ES8302026A1 - Procedimiento para la preparacion de 11-metilen- 15-esteroi-des - Google Patents
Procedimiento para la preparacion de 11-metilen- 15-esteroi-desInfo
- Publication number
- ES8302026A1 ES8302026A1 ES506742A ES506742A ES8302026A1 ES 8302026 A1 ES8302026 A1 ES 8302026A1 ES 506742 A ES506742 A ES 506742A ES 506742 A ES506742 A ES 506742A ES 8302026 A1 ES8302026 A1 ES 8302026A1
- Authority
- ES
- Spain
- Prior art keywords
- steroids
- preparation
- compound
- delta
- methylene
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000000034 method Methods 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 150000003431 steroids Chemical class 0.000 title 1
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 abstract 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 abstract 3
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 abstract 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- KZBUYRJDOAKODT-UHFFFAOYSA-N Chlorine Chemical compound ClCl KZBUYRJDOAKODT-UHFFFAOYSA-N 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 239000000460 chlorine Substances 0.000 abstract 1
- 229960004132 diethyl ether Drugs 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 150000007522 mineralic acids Chemical class 0.000 abstract 1
- 150000007524 organic acids Chemical class 0.000 abstract 1
- 235000005985 organic acids Nutrition 0.000 abstract 1
- 239000002798 polar solvent Substances 0.000 abstract 1
- 230000001681 protective effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0051—Estrane derivatives
- C07J1/0081—Substituted in position 17 alfa and 17 beta
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0051—Estrane derivatives
- C07J1/0059—Estrane derivatives substituted in position 17 by a keto group
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0051—Estrane derivatives
- C07J1/0081—Substituted in position 17 alfa and 17 beta
- C07J1/0088—Substituted in position 17 alfa and 17 beta the substituent in position 17 alfa being an unsaturated hydrocarbon group
- C07J1/0096—Alkynyl derivatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J21/005—Ketals
- C07J21/006—Ketals at position 3
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P33/00—Preparation of steroids
- C12P33/06—Hydroxylating
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Chemical & Material Sciences (AREA)
- Microbiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
_(PROCEDIMIENTO PARA LA PREPARACION DE LL-METILEN-<019> -ESTEROIDES . SE HACE REACCIONAR SOBRE UN COMPUESTO 17 OXO-ESTEROIDE, UN COMPUESTO ETILINICO, CLORO ETINILICO O PROPINILICO ORGANOMETALICO DE FORMULA R -M, EN PRESENCIA DE UN DISOLVENTE INERTE TAL COMO DIETILETER, TETRAHIDROFURANO, DIOXANO, BENCENO O TOLUENO A UNA TEMPERATURA DE -78<025>C A 50<025>C. ANTES O DESPUES DE LA ESTERIFICACION, SE HIDROLIZA EL GRUPO PROTECTOR DE 3-OXO CON ACIDOS INORGANICOS U ORGANICOS EN PRESENCIA DE UN DISOLVENTE POLAR TAL COMO METANOL, ETANOL O ACETONA A TEMPERATURAS DE 20 A 100<025>C. SE OBTIENE EL COMPUESTO DE FORMULA GENERAL (I).
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19803042529 DE3042529A1 (de) | 1980-11-07 | 1980-11-07 | 11-methylen- (delta)(pfeil hoch)1(pfeil hoch)(pfeil hoch)5(pfeil hoch) -steroide, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate |
Publications (2)
Publication Number | Publication Date |
---|---|
ES8302026A1 true ES8302026A1 (es) | 1983-02-01 |
ES506742A0 ES506742A0 (es) | 1983-02-01 |
Family
ID=6116503
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES506742A Granted ES506742A0 (es) | 1980-11-07 | 1981-10-30 | Procedimiento para la preparacion de 11-metilen- 15-esteroi-des |
Country Status (6)
Country | Link |
---|---|
US (1) | US4371529A (es) |
EP (1) | EP0051762B1 (es) |
JP (1) | JPS57108100A (es) |
AT (1) | ATE10847T1 (es) |
DE (2) | DE3042529A1 (es) |
ES (1) | ES506742A0 (es) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5236913A (en) * | 1985-07-24 | 1993-08-17 | Akzo N.V. | 11-methylene-oestr-15-enes, processes for their preparation, and pharmaceutical compositions |
IE58562B1 (en) * | 1985-07-24 | 1993-10-06 | Akzo Nv | Novel 11-methylene-oestr-15-enes, processes for their preparation, and pharmaceutical compositions |
DE3723788A1 (de) * | 1987-07-16 | 1989-01-26 | Schering Ag | 11(beta)-phenyl-4,9,15-estratriene, deren herstellung und diese enthaltende pharmazeutische praeparate |
AU625450B2 (en) * | 1987-07-16 | 1992-07-09 | Schering Aktiengesellschaft Berlin Und Bergkamen | 11beta-phenyl-4,9,15-estratrienes, their manufacture, and pharmaceutical preparations containing them |
DE4232521A1 (de) * | 1992-09-22 | 1994-03-24 | Schering Ag | Gestagen wirksame 4,5;11,12-Estradiene, Verfahren zu ihrer Herstellung, diese Estradiene enthaltende Arzneimittel sowie deren Verwendung zur Herstellung von Arzneimitteln |
WO2002062391A2 (en) * | 2001-02-02 | 2002-08-15 | Pharmacia Corporation | Method of using a cyclooxygenase-2 inhibitor and sex steroids as a combination therapy for the treatment and prevention of dismenorrhea |
HUP0301332A3 (en) * | 2003-05-14 | 2006-04-28 | Richter Gedeon Vegyeszet | New mono-and bismethylene steroid derivatives and process for their synthesis and pharmaceutical compositions containing them |
EP2354150A1 (en) * | 2010-02-09 | 2011-08-10 | Laboratoire Theramex | Process for the preparation of gestodene |
CN105237605B (zh) * | 2014-07-11 | 2019-01-25 | 上海迪赛诺生物医药有限公司 | 一种用于合成孕二烯酮的中间体及其制备方法和应用 |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3475463A (en) * | 1966-07-11 | 1969-10-28 | Sterling Drug Inc | 15,16-unsaturated 19-norsteroids and their preparation |
US3927046A (en) * | 1972-12-09 | 1975-12-16 | Akzona Inc | Novel 11,11-alkylidene steroids |
DE2636405C2 (de) * | 1976-08-12 | 1982-07-08 | Schering Ag, 1000 Berlin Und 4619 Bergkamen | Δ↑1↑↑5↑-17α-Chloräthinyl- und -Propinylsteroide der Östranreihe, Verfahren zu ihrer Herstellung sowie diese enthaltende pharmazeutische Präparate |
DE2636404C2 (de) * | 1976-08-12 | 1983-12-08 | Schering AG, 1000 Berlin und 4709 Bergkamen | Δ↑1↑↑5↑-17α-Äthinylsteroide der Östranreihe, Verfahren zu ihrer Herstellung sowie diese enthaltende pharmazeutische Präparate |
US4081537A (en) * | 1975-10-10 | 1978-03-28 | Schering Aktiengesellschaft | Δ15 -Steroids and pharmaceutical compositions thereof |
DE2636407A1 (de) * | 1976-08-12 | 1978-02-16 | Schering Ag | Delta hoch 15 -steroide |
DE2913381A1 (de) * | 1979-03-30 | 1980-10-16 | Schering Ag | 11-methylensteroide, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate |
DE3546062A1 (de) * | 1985-12-24 | 1987-06-25 | Stratec Elektronik Gmbh | Ortsempfindliches proportional-zaehlrohr hoher aufloesung |
-
1980
- 1980-11-07 DE DE19803042529 patent/DE3042529A1/de not_active Withdrawn
-
1981
- 1981-10-17 EP EP81108466A patent/EP0051762B1/de not_active Expired
- 1981-10-17 DE DE8181108466T patent/DE3167863D1/de not_active Expired
- 1981-10-17 AT AT81108466T patent/ATE10847T1/de not_active IP Right Cessation
- 1981-10-30 ES ES506742A patent/ES506742A0/es active Granted
- 1981-11-05 JP JP56176576A patent/JPS57108100A/ja active Granted
- 1981-11-06 US US06/318,906 patent/US4371529A/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
EP0051762A1 (de) | 1982-05-19 |
DE3042529A1 (de) | 1982-06-24 |
US4371529A (en) | 1983-02-01 |
DE3167863D1 (en) | 1985-01-31 |
EP0051762B1 (de) | 1984-12-19 |
ES506742A0 (es) | 1983-02-01 |
JPH027959B2 (es) | 1990-02-21 |
ATE10847T1 (de) | 1985-01-15 |
JPS57108100A (en) | 1982-07-05 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD1A | Patent lapsed |
Effective date: 19971001 |