ES8106718A1 - Un procedimiento para la preparacion de derivados del 2,3- dihidro-5- acilbenzofuranos 2,6,7- trisustituidos. - Google Patents

Un procedimiento para la preparacion de derivados del 2,3- dihidro-5- acilbenzofuranos 2,6,7- trisustituidos.

Info

Publication number
ES8106718A1
ES8106718A1 ES492666A ES492666A ES8106718A1 ES 8106718 A1 ES8106718 A1 ES 8106718A1 ES 492666 A ES492666 A ES 492666A ES 492666 A ES492666 A ES 492666A ES 8106718 A1 ES8106718 A1 ES 8106718A1
Authority
ES
Spain
Prior art keywords
acylbenzofurans
trisubstituted
dihydro
same
pharmaceutical compositions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES492666A
Other languages
English (en)
Other versions
ES492666A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of ES492666A0 publication Critical patent/ES492666A0/es
Publication of ES8106718A1 publication Critical patent/ES8106718A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/80—Radicals substituted by oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Furan Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS DEL 2,3-DIHIDRO-5-ACILBENZOFURANO 2,6,7-TRISUSTITUIDO, DE FORMULA (I), EN LA QUE X ES HALOGENO O RADICAL METILO; Y ES HALOGENO, METILO O HIDROGENO, O X E Y PUEDEN FORMAR UN RADICAL HIDROCARBILENO C3-4; R PUEDE SER UNO DE VARIOS RADICALES CICLICOS O HETEROCICLICOS, Y Z PUEDE SER UNO DE VARIOS RADICALES QUE CONTIENEN OXIGENO O NITROGENO. SE BASA EN LA REACCION DE REDUCCION DEL COMPUESTO DE FORMULA (II), EN LA QUE R, X E Y TIENE LA MISMA SIGNIFICACION QUE EN LA FORMULA (I) Y R2 ES UN RADICAL ALQUILO C1-4, CON UN HIDRURO METALICO COMPLEJO EN TETRAHIDROFURANO, TOLUENO O ETER, A UNA TEMPERATURA COMPRENDIDA ENTRE -50 G Y 70 GC. ESTOS COMPUESTOS TIENEN APLICACIONES FISIOLOGICAS POR SU ACTIVIDAD DIURETICA-SALURETICA, URICOSURICA Y ANTIHIPERTENSIVA. *FORMULA*
ES492666A 1979-06-21 1980-06-20 Un procedimiento para la preparacion de derivados del 2,3- dihidro-5- acilbenzofuranos 2,6,7- trisustituidos. Expired ES8106718A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/050,852 US4237144A (en) 1979-06-21 1979-06-21 2,3-Dihydro-2,6,7-trisubstituted-5-acylbenzofurans

Publications (2)

Publication Number Publication Date
ES492666A0 ES492666A0 (es) 1981-09-01
ES8106718A1 true ES8106718A1 (es) 1981-09-01

Family

ID=21967884

Family Applications (1)

Application Number Title Priority Date Filing Date
ES492666A Expired ES8106718A1 (es) 1979-06-21 1980-06-20 Un procedimiento para la preparacion de derivados del 2,3- dihidro-5- acilbenzofuranos 2,6,7- trisustituidos.

Country Status (7)

Country Link
US (1) US4237144A (es)
EP (1) EP0021346A1 (es)
JP (1) JPS5636485A (es)
DK (1) DK262980A (es)
ES (1) ES8106718A1 (es)
GR (1) GR69242B (es)
PT (1) PT71404B (es)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4435422A (en) * 1982-09-15 1984-03-06 Abbott Laboratories 5-Substituted 2,3-dihydrobenzofuran-2-carboxylic acids and their use in diuretic compositions
US4495199A (en) * 1982-09-30 1985-01-22 Ribalta Jose Miguel B Dioxolanic amine with pharmacological activity, its method of preparation, the pharmaceutical compositions containing same and their use in human medicine
US4490384A (en) * 1983-02-23 1984-12-25 Abbott Laboratories Benzisoxazole carboxylic acids
FI842738A (fi) * 1983-07-14 1985-01-15 Syntex Inc Aroylbenzofuran- och benzotiofenaettik- och propionsyror.
US4617407A (en) * 1984-08-30 1986-10-14 Merck Frosst Canada, Inc. Leukotriene antagonists
US4654365A (en) * 1985-09-26 1987-03-31 Merck & Co., Inc. 2,3-dihydro-5-(3-oxo-2-cyclohexen-1-yl)-2-benzofurancarboxylic acids, and their salts useful in the treatment of brain injury
US6969730B2 (en) * 2001-03-16 2005-11-29 Abbott Laboratories Amines as histamine-3 receptor ligands and their therapeutic applications
MXPA03008319A (es) * 2001-03-16 2003-12-11 Abbott Lab Nuevas aminas como ligantes del receptor de histamina-3 y sus aplicaciones terapeuticas.
US6858615B2 (en) 2002-02-19 2005-02-22 Parion Sciences, Inc. Phenyl guanidine sodium channel blockers
US6858614B2 (en) * 2002-02-19 2005-02-22 Parion Sciences, Inc. Phenolic guanidine sodium channel blockers
US6903105B2 (en) 2003-02-19 2005-06-07 Parion Sciences, Inc. Sodium channel blockers
US7745442B2 (en) 2003-08-20 2010-06-29 Parion Sciences, Inc. Methods of reducing risk of infection from pathogens
US7435837B2 (en) * 2003-10-24 2008-10-14 Wyeth Dihydrobenzofuranyl alkanamine derivatives and methods for using same
US20050261347A1 (en) * 2003-10-24 2005-11-24 Wyeth Dihydrobenzofuranyl alkanamine derivatives and methods for using same
AR086745A1 (es) 2011-06-27 2014-01-22 Parion Sciences Inc 3,5-diamino-6-cloro-n-(n-(4-(4-(2-(hexil(2,3,4,5,6-pentahidroxihexil)amino)etoxi)fenil)butil)carbamimidoil)pirazina-2-carboxamida
AU2013363215B2 (en) 2012-12-17 2018-03-01 Parion Sciences, Inc. 3,5-diamino-6-chloro-N-(N-(4-phenylbutyl)carbamimidoyl) pyrazine-2- carboxamide compounds
EP3150585A1 (en) 2012-12-17 2017-04-05 Parion Sciences, Inc. Chloro-pyrazine carboxamide derivatives with epithelial sodium channel blocking activity
US9102633B2 (en) 2013-12-13 2015-08-11 Parion Sciences, Inc. Arylalkyl- and aryloxyalkyl-substituted epithelial sodium channel blocking compounds

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH508615A (de) * 1968-05-30 1971-06-15 Ciba Geigy Ag Verfahren zur Herstellung von neuen heterocyclischen Carbonsäuren
US4087542A (en) * 1975-07-09 1978-05-02 Merck & Co., Inc. 2,3-Dihydro-6,7-disubstituted-5-acyl benzofuran-2-carboxylic acids
US4181727A (en) * 1975-07-09 1980-01-01 Merck & Co., Inc. 2,3-Dihydro-6,7-disubstituted-5-acyl benzofuran-2-carboxylic acids
US4085117A (en) * 1976-10-18 1978-04-18 Merck & Co., Inc. 6,7-Disubstituted-5-(acyl)benzofuran-2-carboxylic acids

Also Published As

Publication number Publication date
US4237144A (en) 1980-12-02
DK262980A (da) 1980-12-22
JPS5636485A (en) 1981-04-09
ES492666A0 (es) 1981-09-01
PT71404A (en) 1980-07-01
GR69242B (es) 1982-05-11
EP0021346A1 (en) 1981-01-07
PT71404B (en) 1981-10-22

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