ES435950A1 - Procedimiento de preparacion de acidos 4-aril-4-oxo-2-me- til-2-butenoicos y sus derivados amidicos. - Google Patents
Procedimiento de preparacion de acidos 4-aril-4-oxo-2-me- til-2-butenoicos y sus derivados amidicos.Info
- Publication number
- ES435950A1 ES435950A1 ES435950A ES435950A ES435950A1 ES 435950 A1 ES435950 A1 ES 435950A1 ES 435950 A ES435950 A ES 435950A ES 435950 A ES435950 A ES 435950A ES 435950 A1 ES435950 A1 ES 435950A1
- Authority
- ES
- Spain
- Prior art keywords
- keto acids
- reducing cholesterol
- certain aromatic
- aromatic keto
- certain
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/76—Unsaturated compounds containing keto groups
- C07C59/84—Unsaturated compounds containing keto groups containing six membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/76—Unsaturated compounds containing keto groups
- C07C59/86—Unsaturated compounds containing keto groups containing six-membered aromatic rings and other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/76—Unsaturated compounds containing keto groups
- C07C59/88—Unsaturated compounds containing keto groups containing halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/76—Unsaturated compounds containing keto groups
- C07C59/90—Unsaturated compounds containing keto groups containing singly bound oxygen-containing groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Steroid Compounds (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR7410196A FR2265409A1 (en) | 1974-03-25 | 1974-03-25 | 4-Oxo-4-phenyl-2-methyl(ene)-butyric acid derivs. - analgesics, antiinflammatories and hypocholesterolemiants |
FR7504912A FR2300551A2 (fr) | 1975-02-17 | 1975-02-17 | Nouveaux |
Publications (1)
Publication Number | Publication Date |
---|---|
ES435950A1 true ES435950A1 (es) | 1976-12-16 |
Family
ID=26218246
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES435949A Expired ES435949A1 (es) | 1974-03-25 | 1975-03-24 | Procedimiento de prepracion de acidos 4-aril-4-oxo-2-meti- len-butricos. |
ES435950A Expired ES435950A1 (es) | 1974-03-25 | 1975-03-24 | Procedimiento de preparacion de acidos 4-aril-4-oxo-2-me- til-2-butenoicos y sus derivados amidicos. |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES435949A Expired ES435949A1 (es) | 1974-03-25 | 1975-03-24 | Procedimiento de prepracion de acidos 4-aril-4-oxo-2-meti- len-butricos. |
Country Status (5)
Country | Link |
---|---|
US (1) | US4008323A (es) |
CH (2) | CH595322A5 (es) |
DE (1) | DE2513157A1 (es) |
ES (2) | ES435949A1 (es) |
GB (1) | GB1498903A (es) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4271191A (en) * | 1979-12-19 | 1981-06-02 | Pierre Fabre S.A. | Method of treating hyperuricemia and gout |
FR2515037A1 (fr) * | 1981-10-22 | 1983-04-29 | Roussel Uclaf | A titre de medicaments, certains derives mono-substitues de l'acide 4-phenyl 4-oxo buten-2-oique, ainsi que les compositions les renfermant |
US4667055A (en) * | 1983-12-29 | 1987-05-19 | Merck Frosst Canada, Inc. | Leukotriene antagonists |
US4871756A (en) * | 1985-03-20 | 1989-10-03 | Merck Frosst Canada, Inc. | Leukotriene antagonists |
US5157022A (en) * | 1989-11-22 | 1992-10-20 | Adrian Barbul | Method for reducing blood cholesterol using arginine |
US5280045A (en) * | 1991-10-16 | 1994-01-18 | The Procter & Gamble Company | 4(3,5-bis(1,1-dimethylethyl-4-hydroxyphenyl)-4-oxobutanamide compound useful as an anti-inflammatory agent |
US7910624B1 (en) | 1995-03-03 | 2011-03-22 | The Trustees Of Boston University | Compositions for the treatment of blood disorders |
EP0731712A4 (en) * | 1993-10-29 | 2005-11-09 | Univ Boston | PHYSIOLOGICAL STABILIZED BUTTERIC ACID PREPARATIONS, AND BUTTERIC ACIDS AND DERIVATIVES AS ANTINEOPLASTIC ACTIVE SUBSTANCE |
US5789434A (en) * | 1994-11-15 | 1998-08-04 | Bayer Corporation | Derivatives of substituted 4-biarylbutyric acid as matrix metalloprotease inhibitors |
AR002945A1 (es) * | 1994-11-15 | 1998-05-27 | Bayer Corp | Acidos 4-biarilbutirico o 5-biarilpentanoico sustituidos y sus derivados como inhibidores de las metaloproteasas de matriz, composicion que los contiene, y metodos para la preparacion de dichos compuestos |
US6011000A (en) * | 1995-03-03 | 2000-01-04 | Perrine; Susan P. | Compositions for the treatment of blood disorders |
GB9522617D0 (en) * | 1995-11-03 | 1996-01-03 | Pharmacia Spa | 4-Phenyl-4-oxo-butenoic acid derivatives with kynurenine-3-hydroxylase inhibiting activity |
GB9522615D0 (en) * | 1995-11-03 | 1996-01-03 | Pharmacia Spa | 4-Phenyl-4-oxo-butanoic acid derivatives with kynurenine-3-hydroxylase inhibiting activity |
US6376546B1 (en) | 1997-10-14 | 2002-04-23 | Asahi Kasei Kabushiki Kaisha | Biphenyl-5-alkanoic acid derivatives and use thereof |
CA2324426A1 (en) * | 1998-02-11 | 1999-08-19 | Douglas V. Faller | Compositions and methods for the treatment of cystic fibrosis |
DE19835359A1 (de) * | 1998-08-05 | 2000-02-10 | Clariant Gmbh | Verfahren zur Herstellung von 4-(4'-Chlorbiphenyl-4-yl)-4-keto-2-methylenbuttersäure |
CA2503284A1 (en) * | 2002-10-24 | 2004-05-06 | Enos Pharmaceuticals, Inc. | Sustained release l-arginine formulations and methods of manufacture and use |
US20080145424A1 (en) * | 2002-10-24 | 2008-06-19 | Enos Phramaceuticals, Inc. | Sustained release L-arginine formulations and methods of manufacture and use |
EP1675619A4 (en) * | 2003-09-29 | 2010-10-06 | Palmetto Pharmaceuticals Llc | EXTENDED RELEASE ARGININE FORMULATIONS, METHODS OF MAKING, AND USES |
WO2010105112A1 (en) * | 2009-03-11 | 2010-09-16 | Hemaquest Pharmaceuticals, Inc. | Detection of short-chain fatty acids in biological samples |
WO2011038224A1 (en) | 2009-09-24 | 2011-03-31 | Trustees Of Boston University | Methods for treating viral disorders |
WO2011072086A1 (en) | 2009-12-08 | 2011-06-16 | Hemaquest Pharmaceuticals, Inc. | Methods and low dose regimens for treating red blood cell disorders |
US20110245154A1 (en) | 2010-03-11 | 2011-10-06 | Hemaquest Pharmaceuticals, Inc. | Methods and Compositions for Treating Viral or Virally-Induced Conditions |
SG11202113215UA (en) | 2019-05-31 | 2021-12-30 | Viracta Subsidiary Inc | Methods of treating virally associated cancers with histone deacetylase inhibitors |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3452081A (en) * | 1965-05-27 | 1969-06-24 | Merck & Co Inc | Phenoxy substituted 2-alkenoic acids |
GR37790B (el) | 1966-12-30 | 1969-07-15 | F. Hoffmann - La Roche & Co. Aktiengesellschaft | Μεθοδος δια την παρασκευην παραγωγων του αρουλακρυλικου οξεος. |
US3754021A (en) * | 1968-05-29 | 1973-08-21 | Merck & Co Inc | 4-keto-4-(3-chloro-4'-cyclohexyl)phenylbutyric acid and related compounds |
US3919304A (en) * | 1968-10-25 | 1975-11-11 | Ciba Geigy Corp | {62 -Hydroxy-{62 -(cycloalkenylphenyl)alkanoic acids, esters and salts |
BE759053A (fr) | 1969-11-17 | 1971-05-17 | Thomae Gmbh Dr K | Nouveaux acides hydroxycrotoniques et procedes pour les fabriquer |
US3784701A (en) * | 1970-09-21 | 1974-01-08 | American Cyanamid Co | Compositions containing substituted benzoylpropionic acids and method of use to treat inflammation and pain |
DE2103749A1 (en) * | 1971-01-27 | 1972-08-10 | Dr. Karl Thomae GmbH, 7951 Biberach | 3-acyl-acrylic acids prepn - from a ketone and glyoxylic acid (deriv) |
BE788749A (fr) * | 1971-09-13 | 1973-03-13 | Takeda Chemical Industries Ltd | Acide 3-(benzoyl trisubstitue)-propionique et son procede de preparation |
US3860722A (en) * | 1972-09-22 | 1975-01-14 | Richardson Merrell Inc | Hypolipidemic agents |
-
1975
- 1975-03-21 US US05/560,344 patent/US4008323A/en not_active Expired - Lifetime
- 1975-03-21 GB GB11888/75A patent/GB1498903A/en not_active Expired
- 1975-03-24 ES ES435949A patent/ES435949A1/es not_active Expired
- 1975-03-24 ES ES435950A patent/ES435950A1/es not_active Expired
- 1975-03-25 DE DE19752513157 patent/DE2513157A1/de active Granted
- 1975-03-25 CH CH383875A patent/CH595322A5/xx not_active IP Right Cessation
- 1975-03-25 CH CH383775A patent/CH596130A5/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
CH595322A5 (es) | 1978-02-15 |
ES435949A1 (es) | 1976-12-16 |
DE2513157A1 (de) | 1975-10-09 |
GB1498903A (en) | 1978-01-25 |
US4008323A (en) | 1977-02-15 |
CH596130A5 (es) | 1978-02-28 |
DE2513157C2 (es) | 1987-12-10 |
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