GB1138460A - Steroid compounds - Google Patents
Steroid compoundsInfo
- Publication number
- GB1138460A GB1138460A GB2338766A GB2338766A GB1138460A GB 1138460 A GB1138460 A GB 1138460A GB 2338766 A GB2338766 A GB 2338766A GB 2338766 A GB2338766 A GB 2338766A GB 1138460 A GB1138460 A GB 1138460A
- Authority
- GB
- United Kingdom
- Prior art keywords
- alkyl
- give
- gona
- alkoxy
- ones
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J75/00—Processes for the preparation of steroids in general
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Steroid Compounds (AREA)
Abstract
1,138,460. 13#-(C 2-5 alkyl)-gonane compounds. MERCK & CO. Inc. 25 May, 1966 [1 June, 1965], No. 23387/66. Heading C2U. [Also in Division A5] Novel steroids of the formulµ (wherein R 1 is ethyl, isopropyl, n-butyl, isobutyl, n-pentyl, or isopentyl; and R 2 is C 1-5 alkyl) are prepared by ethynylating a 3-alkoxy- 13# - alkyl - gona - 1,3,5(10) - trien - 17 - one to give the corresponding 17α-ethynyl-17#-ol, converting this to the 17-acetate, brominating this with N-bromoacetamide to give the 17α-dibromocacetyl-17#-acetoxy compound, debrominating this with zinc dust and an aliphatic acid to give the 17α-acetyl-17#-acetoxy compound, reducing this with lithium or sodium in liquid ammonia to give compound VI, treating this with methanolic HCl to give compound VII, and oxidizing this to compound VIII. 3 - Alkoxy - 13# - alkyl - gona - 1,3,5(10) - trien- 17-ones are prepared by catalytically hydrogenating 3 - alkoxy - 13# - alkyl - gona - 1,3,5(10),8,14 - pentaen - 17 - ones to give 3 - alkoxy - 13# - alkyl - gona - 1,3,5(10),8 - tetraen- 17-ones, treating these with methanolic HCl to give 3 - alkoxy - 13# - alkyl - gona - 1,3,5(10), 9(11) - tetraen-17-ones and catalytically hydrogenating these. Reference has been directed by the Comptroller to Specification 1,084,164.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US46050465A | 1965-06-01 | 1965-06-01 |
Publications (1)
Publication Number | Publication Date |
---|---|
GB1138460A true GB1138460A (en) | 1969-01-01 |
Family
ID=23828976
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB2338766A Expired GB1138460A (en) | 1965-06-01 | 1966-05-25 | Steroid compounds |
Country Status (5)
Country | Link |
---|---|
BR (1) | BR6680057D0 (en) |
CH (1) | CH473106A (en) |
DE (1) | DE1593030A1 (en) |
GB (1) | GB1138460A (en) |
NL (1) | NL6607588A (en) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2444047A1 (en) * | 1978-12-13 | 1980-07-11 | Roussel Uclaf | NOVEL 2,2-DIMETHYL 19-NOR STEROIDS DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR APPLICATION AS MEDICAMENTS |
-
1966
- 1966-05-25 GB GB2338766A patent/GB1138460A/en not_active Expired
- 1966-05-27 DE DE19661593030 patent/DE1593030A1/en active Pending
- 1966-05-31 CH CH782266A patent/CH473106A/en not_active IP Right Cessation
- 1966-05-31 BR BR18005766A patent/BR6680057D0/en unknown
- 1966-06-01 NL NL6607588A patent/NL6607588A/xx unknown
Also Published As
Publication number | Publication date |
---|---|
NL6607588A (en) | 1966-12-02 |
CH473106A (en) | 1969-05-31 |
BR6680057D0 (en) | 1973-12-26 |
DE1593030A1 (en) | 1970-07-23 |
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