ES8300859A1 - Un procedimiento para la produccion de urogastrona o una suburnidad de la misma. - Google Patents
Un procedimiento para la produccion de urogastrona o una suburnidad de la misma.Info
- Publication number
- ES8300859A1 ES8300859A1 ES504548A ES504548A ES8300859A1 ES 8300859 A1 ES8300859 A1 ES 8300859A1 ES 504548 A ES504548 A ES 504548A ES 504548 A ES504548 A ES 504548A ES 8300859 A1 ES8300859 A1 ES 8300859A1
- Authority
- ES
- Spain
- Prior art keywords
- urogastrone
- production
- expression
- transformed cells
- synthetic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 101800003838 Epidermal growth factor Proteins 0.000 title abstract 5
- VBEQCZHXXJYVRD-GACYYNSASA-N uroanthelone Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CS)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)C(C)C)[C@@H](C)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CCSC)NC(=O)[C@H](CS)NC(=O)[C@@H](NC(=O)CNC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CS)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CS)NC(=O)CNC(=O)[C@H]1N(CCC1)C(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(N)=O)C(C)C)[C@@H](C)CC)C1=CC=C(O)C=C1 VBEQCZHXXJYVRD-GACYYNSASA-N 0.000 title abstract 4
- 239000013612 plasmid Substances 0.000 title abstract 2
- 102000009024 Epidermal Growth Factor Human genes 0.000 title 1
- 102400001368 Epidermal growth factor Human genes 0.000 abstract 3
- 108700005078 Synthetic Genes Proteins 0.000 abstract 1
- 208000025865 Ulcer Diseases 0.000 abstract 1
- 239000002773 nucleotide Substances 0.000 abstract 1
- 125000003729 nucleotide group Chemical group 0.000 abstract 1
- 229920001184 polypeptide Polymers 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 231100000397 ulcer Toxicity 0.000 abstract 1
- 210000002700 urine Anatomy 0.000 abstract 1
- 230000029663 wound healing Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/485—Epidermal growth factor [EGF], i.e. urogastrone
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/70—Vectors or expression systems specially adapted for E. coli
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
- C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/822—Microorganisms using bacteria or actinomycetales
- Y10S435/848—Escherichia
- Y10S435/849—Escherichia coli
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S930/00—Peptide or protein sequence
- Y10S930/01—Peptide or protein sequence
- Y10S930/12—Growth hormone, growth factor other than t-cell or b-cell growth factor, and growth hormone releasing factor; related peptides
Landscapes
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Toxicology (AREA)
- Medicinal Chemistry (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
Abstract
PROCEDIMIENTO PARA LA OBTENCION DE UROGASTRONA O UNA SUBUNIDAD DE LA MISMA. CONSISTE EN ENSAMBLAR Y LIGAR VARIOS BLOQUES OLIGONUCLEOTIDICOS PARA OBTENER UN GEN SINTETICO, O UNA SUBUNIDAD DEL MISMO, QUE CODIFICA LA UROGASTRONA O SU SUBUNIDAD; INSERTAR EL PRODUCTO OBTENIDO EN UN SITIO DE INSERCION ADECUADO DE UN VECTOR PLASMIDICO; TRANSFORMAR UNA CELULA CON CUALQUIERA DE LOS PRODUCTOS ANTERIORES, RECULTIVAR LA CELULA OBTENIDA Y RECUPERAR LA PROTEINA. >ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS PARA EL TRATAMIENTO DE LAS ULCERAS Y LA CURACION DE HERIDAS.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB8025440 | 1980-08-05 |
Publications (2)
Publication Number | Publication Date |
---|---|
ES8300859A1 true ES8300859A1 (es) | 1982-11-01 |
ES504548A0 ES504548A0 (es) | 1982-11-01 |
Family
ID=10515236
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES504548A Granted ES504548A0 (es) | 1980-08-05 | 1981-08-04 | Un procedimiento para la produccion de urogastrona o una suburnidad de la misma. |
Country Status (9)
Country | Link |
---|---|
US (1) | US4719180A (es) |
EP (1) | EP0046039B2 (es) |
JP (1) | JPS57122096A (es) |
AU (1) | AU547077B2 (es) |
CA (1) | CA1197797A (es) |
DE (1) | DE3175829D1 (es) |
DK (1) | DK339781A (es) |
ES (1) | ES504548A0 (es) |
IE (1) | IE53166B1 (es) |
Families Citing this family (49)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4532207A (en) * | 1982-03-19 | 1985-07-30 | G. D. Searle & Co. | Process for the preparation of polypeptides utilizing a charged amino acid polymer and exopeptidase |
US4880911A (en) * | 1982-03-19 | 1989-11-14 | G. D. Searle & Co. | Fused polypeptides and methods for their detection |
US6936694B1 (en) * | 1982-05-06 | 2005-08-30 | Intermune, Inc. | Manufacture and expression of large structural genes |
WO1983004030A1 (en) * | 1982-05-06 | 1983-11-24 | Applied Molecular Genetics, Inc. | The manufacture and expression of genes for urogastrone and polypeptide analogs thereof |
US4652639A (en) * | 1982-05-06 | 1987-03-24 | Amgen | Manufacture and expression of structural genes |
US5151511A (en) * | 1982-09-16 | 1992-09-29 | Amgen Inc. | DNA encoding avian growth hormones |
US5096825A (en) * | 1983-01-12 | 1992-03-17 | Chiron Corporation | Gene for human epidermal growth factor and synthesis and expression thereof |
US4764593A (en) * | 1983-04-25 | 1988-08-16 | Amgen Inc. | Manufacture and expression of genes for urogastrone and polypeptide analogs thereof |
EP0129268B1 (en) * | 1983-05-19 | 1989-10-04 | Unilever N.V. | Improvements in the expression of newly introduced genes in yeast cells |
IL71991A (en) | 1983-06-06 | 1994-05-30 | Genentech Inc | Preparation of human FGI and FGE in their processed form through recombinant AND tranology in prokaryotes |
JPS6023325A (ja) * | 1983-06-15 | 1985-02-05 | Kazuoki Tsuchiya | 皮膚病塗布剤 |
EP0148922A4 (en) * | 1983-07-05 | 1987-06-15 | Chiron Corp | SYNTHESIS USING HYBRID EPIDERMAL GROWTH FACTOR DNA. |
US4783412A (en) * | 1983-07-05 | 1988-11-08 | Chiron Corporation | Hybrid DNA synthesis of epidermal growth factor |
JPS6028994A (ja) * | 1983-07-08 | 1985-02-14 | Wakunaga Seiyaku Kk | 〔21―ロイシン〕ヒトウロガストロン |
US4689406A (en) * | 1983-08-10 | 1987-08-25 | Amgen | Enhancement of microbial expression of polypeptides |
US4870008A (en) * | 1983-08-12 | 1989-09-26 | Chiron Corporation | Secretory expression in eukaryotes |
WO1985002198A1 (en) * | 1983-11-01 | 1985-05-23 | Amgen | Microbial expression of type i transforming growth factor, polypeptide analogs thereof and hybrid egf/tgf polypeptides |
EP0162898A4 (en) * | 1983-11-14 | 1987-07-23 | Chiron Corp | INTERLEUKIN-2 GENERATION USING CLONED GENES FOR INTERLEUKIN-2 AND YEAR ALPHA FACTOR. |
BE898666A (fr) * | 1984-01-12 | 1984-05-02 | Wallone Region | Procede de preparation de clones bacteriens portant une information genetique optimalisee pour la production du facteur de declenchement de l'hormone de croissance humaine dans escherichia coli |
JPS619282A (ja) * | 1984-06-22 | 1986-01-16 | Hitachi Ltd | 遺伝子組換え菌の培養方法 |
JP2554459B2 (ja) * | 1984-07-02 | 1996-11-13 | アース製薬 株式会社 | β−ウロガストロン遺伝子、対応プラスミド組換体及び対応形質転換体 |
JP2524693B2 (ja) * | 1984-07-30 | 1996-08-14 | 湧永製薬株式会社 | 蛋白質の製造法 |
DE3429430A1 (de) * | 1984-08-10 | 1986-02-20 | Hoechst Ag, 6230 Frankfurt | Gentechnologisches verfahren zur herstellung von hirudin und mittel zur durchfuehrung dieses verfahrens |
CA1263619A (en) * | 1984-10-09 | 1989-12-05 | Ryuji Marumoto | Dna, production and use thereof |
JPH0611709B2 (ja) * | 1984-10-19 | 1994-02-16 | チロン コーポレイション | 角膜基質創傷の治療のための組成物 |
JPS62501071A (ja) * | 1984-10-30 | 1987-04-30 | オンコゲン | 成長因子活性を有する新規なポリペプチド及び該ポリペプチドをコ−ドする核酸配列 |
GB8507666D0 (en) * | 1985-03-25 | 1985-05-01 | Wellcome Found | Epidermal growth factor production |
GB8515686D0 (en) * | 1985-06-20 | 1985-07-24 | Fujisawa Pharmaceutical Co | Production of-human atrial natriuretic polypeptide |
EP0440311A1 (en) * | 1985-06-20 | 1991-08-07 | Fujisawa Pharmaceutical Co., Ltd. | A process for the production of alpha-human atrial natriuretic polypeptide |
US4743679A (en) * | 1986-02-24 | 1988-05-10 | Creative Biomolecules, Inc. | Process for producing human epidermal growth factor and analogs thereof |
IN165717B (es) * | 1986-08-07 | 1989-12-23 | Battelle Memorial Institute | |
US5306289A (en) * | 1987-08-26 | 1994-04-26 | United States Surgical Corporation | Braided suture of improved characteristics |
US5366081A (en) | 1987-08-26 | 1994-11-22 | United States Surgical Corporation | Packaged synthetic absorbable surgical elements |
US5222978A (en) | 1987-08-26 | 1993-06-29 | United States Surgical Corporation | Packaged synthetic absorbable surgical elements |
US5226912A (en) | 1987-08-26 | 1993-07-13 | United States Surgical Corporation | Combined surgical needle-braided suture device |
US5472702A (en) * | 1987-08-26 | 1995-12-05 | United States Surgical Corporation | Sterilization of growth factors |
US5102789A (en) * | 1989-03-15 | 1992-04-07 | The Salk Institute Biotechnology/Industrial Associates, Inc. | Production of epideramal growth factor in pichia pastoris yeast cells |
US5158935A (en) * | 1989-05-12 | 1992-10-27 | Chiron Corporation | Human epidermal growth factor having substitution at position 11 |
US5359831A (en) | 1989-08-01 | 1994-11-01 | United States Surgical Corporation | Molded suture retainer |
DK0541726T3 (da) * | 1990-08-02 | 2000-08-21 | Indu Parikh | Vækstfaktorsammensætninger, fremstilling og anvendelse |
US5434135A (en) * | 1990-08-02 | 1995-07-18 | Indu Parikh | Growth factor compositions, preparation and use |
CA2059245C (en) * | 1991-02-08 | 2004-07-06 | Michael P. Chesterfield | Method and apparatus for calendering and coating/filling sutures |
AU2489992A (en) * | 1991-08-16 | 1993-03-16 | Chiron Corporation | Muteins of epidermal growth factor exhibiting enhanced binding at low ph |
DE69427515T2 (de) * | 1993-04-26 | 2001-10-04 | Dae Woong Pharmaceutical Co. Ltd., Seongnam | Neuartiger genvektor codierend fur den epidermis wachstumsfaktor und verfahren zu seiner herstellung |
US5904716A (en) * | 1995-04-26 | 1999-05-18 | Gendler; El | Method for reconstituting cartilage tissue using demineralized bone and product thereof |
US5888731A (en) * | 1995-08-30 | 1999-03-30 | Visible Genetics Inc. | Method for identification of mutations using ligation of multiple oligonucleotide probes |
EA001077B1 (ru) * | 1996-04-24 | 2000-10-30 | Апплайд Резеч Системз Арс Холдинг Н.В. | Компонент в, используемый в качестве рубцующего агента, содержащая его фармацевтическая композиция и способ лечения |
DE602005003374T2 (de) * | 2005-10-17 | 2008-09-11 | Pls-Design Gmbh | Verfahren zur Bestimmung einer unbekannten PNS Seqenz und seine Verwendungen |
US20090192554A1 (en) | 2008-01-29 | 2009-07-30 | Confluent Surgical, Inc. | Bioabsorbable block copolymer |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA1201668A (en) * | 1977-11-08 | 1986-03-11 | Genentech, Inc. | Synthetic dna and method therefor |
US4322499A (en) * | 1978-12-22 | 1982-03-30 | The Regents Of The University Of California | Adrenocorticotropin-lipotropin precursor gene |
US4293652A (en) * | 1979-05-25 | 1981-10-06 | Cetus Corporation | Method for synthesizing DNA sequentially |
US4342832A (en) * | 1979-07-05 | 1982-08-03 | Genentech, Inc. | Method of constructing a replicable cloning vehicle having quasi-synthetic genes |
-
1981
- 1981-07-29 IE IE1715/81A patent/IE53166B1/en not_active IP Right Cessation
- 1981-07-29 DK DK339781A patent/DK339781A/da not_active Application Discontinuation
- 1981-07-31 DE DE8181303517T patent/DE3175829D1/de not_active Expired
- 1981-07-31 EP EP81303517A patent/EP0046039B2/en not_active Expired
- 1981-08-03 AU AU73645/81A patent/AU547077B2/en not_active Ceased
- 1981-08-04 ES ES504548A patent/ES504548A0/es active Granted
- 1981-08-04 JP JP56121498A patent/JPS57122096A/ja active Pending
- 1981-08-05 CA CA000383208A patent/CA1197797A/en not_active Expired
-
1984
- 1984-09-13 US US06/649,885 patent/US4719180A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
IE811715L (en) | 1982-02-05 |
EP0046039A1 (en) | 1982-02-17 |
AU547077B2 (en) | 1985-10-03 |
CA1197797A (en) | 1985-12-10 |
EP0046039B2 (en) | 1990-01-24 |
IE53166B1 (en) | 1988-08-03 |
JPS57122096A (en) | 1982-07-29 |
ES504548A0 (es) | 1982-11-01 |
US4719180A (en) | 1988-01-12 |
AU7364581A (en) | 1982-02-11 |
EP0046039B1 (en) | 1987-01-14 |
DK339781A (da) | 1982-02-06 |
DE3175829D1 (en) | 1987-02-19 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD1A | Patent lapsed |
Effective date: 19960603 |