ES8206429A1 - Procedimiento para preparar 5z,8z,11z,14z,17z,eicosapentae- noatos de alquilfenilo. - Google Patents
Procedimiento para preparar 5z,8z,11z,14z,17z,eicosapentae- noatos de alquilfenilo.Info
- Publication number
- ES8206429A1 ES8206429A1 ES507122A ES507122A ES8206429A1 ES 8206429 A1 ES8206429 A1 ES 8206429A1 ES 507122 A ES507122 A ES 507122A ES 507122 A ES507122 A ES 507122A ES 8206429 A1 ES8206429 A1 ES 8206429A1
- Authority
- ES
- Spain
- Prior art keywords
- eicosapentaenoates
- alkylphenyl
- preparation
- disclosed
- methods
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/09—Preparation of carboxylic acids or their salts, halides or anhydrides from carboxylic acid esters or lactones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
PROCEDIMIENTO PARA LA OBTENCION DE 5Z,8Z,11Z,14Z-EICOSAPENTAENOATOS DE ALQUIL-FENILO, DE FORMULA (I), EN LA QUE R1 ES HIDROGENO, 2-ALQUILO C1-2 O 3-METILO, R2 ES HIDROGENO O ALQUILO C1-2 Y X ES FENILO SUSTITUIDO POR 1 A 3 ALQUILOS C1-4. CONSISTE EN LA REACCION DEL ESTER DE FORMULA (II), EN LA QUE X ES EL MISMO QUE EN LA FORMULA (I), CON N-LITIO-N-(1-METILETIL)CICLOHEXAMINA, EN TETRA-HIDROFURANO A - 78 C., BAJO ATMOSFERA DE NITROGENO, SEGUIDA DE LA REACCION IN SITU CON UN HALURO DE ALQUILO DE FORMULA R1HAL, EN LA QUE R1, ES EL MISMO QUE EN LA FORMULA (I) Y HAL ES HALOGENO. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS POR SU ACTIVIDAD COMO INHIBIDORES DE LA AGREGACION DE PLAQUETAS Y COMO AGENTES ANTISECRETORIOS.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US06/088,502 US4264517A (en) | 1978-12-11 | 1979-10-26 | Alkylphenyl 5Z,8Z,11Z,14Z,17Z-eicosapentaenoates |
Publications (2)
Publication Number | Publication Date |
---|---|
ES507122A0 ES507122A0 (es) | 1982-08-16 |
ES8206429A1 true ES8206429A1 (es) | 1982-08-16 |
Family
ID=22211743
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES496248A Expired ES8202781A1 (es) | 1979-10-26 | 1980-10-24 | Procedimiento para preparar 5z, 8z, 11z, 14z, 17z-eicosapen-taenoatos de alquifenilo |
ES507123A Granted ES507123A0 (es) | 1979-10-26 | 1981-11-13 | Procedimiento para preparar 5z,8z,11z,14z,17z-eicosapentae- noatos de alquilfenilo. |
ES507122A Expired ES8206429A1 (es) | 1979-10-26 | 1981-11-13 | Procedimiento para preparar 5z,8z,11z,14z,17z,eicosapentae- noatos de alquilfenilo. |
Family Applications Before (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES496248A Expired ES8202781A1 (es) | 1979-10-26 | 1980-10-24 | Procedimiento para preparar 5z, 8z, 11z, 14z, 17z-eicosapen-taenoatos de alquifenilo |
ES507123A Granted ES507123A0 (es) | 1979-10-26 | 1981-11-13 | Procedimiento para preparar 5z,8z,11z,14z,17z-eicosapentae- noatos de alquilfenilo. |
Country Status (11)
Country | Link |
---|---|
US (1) | US4264517A (es) |
JP (1) | JPS5686134A (es) |
BE (1) | BE885890A (es) |
CA (1) | CA1140576A (es) |
DE (1) | DE3039960A1 (es) |
DK (1) | DK452380A (es) |
ES (3) | ES8202781A1 (es) |
FR (1) | FR2468577A1 (es) |
GB (1) | GB2061277B (es) |
IT (1) | IT1133047B (es) |
NL (1) | NL8005876A (es) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4576758A (en) * | 1984-06-01 | 1986-03-18 | The Upjohn Company | Anti-inflammatory lipoxin B analogs |
CN102050720B (zh) | 2005-05-04 | 2013-03-13 | 普罗诺瓦生物医药挪威公司 | 新的dha衍生物及其作为药物的用途 |
GB0605900D0 (en) * | 2006-03-23 | 2006-05-03 | Lipigen As | Modulators of nuclear receptors |
EP2129646A2 (en) * | 2006-11-01 | 2009-12-09 | Pronova Biopharma Norge AS | Omega-3 lipid compounds |
KR101438177B1 (ko) * | 2006-11-01 | 2014-09-05 | 프로노바 바이오파마 너지 에이에스 | 페록시솜 증식자-활성화 수용체의 활성자 또는 조절자인 알파-치환된 오메가-3 지질 |
BRPI0717972A2 (pt) * | 2006-11-01 | 2013-11-12 | Pronova Biopharma Norge As | Lipídeos de ômega-3 alfa-substituídos que são ativadores ou moduladores do receptor ativado por proliferadores de peroxissoma (ppar) |
JP2010508262A (ja) * | 2006-11-01 | 2010-03-18 | プロノヴァ バイオファーマ ノルゲ アーエス | 組成物 |
KR20100100818A (ko) * | 2007-10-31 | 2010-09-15 | 프로노바 바이오파마 노르지 에이에스 | 새로운 dha 유도체 및 약물로서 그들의 사용 |
WO2009070748A1 (en) * | 2007-11-27 | 2009-06-04 | Umber Systems | System for collecting and analyzing data on application-level activity on a mobile data network |
MX2011000273A (es) | 2008-07-08 | 2011-05-23 | Catabasis Pharmaceuticals Inc | Salicilatos acetilados con acidos grasos y sus usos. |
US9085527B2 (en) | 2008-07-08 | 2015-07-21 | Catabasis Pharmaceuticals, Inc. | Fatty acid acylated salicylates and their uses |
USRE46608E1 (en) | 2009-09-01 | 2017-11-14 | Catabasis Pharmaceuticals, Inc. | Fatty acid niacin conjugates and their uses |
BR112012004677A2 (pt) | 2009-09-01 | 2020-11-03 | Catabasis Pharmaceuticals, Inc. | conjugados de ácido graxo niacina e seus usos |
CN102822141A (zh) * | 2010-01-20 | 2012-12-12 | 普罗诺瓦生物医药挪威公司 | 水杨酸脂肪酸衍生物 |
CN114853627B (zh) * | 2022-04-26 | 2023-06-20 | 自然资源部第三海洋研究所 | 一种取代苯甲酸二十二碳六烯酰胺乙基酯衍生物及其制备方法与应用 |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4181670A (en) * | 1978-12-11 | 1980-01-01 | G. D. Searle & Co. | Phenyl 5Z,8Z,11Z,14Z-eicosatetraenoate and congeners |
-
1979
- 1979-10-26 US US06/088,502 patent/US4264517A/en not_active Expired - Lifetime
-
1980
- 1980-10-23 DE DE19803039960 patent/DE3039960A1/de not_active Withdrawn
- 1980-10-24 GB GB8034380A patent/GB2061277B/en not_active Expired
- 1980-10-24 FR FR8022869A patent/FR2468577A1/fr not_active Withdrawn
- 1980-10-24 NL NL8005876A patent/NL8005876A/nl not_active Application Discontinuation
- 1980-10-24 ES ES496248A patent/ES8202781A1/es not_active Expired
- 1980-10-24 DK DK452380A patent/DK452380A/da not_active Application Discontinuation
- 1980-10-27 CA CA000363359A patent/CA1140576A/en not_active Expired
- 1980-10-27 JP JP15057880A patent/JPS5686134A/ja active Pending
- 1980-10-27 IT IT50013/80A patent/IT1133047B/it active
- 1980-10-27 BE BE0/202604A patent/BE885890A/fr unknown
-
1981
- 1981-11-13 ES ES507123A patent/ES507123A0/es active Granted
- 1981-11-13 ES ES507122A patent/ES8206429A1/es not_active Expired
Also Published As
Publication number | Publication date |
---|---|
JPS5686134A (en) | 1981-07-13 |
ES507122A0 (es) | 1982-08-16 |
IT8050013A0 (it) | 1980-10-27 |
FR2468577A1 (fr) | 1981-05-08 |
CA1140576A (en) | 1983-02-01 |
ES496248A0 (es) | 1982-02-16 |
NL8005876A (nl) | 1981-04-28 |
DK452380A (da) | 1981-04-27 |
GB2061277A (en) | 1981-05-13 |
ES8206430A1 (es) | 1982-08-16 |
GB2061277B (en) | 1983-11-16 |
ES507123A0 (es) | 1982-08-16 |
BE885890A (fr) | 1981-04-27 |
US4264517A (en) | 1981-04-28 |
ES8202781A1 (es) | 1982-02-16 |
DE3039960A1 (de) | 1981-05-07 |
IT1133047B (it) | 1986-07-09 |
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