ES8300859A1 - Un procedimiento para la produccion de urogastrona o una suburnidad de la misma. - Google Patents

Un procedimiento para la produccion de urogastrona o una suburnidad de la misma.

Info

Publication number
ES8300859A1
ES8300859A1 ES504548A ES504548A ES8300859A1 ES 8300859 A1 ES8300859 A1 ES 8300859A1 ES 504548 A ES504548 A ES 504548A ES 504548 A ES504548 A ES 504548A ES 8300859 A1 ES8300859 A1 ES 8300859A1
Authority
ES
Spain
Prior art keywords
urogastrone
production
expression
transformed cells
synthetic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES504548A
Other languages
English (en)
Other versions
ES504548A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GD Searle LLC
Original Assignee
GD Searle LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10515236&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES8300859(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by GD Searle LLC filed Critical GD Searle LLC
Publication of ES8300859A1 publication Critical patent/ES8300859A1/es
Publication of ES504548A0 publication Critical patent/ES504548A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/485—Epidermal growth factor [EGF], i.e. urogastrone
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
    • C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/848—Escherichia
    • Y10S435/849—Escherichia coli
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/12—Growth hormone, growth factor other than t-cell or b-cell growth factor, and growth hormone releasing factor; related peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Medicinal Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE UROGASTRONA O UNA SUBUNIDAD DE LA MISMA. CONSISTE EN ENSAMBLAR Y LIGAR VARIOS BLOQUES OLIGONUCLEOTIDICOS PARA OBTENER UN GEN SINTETICO, O UNA SUBUNIDAD DEL MISMO, QUE CODIFICA LA UROGASTRONA O SU SUBUNIDAD; INSERTAR EL PRODUCTO OBTENIDO EN UN SITIO DE INSERCION ADECUADO DE UN VECTOR PLASMIDICO; TRANSFORMAR UNA CELULA CON CUALQUIERA DE LOS PRODUCTOS ANTERIORES, RECULTIVAR LA CELULA OBTENIDA Y RECUPERAR LA PROTEINA. >ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS PARA EL TRATAMIENTO DE LAS ULCERAS Y LA CURACION DE HERIDAS.
ES504548A 1980-08-05 1981-08-04 Un procedimiento para la produccion de urogastrona o una suburnidad de la misma. Granted ES504548A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB8025440 1980-08-05

Publications (2)

Publication Number Publication Date
ES8300859A1 true ES8300859A1 (es) 1982-11-01
ES504548A0 ES504548A0 (es) 1982-11-01

Family

ID=10515236

Family Applications (1)

Application Number Title Priority Date Filing Date
ES504548A Granted ES504548A0 (es) 1980-08-05 1981-08-04 Un procedimiento para la produccion de urogastrona o una suburnidad de la misma.

Country Status (9)

Country Link
US (1) US4719180A (es)
EP (1) EP0046039B2 (es)
JP (1) JPS57122096A (es)
AU (1) AU547077B2 (es)
CA (1) CA1197797A (es)
DE (1) DE3175829D1 (es)
DK (1) DK339781A (es)
ES (1) ES504548A0 (es)
IE (1) IE53166B1 (es)

Families Citing this family (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4532207A (en) * 1982-03-19 1985-07-30 G. D. Searle & Co. Process for the preparation of polypeptides utilizing a charged amino acid polymer and exopeptidase
US4880911A (en) * 1982-03-19 1989-11-14 G. D. Searle & Co. Fused polypeptides and methods for their detection
US6936694B1 (en) * 1982-05-06 2005-08-30 Intermune, Inc. Manufacture and expression of large structural genes
WO1983004030A1 (en) * 1982-05-06 1983-11-24 Applied Molecular Genetics, Inc. The manufacture and expression of genes for urogastrone and polypeptide analogs thereof
US4652639A (en) * 1982-05-06 1987-03-24 Amgen Manufacture and expression of structural genes
US5151511A (en) * 1982-09-16 1992-09-29 Amgen Inc. DNA encoding avian growth hormones
US5096825A (en) * 1983-01-12 1992-03-17 Chiron Corporation Gene for human epidermal growth factor and synthesis and expression thereof
US4764593A (en) * 1983-04-25 1988-08-16 Amgen Inc. Manufacture and expression of genes for urogastrone and polypeptide analogs thereof
EP0129268B1 (en) * 1983-05-19 1989-10-04 Unilever N.V. Improvements in the expression of newly introduced genes in yeast cells
IL71991A (en) 1983-06-06 1994-05-30 Genentech Inc Preparation of human FGI and FGE in their processed form through recombinant AND tranology in prokaryotes
JPS6023325A (ja) * 1983-06-15 1985-02-05 Kazuoki Tsuchiya 皮膚病塗布剤
EP0148922A4 (en) * 1983-07-05 1987-06-15 Chiron Corp SYNTHESIS USING HYBRID EPIDERMAL GROWTH FACTOR DNA.
US4783412A (en) * 1983-07-05 1988-11-08 Chiron Corporation Hybrid DNA synthesis of epidermal growth factor
JPS6028994A (ja) * 1983-07-08 1985-02-14 Wakunaga Seiyaku Kk 〔２１―ロイシン〕ヒトウロガストロン
US4689406A (en) * 1983-08-10 1987-08-25 Amgen Enhancement of microbial expression of polypeptides
US4870008A (en) * 1983-08-12 1989-09-26 Chiron Corporation Secretory expression in eukaryotes
WO1985002198A1 (en) * 1983-11-01 1985-05-23 Amgen Microbial expression of type i transforming growth factor, polypeptide analogs thereof and hybrid egf/tgf polypeptides
EP0162898A4 (en) * 1983-11-14 1987-07-23 Chiron Corp INTERLEUKIN-2 GENERATION USING CLONED GENES FOR INTERLEUKIN-2 AND YEAR ALPHA FACTOR.
BE898666A (fr) * 1984-01-12 1984-05-02 Wallone Region Procede de preparation de clones bacteriens portant une information genetique optimalisee pour la production du facteur de declenchement de l'hormone de croissance humaine dans escherichia coli
JPS619282A (ja) * 1984-06-22 1986-01-16 Hitachi Ltd 遺伝子組換え菌の培養方法
JP2554459B2 (ja) * 1984-07-02 1996-11-13 アース製薬 株式会社 β−ウロガストロン遺伝子、対応プラスミド組換体及び対応形質転換体
JP2524693B2 (ja) * 1984-07-30 1996-08-14 湧永製薬株式会社 蛋白質の製造法
DE3429430A1 (de) * 1984-08-10 1986-02-20 Hoechst Ag, 6230 Frankfurt Gentechnologisches verfahren zur herstellung von hirudin und mittel zur durchfuehrung dieses verfahrens
CA1263619A (en) * 1984-10-09 1989-12-05 Ryuji Marumoto Dna, production and use thereof
JPH0611709B2 (ja) * 1984-10-19 1994-02-16 チロン コーポレイション 角膜基質創傷の治療のための組成物
JPS62501071A (ja) * 1984-10-30 1987-04-30 オンコゲン 成長因子活性を有する新規なポリペプチド及び該ポリペプチドをコ−ドする核酸配列
GB8507666D0 (en) * 1985-03-25 1985-05-01 Wellcome Found Epidermal growth factor production
GB8515686D0 (en) * 1985-06-20 1985-07-24 Fujisawa Pharmaceutical Co Production of-human atrial natriuretic polypeptide
EP0440311A1 (en) * 1985-06-20 1991-08-07 Fujisawa Pharmaceutical Co., Ltd. A process for the production of alpha-human atrial natriuretic polypeptide
US4743679A (en) * 1986-02-24 1988-05-10 Creative Biomolecules, Inc. Process for producing human epidermal growth factor and analogs thereof
IN165717B (es) * 1986-08-07 1989-12-23 Battelle Memorial Institute
US5306289A (en) * 1987-08-26 1994-04-26 United States Surgical Corporation Braided suture of improved characteristics
US5366081A (en) 1987-08-26 1994-11-22 United States Surgical Corporation Packaged synthetic absorbable surgical elements
US5222978A (en) 1987-08-26 1993-06-29 United States Surgical Corporation Packaged synthetic absorbable surgical elements
US5226912A (en) 1987-08-26 1993-07-13 United States Surgical Corporation Combined surgical needle-braided suture device
US5472702A (en) * 1987-08-26 1995-12-05 United States Surgical Corporation Sterilization of growth factors
US5102789A (en) * 1989-03-15 1992-04-07 The Salk Institute Biotechnology/Industrial Associates, Inc. Production of epideramal growth factor in pichia pastoris yeast cells
US5158935A (en) * 1989-05-12 1992-10-27 Chiron Corporation Human epidermal growth factor having substitution at position 11
US5359831A (en) 1989-08-01 1994-11-01 United States Surgical Corporation Molded suture retainer
DK0541726T3 (da) * 1990-08-02 2000-08-21 Indu Parikh Vækstfaktorsammensætninger, fremstilling og anvendelse
US5434135A (en) * 1990-08-02 1995-07-18 Indu Parikh Growth factor compositions, preparation and use
CA2059245C (en) * 1991-02-08 2004-07-06 Michael P. Chesterfield Method and apparatus for calendering and coating/filling sutures
AU2489992A (en) * 1991-08-16 1993-03-16 Chiron Corporation Muteins of epidermal growth factor exhibiting enhanced binding at low ph
DE69427515T2 (de) * 1993-04-26 2001-10-04 Dae Woong Pharmaceutical Co. Ltd., Seongnam Neuartiger genvektor codierend fur den epidermis wachstumsfaktor und verfahren zu seiner herstellung
US5904716A (en) * 1995-04-26 1999-05-18 Gendler; El Method for reconstituting cartilage tissue using demineralized bone and product thereof
US5888731A (en) * 1995-08-30 1999-03-30 Visible Genetics Inc. Method for identification of mutations using ligation of multiple oligonucleotide probes
EA001077B1 (ru) * 1996-04-24 2000-10-30 Апплайд Резеч Системз Арс Холдинг Н.В. Компонент в, используемый в качестве рубцующего агента, содержащая его фармацевтическая композиция и способ лечения
DE602005003374T2 (de) * 2005-10-17 2008-09-11 Pls-Design Gmbh Verfahren zur Bestimmung einer unbekannten PNS Seqenz und seine Verwendungen
US20090192554A1 (en) 2008-01-29 2009-07-30 Confluent Surgical, Inc. Bioabsorbable block copolymer

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1201668A (en) * 1977-11-08 1986-03-11 Genentech, Inc. Synthetic dna and method therefor
US4322499A (en) * 1978-12-22 1982-03-30 The Regents Of The University Of California Adrenocorticotropin-lipotropin precursor gene
US4293652A (en) * 1979-05-25 1981-10-06 Cetus Corporation Method for synthesizing DNA sequentially
US4342832A (en) * 1979-07-05 1982-08-03 Genentech, Inc. Method of constructing a replicable cloning vehicle having quasi-synthetic genes

Also Published As

Publication number Publication date
IE811715L (en) 1982-02-05
EP0046039A1 (en) 1982-02-17
AU547077B2 (en) 1985-10-03
CA1197797A (en) 1985-12-10
EP0046039B2 (en) 1990-01-24
IE53166B1 (en) 1988-08-03
JPS57122096A (en) 1982-07-29
ES504548A0 (es) 1982-11-01
US4719180A (en) 1988-01-12
AU7364581A (en) 1982-02-11
EP0046039B1 (en) 1987-01-14
DK339781A (da) 1982-02-06
DE3175829D1 (en) 1987-02-19

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19960603