ES8107206A1 - Procedimiento para obtener derivados de tiazol - Google Patents

Procedimiento para obtener derivados de tiazol

Info

Publication number
ES8107206A1
ES8107206A1 ES495971A ES495971A ES8107206A1 ES 8107206 A1 ES8107206 A1 ES 8107206A1 ES 495971 A ES495971 A ES 495971A ES 495971 A ES495971 A ES 495971A ES 8107206 A1 ES8107206 A1 ES 8107206A1
Authority
ES
Spain
Prior art keywords
carbon atoms
benzyloxyphenyl
amino
thiazoles
production
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES495971A
Other languages
English (en)
Other versions
ES495971A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda Pharmaceutical Co Ltd
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Publication of ES8107206A1 publication Critical patent/ES8107206A1/es
Publication of ES495971A0 publication Critical patent/ES495971A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/44—Acylated amino or imino radicals
    • C07D277/46—Acylated amino or imino radicals by carboxylic acids, or sulfur or nitrogen analogues thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/40—Unsubstituted amino or imino radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/42—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)

Abstract

PROCEDIMIENTO DE OBTENCION DE DERIVADOS DE TIAZOL DE FORMULA (I), DONDE X ES HIDROGENO, HALOGENO, ALCOHILO INFERIOR O TRIFLUOROMETILO; R ES HIDROGENO, ALCOHILO INFERIOR O ACILO INFERIOR, Y N VALE 1 O 2. SE HACE REACCIONAR 1 MOL DE UN COMPUESTO DE FORMULA (II), DONDE Y ES HALOGENO, CON 1-2MOLES DE UN COMPUESTO DE FORMULA (III), EN PRESENCIA DE DISOLVENTES COMO ALCOHOLES O ETERES, A TEMPERATURA AMBIENTE O EN EL PUNTO DE EBULLICION DEL DISOLVENTE. SE AISLA EL PRODUCTO FINAL POR CONCENTRACION BAJO VACIO, EXTRACCION CON DISOLVENTE, CONCENTRACION, CRISTALIZACION U OTROS METODOS. SE OBTIENE UNA SAL ACIDA, CASO DE SER R UN GRUPO ACILO INFERIOR, O UNA AMINA LIBRE, POR TRATAMIENTO CON UNA BASE ADECUADA. DE APLICACION EN EL TRATAMIENTO DE LA HIPERLIPEMIA, ARTEROESCLEROSIS Y ENFERMEDADES DEL CORAZON ATRIBUIBLES A ELLA, EN MAMIFEROS. *FORMULA* E
ES495971A 1979-10-17 1980-10-16 Procedimiento para obtener derivados de tiazol Granted ES495971A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP13448979A JPS5657775A (en) 1979-10-17 1979-10-17 Thiazole derivative

Publications (2)

Publication Number Publication Date
ES8107206A1 true ES8107206A1 (es) 1981-10-01
ES495971A0 ES495971A0 (es) 1981-10-01

Family

ID=15129514

Family Applications (1)

Application Number Title Priority Date Filing Date
ES495971A Granted ES495971A0 (es) 1979-10-17 1980-10-16 Procedimiento para obtener derivados de tiazol

Country Status (6)

Country Link
US (1) US4348403A (es)
EP (1) EP0027957A1 (es)
JP (1) JPS5657775A (es)
DK (1) DK438180A (es)
ES (1) ES495971A0 (es)
GR (1) GR70379B (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0320501A3 (en) * 1983-06-24 1989-12-06 Yamanouchi Pharmaceutical Co., Ltd. Phenoxy derivatives, their preparation, and pharmaceutical compositions containing them
DK305884A (da) * 1983-06-24 1984-12-25 Yamanouchi Pharma Co Ltd Phenoxyderivat, fremgangsmaade til fremstilling deraf og farmaceutisk praeparat indeholdende et saadant derivat
DE69738809D1 (de) * 1996-11-08 2008-08-14 Nippon Chemiphar Co Mittel zur verringerung der eigeweidefette
KR20050119201A (ko) * 2003-04-09 2005-12-20 니뽄 다바코 산교 가부시키가이샤 ５원 헤테로방향족 고리 화합물 및 이의 의약적 용도
CN102807586B (zh) 2012-08-31 2015-05-13 东北制药集团股份有限公司 磷霉素氨盐的制备方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1743083A (en) * 1928-02-03 1930-01-07 Winthrop Chem Co Catechol thiazoles and process of making the same
FR1567911A (es) * 1967-10-06 1969-05-23
CH533420A (de) * 1970-06-23 1973-02-15 Agripat Sa Mittel zur Regulierung des Pflanzenwachstums und zur Erhöhung des Zuckergehaltes in Zuckerrohr
DE2132431A1 (de) * 1971-06-30 1973-01-11 Riedel De Haen Ag 4-phenyl-thiazolderivate enthaltende pharmazeutische praeparate
US4074057A (en) * 1973-12-12 1978-02-14 Takeda Chemical Co., Ltd. 2-Halopropionic acid and its derivatives
PT65179B (en) * 1975-06-09 1977-11-18 Takeda Chemical Industries Ltd Alpha/chlorocarboxylic acids

Also Published As

Publication number Publication date
DK438180A (da) 1981-04-18
GR70379B (es) 1982-10-04
US4348403A (en) 1982-09-07
EP0027957A1 (en) 1981-05-06
JPS5657775A (en) 1981-05-20
ES495971A0 (es) 1981-10-01

Similar Documents

Publication Publication Date Title
DE3272792D1 (en) Process for the preparation of 2-penem compounds
PH17740A (en) Substituted acyl derivatives of 1-2,3,4 tetrahydro-isoquinoline-3-carboxylic acids,their pharmaceutical compositions and use
PH15864A (en) 2-(2-alkoxy-methyl)-2-hydroxy-6-7 benzomorphans and salts thereof
YU16893A (sh) Derivati diarilsulfonamida i postupak za njihovo dobijanje
NO173867C (no) Analogifremgangsmaate for fremstilling av terapeutisk aktive benzamider
ES479820A1 (es) Procedimiento para la preparacion de isoquinoleinas.
FR2443471A1 (fr) Derives du type thiazolidine de la progesterone utiles notamment comme precurseurs de medicaments antiacne et antiseborrhee
ES8107206A1 (es) Procedimiento para obtener derivados de tiazol
ES481551A1 (es) Procedimiento de preparacion de nuevos compuestos bis (ari- loxicarboxilicos).
ES480827A1 (es) Procedimiento para la preparacion de acidos fenilaminotiofe-noaceticos.
ZA807819B (en) Benzothiazole derivatives, pharmaceutical formulations containing them and a process for their preparation
DE3261515D1 (en) Benzopyranyl ethers, process for their preparation and medicine containing those compounds and intermediates
IL69734A (en) 1-phenyl-1-aminomethyl cyclobutane derivatives,process for their preparation and pharmaceutical compositions containing them
ES474367A1 (es) Procedimiento de preparacion de nuevos derivados del benzo- (d)tiazol.
ES466192A1 (es) Procedimiento para la obtencion de derivados de la isoqui- noleina.
JPS57171972A (en) Manufacture of quinoline-4-ones
DE3069173D1 (en) Substituted phenylamino-2-imidazoline-2 derivatives, their acid addition salts, medicaments containing them and process for their preparation
ES8500919A1 (es) Un metodo para preparar derivados de tiazolidina.
NZ216125A (en) Isoxazoles and pharmaceutical compositions
JPS55162785A (en) Novel xanthine derivative* its manufacture and allurgy therapeutic agent containing same
IE790754L (en) Substituted ethanolamines
ZA811585B (en) Anti-inflammatory compositions
ES474985A1 (es) Procedimiento para la preparacion de derivados de la isoqui-noleina
GB2006196A (en) Phenylacetamides with analgesic activity
DE3068274D1 (en) Corticoid-17-thioacetals, their preparation and use