ES8201986A1 - Un procedimiento para la preparacion de derivados de 1,2,4- triazolidin-3,5-diona - Google Patents

Un procedimiento para la preparacion de derivados de 1,2,4- triazolidin-3,5-diona

Info

Publication number
ES8201986A1
ES8201986A1 ES499471A ES499471A ES8201986A1 ES 8201986 A1 ES8201986 A1 ES 8201986A1 ES 499471 A ES499471 A ES 499471A ES 499471 A ES499471 A ES 499471A ES 8201986 A1 ES8201986 A1 ES 8201986A1
Authority
ES
Spain
Prior art keywords
alkyl
preparation
phenyl
analogons
prostaglandin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES499471A
Other languages
English (en)
Other versions
ES499471A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beecham Group PLC
Original Assignee
Beecham Group PLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beecham Group PLC filed Critical Beecham Group PLC
Publication of ES8201986A1 publication Critical patent/ES8201986A1/es
Publication of ES499471A0 publication Critical patent/ES499471A0/es
Granted legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D249/12—Oxygen or sulfur atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

PROCEDIMIENTO DE PREPARACION DE DERIVADOS DE 1,2,4-TRIAZOLIDIN-3,5-DIONA, DE FORMULA (I), EN QUE Y ES ETILO, ETENILO O ETINILO; R1 Y R5 SON ALQUILO; R2 HIDROGENO; R3 HIDROXILO, Y R4 HIDROGENO, ALQUILO, CICLOAQLUILO U OTROS. SE HACE REACCIONAR CON UN REACTIVO NUCLEOFILO DEL GRUPO CARBONILO TAL COMO UN COMPUESTO ORGANOMETALICO REACTIVO DE GRIGNARD, UN COMPUESTO DE FORMULA (II), EN QUE R22 Y R13 CON IGUALES A R2 Y R3, O FORMAN ENTRE SI UN GRUPO OXO; R16 ES HIDROXI; R7 ES HIDROGENO O FORMA CON R16 UN GRUPO DE OXO; EN PRESENCIA DE BOROHIDUROS O EN UN DISOLVENTE TAL COMO DIGLIMA. POSTERIORMENTE, CASO DE ESTAR PROTEGIDO EL GRUPO R16, SE DESPROTEGE POR REACCIONES DE DESALQUILACION O DESACILACION.
ES499471A 1979-07-12 1981-02-16 Un procedimiento para la preparacion de derivados de 1,2,4- triazolidin-3,5-diona Granted ES499471A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB7924235 1979-07-12

Publications (2)

Publication Number Publication Date
ES8201986A1 true ES8201986A1 (es) 1982-01-16
ES499471A0 ES499471A0 (es) 1982-01-16

Family

ID=10506447

Family Applications (2)

Application Number Title Priority Date Filing Date
ES493339A Granted ES493339A0 (es) 1979-07-12 1980-07-11 Un procedimiento para la preparacion de derivados de 1,2,4- triazolidin-3,5- diona.
ES499471A Granted ES499471A0 (es) 1979-07-12 1981-02-16 Un procedimiento para la preparacion de derivados de 1,2,4- triazolidin-3,5-diona

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES493339A Granted ES493339A0 (es) 1979-07-12 1980-07-11 Un procedimiento para la preparacion de derivados de 1,2,4- triazolidin-3,5- diona.

Country Status (7)

Country Link
EP (1) EP0024105A1 (es)
JP (1) JPS5615275A (es)
AU (1) AU6031280A (es)
DK (1) DK302980A (es)
ES (2) ES493339A0 (es)
IL (1) IL60544A0 (es)
ZA (1) ZA804188B (es)

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4294972A (en) * 1978-06-15 1981-10-13 Beecham Group Limited 1,2-Disubstituted oxo triazolidine

Also Published As

Publication number Publication date
ES8106146A1 (es) 1981-07-16
JPS5615275A (en) 1981-02-14
ES493339A0 (es) 1981-07-16
IL60544A0 (en) 1980-09-16
ES499471A0 (es) 1982-01-16
EP0024105A1 (en) 1981-02-25
ZA804188B (en) 1981-07-29
AU6031280A (en) 1981-01-15
DK302980A (da) 1981-01-13

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