ES8105254A1 - Un procedimiento para la preparacion de acido 2-(4-dimetil- vinilfenil) propionico - Google Patents

Un procedimiento para la preparacion de acido 2-(4-dimetil- vinilfenil) propionico

Info

Publication number
ES8105254A1
ES8105254A1 ES492556A ES492556A ES8105254A1 ES 8105254 A1 ES8105254 A1 ES 8105254A1 ES 492556 A ES492556 A ES 492556A ES 492556 A ES492556 A ES 492556A ES 8105254 A1 ES8105254 A1 ES 8105254A1
Authority
ES
Spain
Prior art keywords
alkanoic acid
acid compound
dehydration
esters
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES492556A
Other languages
English (en)
Other versions
ES492556A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glaxo Group Ltd
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of ES8105254A1 publication Critical patent/ES8105254A1/es
Publication of ES492556A0 publication Critical patent/ES492556A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/42—Unsaturated compounds containing hydroxy or O-metal groups
    • C07C59/48—Unsaturated compounds containing hydroxy or O-metal groups containing six-membered aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
    • C07C45/46—Friedel-Crafts reactions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/80—Ketones containing a keto group bound to a six-membered aromatic ring containing halogen
    • C07C49/807—Ketones containing a keto group bound to a six-membered aromatic ring containing halogen all halogen atoms bound to the ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/52—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen
    • C07C57/58—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/52—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen
    • C07C57/58—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen containing six-membered aromatic rings
    • C07C57/60—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen containing six-membered aromatic rings having unsaturation outside the rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

PROCEDIMIENTO DE OBTENCION DE ACIDO 2-(4-DIMETILVINILFENIL)PROPIONICO. CONSISTE EN DESHIDRATAR UN COMPUESTO DE FORMULA GENERAL (I), DONDE R REPRESENTA UN ATOMO DE HIDROGENO O UN GRUPO ALQUILO C1-4 ALCOHOIL (C2-5) OXIMETILO. CUANDO R ES UN ATOMO DE HIDROGENO, OPCIONALMENTE, LA DESHIDRATACION SE EFECTUA EN PRESENCIA DE UN ALCANOL C1-4, Y SI SE DESEA SE CONVIERTE EL ACIDO OBTENIDO EN LA SAL FISIOLOGICAMENTE ACEPTABLE, TAL COMO LA SAL DE CALCIO O DE D1-LISINA DEL ACIDO 2-(4-DIMETILVINILFENIL)PROPIONICO. *FORMULA* ACTIVIDAD ANTI-INFLAMATORIA. I
ES492556A 1979-06-18 1980-06-18 Un procedimiento para la preparacion de acido 2-(4-dimetil- vinilfenil) propionico Granted ES492556A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB7921083 1979-06-18

Publications (2)

Publication Number Publication Date
ES8105254A1 true ES8105254A1 (es) 1981-06-01
ES492556A0 ES492556A0 (es) 1981-06-01

Family

ID=10505908

Family Applications (1)

Application Number Title Priority Date Filing Date
ES492556A Granted ES492556A0 (es) 1979-06-18 1980-06-18 Un procedimiento para la preparacion de acido 2-(4-dimetil- vinilfenil) propionico

Country Status (10)

Country Link
US (1) US4362891A (es)
JP (1) JPS5639039A (es)
CH (1) CH646935A5 (es)
DE (1) DE3022599A1 (es)
ES (1) ES492556A0 (es)
FR (1) FR2459219A1 (es)
GB (1) GB2055363B (es)
GR (1) GR68764B (es)
IT (2) IT1143921B (es)
PT (1) PT71405B (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57203035A (en) * 1981-06-05 1982-12-13 Taisho Pharmaceut Co Ltd Carboxylic acid ester
JPS58225039A (ja) * 1982-06-22 1983-12-27 Eisai Co Ltd ポリプレニル系化合物
DE3360677D1 (en) * 1982-11-11 1985-10-03 Beecham Group Plc Arachidonic acid analogues, processes for their preparation and their use in medicine
JPS59212439A (ja) * 1983-05-19 1984-12-01 Taisho Pharmaceut Co Ltd スチレン誘導体
US4499300A (en) * 1983-12-27 1985-02-12 Uop Inc. 4-Vinylbenzeneacetic acid
US5244920A (en) * 1985-04-15 1993-09-14 Schering Spa Pharmaceutical compositions having therapeutical activity based on mercaptoethansulphonic arginine salt
IT1185551B (it) * 1985-04-15 1987-11-12 Schering Spa Composizioni farmaceutiche a base di acido mercaptoetansolfonico ad attivita' terapeutica,derivati salini organici dell'acido mercaptoetansolfonico utili per tali composizioni e relativo procedimento di preparazione

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3385887A (en) * 1961-02-02 1968-05-28 Boots Pure Drug Co Ltd 4-isobutylphenylacetic acid
GB971700A (en) * 1961-02-02 1964-09-30 Boots Pure Drug Co Ltd Anti-Inflammatory Agents
GB1012480A (en) 1962-07-26 1965-12-08 Boots Pure Drug Co Ltd Anti-inflammatory agents
US3397225A (en) * 1964-06-15 1968-08-13 Union Oil Co Preparation of esters of unsaturated acids
CH474469A (fr) * 1966-09-08 1969-06-30 Boots Pure Drug Co Ltd Procédé de préparation d'acides a-phénylpropioniques
US3652608A (en) * 1968-09-20 1972-03-28 Union Oil Co Preparation of unsaturated esters
US3729509A (en) * 1970-04-20 1973-04-24 Merck & Co Inc (mono-and diacylvinyl)aryl alkanoic(and alkenoic)acids
US3649668A (en) * 1970-06-15 1972-03-14 Dow Chemical Co Halogen containing esters of vinyl arylene acetic acid
GB1459084A (en) * 1973-05-24 1976-12-22 Boots Co Ltd Preparation of arylalkanoic acid
IT1059677B (it) * 1974-03-22 1982-06-21 Neopharmed Spa Sale di lisina ad azione terapeutica
JPS54163545A (en) * 1978-06-10 1979-12-26 Taisho Pharmaceutical Co Ltd Organic carboxylic acid derivative

Also Published As

Publication number Publication date
PT71405B (en) 1981-10-22
GR68764B (es) 1982-02-17
IT1143921B (it) 1986-10-29
IT8048996A0 (it) 1980-06-17
IT1128163B (it) 1986-05-28
GB2055363B (en) 1983-04-13
CH646935A5 (de) 1984-12-28
IT8048995A0 (it) 1980-06-17
DE3022599A1 (de) 1981-01-08
FR2459219B1 (es) 1983-11-25
FR2459219A1 (fr) 1981-01-09
PT71405A (en) 1980-07-01
JPS5639039A (en) 1981-04-14
US4362891A (en) 1982-12-07
GB2055363A (en) 1981-03-04
ES492556A0 (es) 1981-06-01

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