ES487012A1 - Procedimiento mejorado para la preparacion de 4-metil-2-ami-nobenzotiazol - Google Patents

Procedimiento mejorado para la preparacion de 4-metil-2-ami-nobenzotiazol

Info

Publication number
ES487012A1
ES487012A1 ES487012A ES487012A ES487012A1 ES 487012 A1 ES487012 A1 ES 487012A1 ES 487012 A ES487012 A ES 487012A ES 487012 A ES487012 A ES 487012A ES 487012 A1 ES487012 A1 ES 487012A1
Authority
ES
Spain
Prior art keywords
amino
benzothiazole
methyl
preparation
ring
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES487012A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Lonza AG
Original Assignee
Lonza AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lonza AG filed Critical Lonza AG
Publication of ES487012A1 publication Critical patent/ES487012A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D277/82—Nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Thiazole And Isothizaole Compounds (AREA)

Abstract

Procedimiento mejorado para la preparación de 4- metil-2-aminobenzotiazol, a partir de orto- totiltioruea con cloro como reactivo de cierre del anillo, caracterizado porque la otro- toliltiourea se suspende, en una dilución de 3 a 40 veces , en cloruro de metileno y se hace reaccionar a temperaturas de entre -20ºC y +15ª ce introduciendo de 1 a 2 moles de cloro por mol de ortor-toliltiourea, en ausencia de un catalizador, para formar el clorhidrato de 4-metil - 2-aminobenzotiazol y el clorhidrato en agua se transforma con un álcali en el 4-meti-2- aminobenzotiazo.
ES487012A 1978-12-20 1979-12-18 Procedimiento mejorado para la preparacion de 4-metil-2-ami-nobenzotiazol Expired ES487012A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH1293178A CH636865A5 (de) 1978-12-20 1978-12-20 Verfahren zur herstellung von 4-methyl-2-aminobenzthiazol.

Publications (1)

Publication Number Publication Date
ES487012A1 true ES487012A1 (es) 1980-10-01

Family

ID=4387727

Family Applications (1)

Application Number Title Priority Date Filing Date
ES487012A Expired ES487012A1 (es) 1978-12-20 1979-12-18 Procedimiento mejorado para la preparacion de 4-metil-2-ami-nobenzotiazol

Country Status (7)

Country Link
US (1) US4435576A (es)
EP (1) EP0013007B1 (es)
JP (1) JPS5583769A (es)
CA (1) CA1127650A (es)
CH (1) CH636865A5 (es)
DE (1) DE2962108D1 (es)
ES (1) ES487012A1 (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102532056B (zh) * 2011-12-26 2014-06-25 四川省化学工业研究设计院 取代苯并噻唑类化合物或其盐酸盐的制备方法
CN102731353A (zh) * 2012-07-07 2012-10-17 盛世泰科生物医药技术(苏州)有限公司 一种2-氨基-3-甲基苯硫酚的合成方法
CN103833673A (zh) * 2012-11-23 2014-06-04 中国中化股份有限公司 一种制备4-甲基-2-氨基苯并噻唑的方法
CN108558790B (zh) * 2018-05-28 2020-05-12 浙江禾本科技股份有限公司 一种2-氨基-4-甲基苯并噻唑的制备方法
CN111333593B (zh) * 2020-04-22 2022-04-29 湖北可赛化工有限公司 一种合成4-甲基-2肼基苯并噻唑的方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR688867A (fr) * 1929-01-26 1930-08-29 Ig Farbenindustrie Ag Procédé de production de systèmes cycliques sulfureux
US1911084A (en) * 1929-05-15 1933-05-23 Du Pont Process of manufacturing amino-aryl-thioglycollic intermediates
FR727410A (fr) * 1930-05-27 1932-06-17 Du Pont Nouveaux composés du groupe des thiazols et leur procédé de fabrication
CH592644A5 (es) * 1975-01-22 1977-10-31 Lonza Ag
DE2631163B2 (de) * 1976-07-10 1978-06-29 Basf Ag, 6700 Ludwigshafen Verfahren zur Herstellung von 2-Iminobenzothiazolen

Also Published As

Publication number Publication date
CA1127650A (en) 1982-07-13
DE2962108D1 (en) 1982-03-18
EP0013007A1 (de) 1980-07-09
JPS5583769A (en) 1980-06-24
EP0013007B1 (de) 1982-02-10
CH636865A5 (de) 1983-06-30
US4435576A (en) 1984-03-06

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