814A (en) * 1983-01-28 1986-01-21 Sanofi Pyridazine derivatives having a psychotropic action and compositions
FR2601011B1 (fr) * 1986-07-03 1988-10-28 Sanofi Sa Nouveaux derives tricycliques agonistes des recepteurs cholinergiques et medicaments en contenant
US5106973A (en) * 1987-11-23 1992-04-21 Janssen Pharmaceutica N.V. Pyridzainamine derivatives
FR2642648B1 (fr) * 1989-02-07 1991-06-21 Sanofi Sa Utilisation de derives d'alkyl-5 pyridazine comme medicaments actifs sur le systeme cholinergique
US5656631A (en) * 1989-02-07 1997-08-12 Sanofi Pyridazine derivatives
PT93060B (pt) 1989-02-07 1995-12-29 Sanofi Sa Processo para a obtencao de derivados de piridazina e de composicoes farmaceuticas que os contem
JP3553142B2 (ja) * 1994-07-29 2004-08-11 花王株式会社 ４級アンモニウム塩の製造方法及び中間体ジアミノアルコール
CA2564996A1 (en) * 2004-05-08 2006-01-12 Taeyoung Yoon 3-aryl-5,6-disubstituted pyridazines
EP1741709A1 (en) * 2005-06-28 2007-01-10 Sanofi-Aventis Deutschland GmbH Heteroaryl-substituted amides comprising a saturated linker group, and their use as pharmaceuticals
US9133123B2 (en) 2010-04-23 2015-09-15 Cytokinetics, Inc. Certain amino-pyridines and amino-triazines, compositions thereof, and methods for their use
AR081331A1 (es) 2010-04-23 2012-08-08 Cytokinetics Inc Amino- pirimidinas composiciones de las mismas y metodos para el uso de los mismos
AR081626A1 (es) * 2010-04-23 2012-10-10 Cytokinetics Inc Compuestos amino-piridazinicos, composiciones farmaceuticas que los contienen y uso de los mismos para tratar trastornos musculares cardiacos y esqueleticos
MA41598A (fr) * 2015-02-25 2018-01-02 Constellation Pharmaceuticals Inc Composés thérapeutiques de pyridazine et leurs utilisations
AR119731A1 (es) 2019-05-17 2022-01-05 Novartis Ag Inhibidores del inflamasoma nlrp3

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1345880A (en) * 1971-06-18 1974-02-06 Cepbepe Pyridazine derivatives
FR2388799A1 (fr) * 1977-04-28 1978-11-24 Rolland Sa A Derives de pyridazinone, leur procede de preparation et leur application comme medicaments

Also Published As

Publication number Publication date
PL137265B1 (en) 1986-05-31
PT75371A (en) 1982-09-01
DK148654B (da) 1985-08-26
PL243376A1 (en) 1984-04-24
OA07178A (fr) 1984-04-30
FI822767A0 (fi) 1982-08-09
EG15922A (en) 1986-06-30
ES514854A0 (es) 1983-05-01
ATE24317T1 (de) 1987-01-15
NO157141C (no) 1988-01-27
PT75371B (en) 1984-12-10
PL243377A1 (en) 1984-04-24
AU8661982A (en) 1983-02-17
IE821821L (en) 1983-02-10
DD213213A5 (de) 1984-09-05
DD209453A5 (de) 1984-05-09
FR2510997A1 (fr) 1983-02-11
NZ201530A (en) 1985-05-31
DE3274737D1 (en) 1987-01-29
NO157141B (no) 1987-10-19
CS591282A2 (en) 1985-06-13
NO822705L (no) 1983-02-11
FI822767L (fi) 1983-02-11
US4576946A (en) 1986-03-18
US4514397A (en) 1985-04-30
JPS5838262A (ja) 1983-03-05
FR2510997B1 (es) 1984-02-10
GR76235B (es) 1984-08-04
AU548029B2 (en) 1985-11-21
US4677106A (en) 1987-06-30
CA1180704A (en) 1985-01-08
PH17883A (en) 1985-01-21
SU1356961A3 (ru) 1987-11-30
PL137201B1 (en) 1986-05-31
KR840001146A (ko) 1984-03-28
YU171782A (en) 1985-04-30
IE53611B1 (en) 1988-12-21
KR880002710B1 (ko) 1988-12-26
IL66423A0 (en) 1982-11-30
EP0072299A2 (fr) 1983-02-16
DK357482A (da) 1983-02-11
DK148654C (da) 1986-02-17
HU190695B (en) 1986-10-28
DD213212A5 (de) 1984-09-05
CS241052B2 (en) 1986-03-13
FI74462C (fi) 1988-02-08
SU1366056A3 (ru) 1988-01-07
YU209784A (en) 1985-04-30
EP0072299B1 (fr) 1986-12-17
PL237837A1 (en) 1984-05-07
FI74462B (fi) 1987-10-30
EP0072299A3 (en) 1984-01-11
ZA825516B (en) 1983-06-29
PL137262B1 (en) 1986-05-31
YU209684A (en) 1985-04-30
JPH0417950B2 (es) 1992-03-26
MA19561A1 (fr) 1983-04-01

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19970401