ES8107201A1 - Un procedimiento para la preparacion de derivados de morfo- lina - Google Patents
Un procedimiento para la preparacion de derivados de morfo- linaInfo
- Publication number
- ES8107201A1 ES8107201A1 ES496074A ES496074A ES8107201A1 ES 8107201 A1 ES8107201 A1 ES 8107201A1 ES 496074 A ES496074 A ES 496074A ES 496074 A ES496074 A ES 496074A ES 8107201 A1 ES8107201 A1 ES 8107201A1
- Authority
- ES
- Spain
- Prior art keywords
- lower alkyl
- morpholine derivatives
- processes
- preparation
- pharmaceutical compositions
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
- C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
- C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
- C07D265/32—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings with oxygen atoms directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
- C07D303/18—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by etherified hydroxyl radicals
- C07D303/20—Ethers with hydroxy compounds containing no oxirane rings
- C07D303/22—Ethers with hydroxy compounds containing no oxirane rings with monohydroxy compounds
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Lubricants (AREA)
- Signal Processing For Digital Recording And Reproducing (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS DE MORFOLINA DE FORMULA GENERAL (I) Y SUS SALES DE ADICION DE ACIDO FARMACEUTICAMENTE ACEPTABLES. CONSISTENTE EN OBTENER EL COMPUESTO (I) A PARTIR DE OTROS INTERMEDIOS PREPARADOS A SU VEZ POR CICLIZACION, CONDENSACION, ETC., DE OTROS MAS SENCILLOS POR METODOS EN SI CONOCIDOS. ASI, EN UNA REALIZACION PREFERENTE, SE OBTIENE (I) POR REDUCCION DEL COMPUESTO DE FORMULA (II) O POR CICLODESHIDRATACION DEL DIOL (III), EN CUYAS FORMULAS SE TIENEN LOS SIGNIFICADOS SIGUIENTES. R1 ES ALQUILO INFERIOR; R2 ES HIDROGENO, ALQUILO INFERIOR, BENCILO, ALCOXIMETILO (INFERIOR) O UN GRUPO DE ACILO; R3 ES HIDROGENO, ALQUILO INFERIOR O FENILO; R4, R5 Y R6 SON, INDEPENDIENTEMENTE, HIDROGENO, O ALQUILO INFERIOR, Y R7 ES HIDROGENO, ALQUILO INFERIOR, ALQUENILO INFERIOR, ALQUINILO INFERIOR, ARIL-ALQUILO (INFERIOR), 2-TETRAHIDROFURILMETILO O CICLOALQUILMETILO. EN CUALQUIERA DE LAS REACCIONES QUE SE UTILICEN, LAS CONDICIONES DE LAS MISMAS SE ELIGEN CON RESPECTO A LA REACTIVIDAD Y ESTABILIDAD DE LOS SUSTITUYENTES, DE MODO QUE SE OBTENGA EL PRODUCTO DESEADO. LOS COMPUESTOS OBTENIDOS POSEEN ACTIVIDAD FARMACOLOGICA, EN PARTICULAR ACTIVIDAD ANALGESICA Y/O ACTIVIDAD ANTAGONISTA OPIACEA. *FORMULA*
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB7936502 | 1979-10-20 |
Publications (2)
Publication Number | Publication Date |
---|---|
ES8107201A1 true ES8107201A1 (es) | 1981-10-01 |
ES496074A0 ES496074A0 (es) | 1981-10-01 |
Family
ID=10508675
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES496074A Granted ES496074A0 (es) | 1979-10-20 | 1980-10-18 | Un procedimiento para la preparacion de derivados de morfo- lina |
Country Status (17)
Country | Link |
---|---|
US (1) | US4360519A (es) |
EP (1) | EP0027695B1 (es) |
JP (1) | JPS5665880A (es) |
KR (2) | KR840002427B1 (es) |
AT (1) | ATE4980T1 (es) |
AU (1) | AU531586B2 (es) |
CA (1) | CA1126731A (es) |
DE (1) | DE3065304D1 (es) |
DK (1) | DK151800C (es) |
ES (1) | ES496074A0 (es) |
FI (1) | FI803277L (es) |
GB (1) | GB2061272B (es) |
GR (1) | GR70235B (es) |
IE (1) | IE50355B1 (es) |
MY (1) | MY8500468A (es) |
PT (1) | PT71940B (es) |
ZA (1) | ZA806017B (es) |
Families Citing this family (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2125793B (en) * | 1982-08-19 | 1985-10-02 | Wyeth John & Brother Ltd | Morpholine derivatives |
GB8305638D0 (en) * | 1983-03-01 | 1983-03-30 | Wyeth John & Brother Ltd | Morpholine derivatives |
FR2553412B1 (fr) * | 1983-10-17 | 1986-03-21 | Lafon Labor | Derives de 4-alkyl-2-methyl-2-phenyl-morpholine, procede de preparation et utilisation en therapeutique |
GB8418657D0 (en) * | 1984-07-21 | 1984-08-22 | Beecham Group Plc | Compounds |
FR2581383A1 (fr) * | 1985-05-03 | 1986-11-07 | Cerm Cent Europ Rech Mauvernay | 2-alkyl-2-aryl morpholines substituees, leur preparation et les compositions pharmaceutiques les contenant |
DE3621775A1 (de) * | 1986-03-13 | 1988-01-07 | Thomae Gmbh Dr K | Neue substituierte thiazole und oxazole, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung |
GB9108629D0 (en) * | 1991-04-23 | 1991-06-12 | Wellcome Found | Heterocyclic pharmaceutical compounds,preparation and use |
US6048859A (en) | 1992-06-29 | 2000-04-11 | Merck & Co., Inc. | Morpholine and thiomorpholine tachykinin receptor antagonists |
US5637699A (en) * | 1992-06-29 | 1997-06-10 | Merck & Co., Inc. | Process for preparing morpholine tachykinin receptor antagonists |
US5719147A (en) * | 1992-06-29 | 1998-02-17 | Merck & Co., Inc. | Morpholine and thiomorpholine tachykinin receptor antagonists |
IL112778A0 (en) * | 1994-03-04 | 1995-05-26 | Merck & Co Inc | Substituted heterocycles, their preparation and pharmaceutical compositions containing them |
KR20050088194A (ko) * | 2002-12-19 | 2005-09-02 | 머크 앤드 캄파니 인코포레이티드 | 치환된 아미드 |
MXPA05013364A (es) | 2003-06-17 | 2006-03-17 | Arena Pharm Inc | Procedimiento para preparar 3-benzazepinas. |
WO2007120517A2 (en) | 2006-04-03 | 2007-10-25 | Arena Pharmaceuticals, Inc. | Processes for the preparation of 8-chloro-1-methyl-2,3,4,5-tetrahydro-1h-3-benzazepine and intermediates related thereto |
JP5404414B2 (ja) | 2006-12-05 | 2014-01-29 | アリーナ ファーマシューティカルズ, インコーポレイテッド | (r)−8−クロロ−1−メチル−2,3,4,5−テトラヒドロ−1h−3−ベンゾアゼピンおよびその中間体を調製するための方法 |
WO2009111004A1 (en) | 2008-03-04 | 2009-09-11 | Arena Pharmaceuticals, Inc. | Processes for the preparation of intermediates related to the 5-ht2c agonist (r)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1h-3-benzazepine |
WO2010148207A2 (en) | 2009-06-18 | 2010-12-23 | Arena Pharmaceuticals, Inc. | Processes for the preparation of 5-ht2c receptor agonists |
JP5952267B2 (ja) | 2010-05-21 | 2016-07-13 | リサーチ・トライアングル・インスティチュート | 薬物依存を処置するためのヒドロキシブプロピオン類似体(政府支援研究または開発) |
CA2800220C (en) | 2010-05-21 | 2019-04-30 | Research Triangle Institute | Phenylmorpholines and analogues thereof |
US9045431B2 (en) | 2010-06-02 | 2015-06-02 | Arena Pharmaceuticals, Inc. | Processes for the preparation of 5-HT2C receptor agonists |
WO2012030939A1 (en) | 2010-09-01 | 2012-03-08 | Arena Pharmaceuticals, Inc. | Administration of lorcaserin to individuals with renal impairment |
WO2012030938A1 (en) | 2010-09-01 | 2012-03-08 | Arena Pharmaceuticals, Inc. | Salts of lorcaserin with optically active acids |
KR101913442B1 (ko) | 2010-09-01 | 2018-10-30 | 에자이 알앤드디 매니지먼트 가부시키가이샤 | 체중 관리에 유용한 5-ht2c 작동제의 변형-방출 투여 형태 |
MX2013002421A (es) | 2010-09-01 | 2013-05-17 | Arena Pharm Inc | Sales no hidroscopicas de agonistas de 5-ht2c. |
AU2012392187B2 (en) | 2012-10-09 | 2018-07-12 | Arena Pharmaceuticals, Inc. | Method of weight management |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2997469A (en) * | 1961-08-22 | Preparation of substituted | ||
US2835669A (en) * | 1958-05-20 | Process for the production of substi- | ||
US3112311A (en) * | 1957-04-05 | 1963-11-26 | Geigy Chem Corp | 2-phenyl-5, 6-dimethyl-morpholines and 2-phenyl-5, 6-tetramethylene-morpholines |
US3296076A (en) * | 1962-06-11 | 1967-01-03 | Boehringer Sohn Ingelheim | Pilomotor shaving compositions and method of using same |
GB1336732A (en) * | 1970-10-28 | 1973-11-07 | Istituto Gentili Spa Pisa | Diethanolamine derivatives |
GB1452701A (en) * | 1974-05-07 | 1976-10-13 | Ici Ltd | Morpholine derivatives |
-
1980
- 1980-09-24 IE IE1995/80A patent/IE50355B1/en unknown
- 1980-09-29 ZA ZA00806017A patent/ZA806017B/xx unknown
- 1980-10-01 CA CA361,904A patent/CA1126731A/en not_active Expired
- 1980-10-02 AU AU62922/80A patent/AU531586B2/en not_active Ceased
- 1980-10-02 GB GB8031816A patent/GB2061272B/en not_active Expired
- 1980-10-02 AT AT80303473T patent/ATE4980T1/de not_active IP Right Cessation
- 1980-10-02 GR GR63034A patent/GR70235B/el unknown
- 1980-10-02 DE DE8080303473T patent/DE3065304D1/de not_active Expired
- 1980-10-02 EP EP80303473A patent/EP0027695B1/en not_active Expired
- 1980-10-03 US US06/193,779 patent/US4360519A/en not_active Expired - Lifetime
- 1980-10-17 JP JP14556480A patent/JPS5665880A/ja active Pending
- 1980-10-17 DK DK441080A patent/DK151800C/da not_active IP Right Cessation
- 1980-10-17 FI FI803277A patent/FI803277L/fi not_active Application Discontinuation
- 1980-10-18 ES ES496074A patent/ES496074A0/es active Granted
- 1980-10-18 KR KR1019800003997A patent/KR840002427B1/ko active
- 1980-10-20 PT PT71940A patent/PT71940B/pt unknown
-
1984
- 1984-10-06 KR KR1019840006196A patent/KR840002428B1/ko not_active IP Right Cessation
-
1985
- 1985-12-30 MY MY468/85A patent/MY8500468A/xx unknown
Also Published As
Publication number | Publication date |
---|---|
PT71940A (en) | 1980-11-01 |
IE801995L (en) | 1981-04-20 |
GB2061272A (en) | 1981-05-13 |
MY8500468A (en) | 1985-12-31 |
PT71940B (pt) | 1981-08-31 |
AU531586B2 (en) | 1983-09-01 |
IE50355B1 (en) | 1986-04-02 |
ES496074A0 (es) | 1981-10-01 |
JPS5665880A (en) | 1981-06-03 |
FI803277L (fi) | 1981-04-21 |
EP0027695A1 (en) | 1981-04-29 |
EP0027695B1 (en) | 1983-10-12 |
ATE4980T1 (de) | 1983-10-15 |
ZA806017B (en) | 1982-04-28 |
US4360519A (en) | 1982-11-23 |
DK151800C (da) | 1988-06-06 |
KR840002428B1 (ko) | 1984-12-27 |
AU6292280A (en) | 1981-04-30 |
CA1126731A (en) | 1982-06-29 |
GB2061272B (en) | 1983-08-10 |
KR830004277A (ko) | 1983-07-09 |
DE3065304D1 (en) | 1983-11-17 |
GR70235B (es) | 1982-09-01 |
KR840002427B1 (ko) | 1984-12-27 |
DK151800B (da) | 1988-01-04 |
DK441080A (da) | 1981-04-21 |
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