ES472708A1 - Procedimiento para la preparacion de derivados de bromhexina - Google Patents
Procedimiento para la preparacion de derivados de bromhexinaInfo
- Publication number
- ES472708A1 ES472708A1 ES472708A ES472708A ES472708A1 ES 472708 A1 ES472708 A1 ES 472708A1 ES 472708 A ES472708 A ES 472708A ES 472708 A ES472708 A ES 472708A ES 472708 A1 ES472708 A1 ES 472708A1
- Authority
- ES
- Spain
- Prior art keywords
- bromhexine
- making same
- derivatives
- image
- general formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/02—Preparation of carboxylic acid amides from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/12—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by halogen atoms or by nitro or nitroso groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
Procedimiento para la preparación de derivados de bromhexina de la fórmula: **(Fórmula)** caracterizado porque comprende clorar, el ácido carboxílico correspondiente y, a continuación, hacer reaccionar bromhexina con un exceso del cloruro de ácido carboxílico así obtenido en presencia de un disolvente apropiado a la temperatura de reflujo.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT23931/78A IT1094864B (it) | 1978-05-29 | 1978-05-29 | Derivati della bromexina e procedimento per la loro preparazione |
Publications (1)
Publication Number | Publication Date |
---|---|
ES472708A1 true ES472708A1 (es) | 1979-10-16 |
Family
ID=11210963
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES472708A Expired ES472708A1 (es) | 1978-05-29 | 1978-08-21 | Procedimiento para la preparacion de derivados de bromhexina |
Country Status (4)
Country | Link |
---|---|
US (1) | US4191780A (es) |
DE (1) | DE2835043A1 (es) |
ES (1) | ES472708A1 (es) |
IT (1) | IT1094864B (es) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU574360B2 (en) * | 1983-05-13 | 1988-07-07 | Reichert, D. | Antisnoring agent |
JPS6272657A (ja) * | 1985-09-27 | 1987-04-03 | Terumo Corp | アミド誘導体およびこれを含有する5−リポキシゲナ−ゼ作用阻害剤 |
IT1248702B (it) * | 1990-06-06 | 1995-01-26 | Yason Srl | Agente antitussivo e mucoregolatore,sua preparazione e composizioni farmaceutiche |
WO2008033466A2 (en) * | 2006-09-14 | 2008-03-20 | Combinatorx (Singapore) Pre. Ltd. | Compositions and methods for treatment of viral diseases |
EP3415143A1 (en) * | 2017-06-16 | 2018-12-19 | Kai-Uwe Kern | Bromhexine for the treatment of pain |
CN114644572B (zh) * | 2022-03-22 | 2023-03-28 | 华南农业大学 | 一种溴己新半抗原、人工抗原、抗体及其制备方法和应用 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2337456A1 (de) * | 1973-07-24 | 1975-04-17 | Thomae Gmbh Dr K | Neues verfahren zur herstellung von 2-acylamino-benzylaminen |
US3985804A (en) * | 1973-08-18 | 1976-10-12 | Kumiai Chemical Industry Co., Ltd. | Agricultural substituted 2-methylbenzanilide germicide |
DE2525855C3 (de) * | 1974-06-12 | 1978-06-22 | Kumiai Chemical Industry Co., Ltd., Tokio | Substituierte Benzoesäureanilide sowie ein diese Verbindungen enthaltendes Mittel |
US3917696A (en) * | 1974-09-20 | 1975-11-04 | Lab Ferrer S 1 | Dihalogen-acetamino-benzylamines and process for preparing the same |
-
1978
- 1978-05-29 IT IT23931/78A patent/IT1094864B/it active
- 1978-08-10 DE DE19782835043 patent/DE2835043A1/de not_active Ceased
- 1978-08-21 ES ES472708A patent/ES472708A1/es not_active Expired
- 1978-10-16 US US05/952,589 patent/US4191780A/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
IT7823931A0 (it) | 1978-05-29 |
US4191780A (en) | 1980-03-04 |
DE2835043A1 (de) | 1979-12-06 |
IT1094864B (it) | 1985-08-10 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ES476220A1 (es) | Procedimiento de preparacion del alcohol (s)-a-ciano-3-feno-xibencilico | |
ES472708A1 (es) | Procedimiento para la preparacion de derivados de bromhexina | |
DE3062340D1 (en) | 1-n-alkylsisomicin derivatives, process for their preparation and their use as medicines | |
JPS53134060A (en) | Novel polysaccharide | |
ES465346A1 (es) | Procedimiento para preparar imidazoles 4,5-disustituidos. | |
JPS5273878A (en) | Synthesis of 6-carboxyacetyl-3,4-dihydrocarbostyril | |
JPS5422380A (en) | Preparation of substituted pipebrazine | |
JPS5430135A (en) | 4-hydroxy-4-methyl-cyclohexene-2-one-1 | |
JPS549273A (en) | 7-arginylamono-4-methylcoumarin | |
JPS51113882A (en) | Method for preparing 1-(alpha -alkoxyalkyl)-uracil derivatives | |
JPS5392774A (en) | 5,6,7,3',4',5'-hexahydrooxyflavone | |
JPS51136689A (en) | Process for preparing trithiane compounds | |
JPS51141855A (en) | Process for preparing exo-hydroxy-endo-tricyclo-(5,2,2,02,6)undecane | |
FR2407925B1 (es) | ||
JPS51136257A (en) | Copy of stored program | |
JPS5223086A (en) | Novel method of preparing 2,3- dioxopiperazine | |
JPS5423133A (en) | Prophylactic and remedy for coccidiosis | |
ES459924A1 (es) | Un procedimiento para la obtencion de 3-tienil-3-metil-4-piridilcetona. | |
JPS5257156A (en) | Process for preparing 5,6_trans-24-hydroxycholecalciferol | |
JPS5430182A (en) | Preparation of 3,4-dihydroxycarbostyril derivative | |
JPS53112872A (en) | Novel 5-fluoro-3-phenylindole | |
JPS53116491A (en) | Plug blade holder for molded plug | |
JPS53111051A (en) | 4-homoisotwistan-4-one | |
JPS52251A (en) | Process for preparation of endo-tricyclo (5,2,2,02,6)-undecane-8-one | |
JPS52118458A (en) | Novel methanoanthracene derivatives |