ES8301895A1 - 2-amino-3-(halobenzoyl)-methylphenylacetic acids, esters and salts thereof - Google Patents

2-amino-3-(halobenzoyl)-methylphenylacetic acids, esters and salts thereof

Info

Publication number
ES8301895A1
ES8301895A1 ES509622A ES509622A ES8301895A1 ES 8301895 A1 ES8301895 A1 ES 8301895A1 ES 509622 A ES509622 A ES 509622A ES 509622 A ES509622 A ES 509622A ES 8301895 A1 ES8301895 A1 ES 8301895A1
Authority
ES
Spain
Prior art keywords
halobenzoyl
esters
salts
amino
methylphenylacetic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES509622A
Other languages
Spanish (es)
Other versions
ES509622A0 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AH Robins Co Inc
Original Assignee
AH Robins Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by AH Robins Co Inc filed Critical AH Robins Co Inc
Publication of ES8301895A1 publication Critical patent/ES8301895A1/en
Publication of ES509622A0 publication Critical patent/ES509622A0/en
Granted legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/196—Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/222—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin with compounds having aromatic groups, e.g. dipivefrine, ibopamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
    • A61K31/24—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group having an amino or nitro group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C1/00—Preparation of hydrocarbons from one or more compounds, none of them being a hydrocarbon
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/40—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to carbon atoms of at least one six-membered aromatic ring and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/42—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to carbon atoms of at least one six-membered aromatic ring and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton with carboxyl groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by saturated carbon chains
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/30—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/30—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings
    • C07C57/32—Phenylacetic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/46—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings and other rings, e.g. cyclohexylphenylacetic acid

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Indole Compounds (AREA)

Abstract

Novel 2-amino-3-(halobenzoyl)- methylphenylacetic acids, esters and salts having the formula: < IMAGE > wherein R represents a hydrogen atom, a lower alkyl group or a pharmaceutically acceptable metal cation, Y represents a halogen atom and n is an integer from 1 to 3 are provided. The compounds exhibit outstanding anti-inflammatory and analgesic activity in warm blooded animals with minimal gastro-intestinal toxicity.
ES509622A 1981-02-17 1982-02-16 "PROCEDURE TO PREPARE NEW ACIDES 2-AMINO-3- (HALOBENZOIL) -METILFENILACETICOS, ITS ESTERS AND ITS METAL SALTS". Granted ES509622A0 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US23453181A 1981-02-17 1981-02-17

Publications (2)

Publication Number Publication Date
ES8301895A1 true ES8301895A1 (en) 1982-12-16
ES509622A0 ES509622A0 (en) 1982-12-16

Family

ID=22881752

Family Applications (1)

Application Number Title Priority Date Filing Date
ES509622A Granted ES509622A0 (en) 1981-02-17 1982-02-16 "PROCEDURE TO PREPARE NEW ACIDES 2-AMINO-3- (HALOBENZOIL) -METILFENILACETICOS, ITS ESTERS AND ITS METAL SALTS".

Country Status (32)

Country Link
JP (1) JPS57149256A (en)
KR (1) KR880002289B1 (en)
AT (1) AT387213B (en)
AU (1) AU7950382A (en)
BE (1) BE892156A (en)
CA (1) CA1173852A (en)
CH (1) CH651294A5 (en)
DE (1) DE3204854C2 (en)
DK (1) DK155936C (en)
EG (1) EG15798A (en)
ES (1) ES509622A0 (en)
FI (1) FI73970C (en)
FR (1) FR2499981B1 (en)
GB (1) GB2093027B (en)
GR (1) GR76516B (en)
HK (1) HK90384A (en)
HU (1) HU187644B (en)
IE (1) IE52289B1 (en)
IL (1) IL64724A0 (en)
IT (1) IT1157001B (en)
KE (1) KE3454A (en)
LU (1) LU83928A1 (en)
MY (1) MY8500908A (en)
NL (1) NL8200607A (en)
NO (1) NO160133C (en)
NZ (1) NZ199745A (en)
PL (1) PL139815B1 (en)
PT (1) PT74441B (en)
SE (1) SE453387B (en)
SG (1) SG68584G (en)
YU (1) YU44333B (en)
ZA (1) ZA82697B (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4683242A (en) * 1985-10-28 1987-07-28 A. H. Robins Company, Incorporated Transdermal treatment for pain and inflammation with 2-amino-3-aroylbenzeneacetic acids, salts and esters
US5475034A (en) * 1994-06-06 1995-12-12 Alcon Laboratories, Inc. Topically administrable compositions containing 3-benzoylphenylacetic acid derivatives for treatment of ophthalmic inflammatory disorders
US6034266A (en) * 1996-03-11 2000-03-07 Fundacao Oswaldo Cruz-Fiocruz Gem-difluoro derivative of phenylacetamide and phenylacetic acid and their pharmaceutical uses
BR9600975A (en) * 1996-03-11 1997-12-30 Fundacao Oswaldo Cruz Derivatives of gem-difluorphenylacetic acid and gem-difluorphenylacetamide process of their preparation and their pharmaceutical applications
AR030345A1 (en) * 2000-08-14 2003-08-20 Alcon Inc METHOD OF TREATMENT OF DISORDERS RELATED TO ANGIOGENESIS
AR030346A1 (en) * 2000-08-14 2003-08-20 Alcon Inc METHOD OF TREATMENT OF NEURODEGENERATIVE DISORDERS OF THE RETINA AND HEAD OF OPTICAL NERVE
AU2002247284A1 (en) 2001-04-02 2002-10-15 Alcon, Inc. Method of treating ocular inflammatory and angiogenesis-related disorders using an amide derivative of flubiprofen or ketorolac
TWI358290B (en) 2004-12-02 2012-02-21 Alcon Inc Topical nepafenac formulations

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1226344A (en) * 1967-07-31 1971-03-24
US3997368A (en) * 1975-06-24 1976-12-14 Bell Telephone Laboratories, Incorporated Elimination of stacking faults in silicon devices: a gettering process
CH577461A5 (en) * 1975-08-13 1976-07-15 Robins Co Inc A H
FR2366015A1 (en) * 1975-11-05 1978-04-28 Robins Co Inc A H Amino-benzoyl-phenylacetic acid derivs - antiinflammatory, hypocholesterolemic and blood platelet agglomeration inhibitory activity
IL61945A (en) * 1980-02-19 1984-09-30 Robins Co Inc A H 2-amino-3-(hydroxy(phenyl)methyl)phenylacetic acids,esters and amides and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
ATA43382A (en) 1988-05-15
FR2499981A1 (en) 1982-08-20
IT8267152A0 (en) 1982-02-10
DK155936B (en) 1989-06-05
NL8200607A (en) 1982-09-16
CH651294A5 (en) 1985-09-13
JPH0365338B2 (en) 1991-10-11
FI73970C (en) 1987-12-10
IL64724A0 (en) 1982-03-31
GB2093027A (en) 1982-08-25
SG68584G (en) 1985-03-15
CA1173852A (en) 1984-09-04
DK67382A (en) 1982-08-18
SE8200891L (en) 1982-08-18
IE820310L (en) 1982-08-17
YU44333B (en) 1990-06-30
PT74441A (en) 1982-03-01
NZ199745A (en) 1985-07-12
FR2499981B1 (en) 1986-05-23
IE52289B1 (en) 1987-09-02
GB2093027B (en) 1984-07-04
JPS57149256A (en) 1982-09-14
ES509622A0 (en) 1982-12-16
ZA82697B (en) 1983-01-26
DE3204854C2 (en) 1994-06-16
LU83928A1 (en) 1983-06-07
PL235095A1 (en) 1982-11-08
HK90384A (en) 1984-11-23
DK155936C (en) 1989-11-06
KR880002289B1 (en) 1988-10-22
DE3204854A1 (en) 1982-09-09
KE3454A (en) 1984-10-12
NO160133B (en) 1988-12-05
NO820468L (en) 1982-08-18
FI820392L (en) 1982-08-18
EG15798A (en) 1986-06-30
IT1157001B (en) 1987-02-11
AT387213B (en) 1988-12-27
MY8500908A (en) 1985-12-31
SE453387B (en) 1988-02-01
BE892156A (en) 1982-06-16
KR830008990A (en) 1983-12-16
PL139815B1 (en) 1987-02-28
GR76516B (en) 1984-08-10
NO160133C (en) 1989-03-15
YU32582A (en) 1985-06-30
HU187644B (en) 1986-02-28
FI73970B (en) 1987-08-31
PT74441B (en) 1983-08-24
AU7950382A (en) 1982-08-26

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19971001