ES482240A1 - Procedimiento de obtencion de un complejo de platinoamina. - Google Patents
Procedimiento de obtencion de un complejo de platinoamina.Info
- Publication number
- ES482240A1 ES482240A1 ES482240A ES482240A ES482240A1 ES 482240 A1 ES482240 A1 ES 482240A1 ES 482240 A ES482240 A ES 482240A ES 482240 A ES482240 A ES 482240A ES 482240 A1 ES482240 A1 ES 482240A1
- Authority
- ES
- Spain
- Prior art keywords
- platinum
- group
- diamine
- carbon atoms
- mice
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 241000699670 Mus sp. Species 0.000 title 1
- 201000011510 cancer Diseases 0.000 title 1
- 239000003814 drug Substances 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 6
- 239000000460 chlorine Substances 0.000 abstract 4
- 229910052801 chlorine Inorganic materials 0.000 abstract 4
- 229910052739 hydrogen Inorganic materials 0.000 abstract 4
- 239000001257 hydrogen Substances 0.000 abstract 4
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 125000001309 chloro group Chemical group Cl* 0.000 abstract 3
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 3
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 2
- 150000002431 hydrogen Chemical class 0.000 abstract 2
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- OFOBLEOULBTSOW-UHFFFAOYSA-L Malonate Chemical compound [O-]C(=O)CC([O-])=O OFOBLEOULBTSOW-UHFFFAOYSA-L 0.000 abstract 1
- 125000000129 anionic group Chemical group 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
- C07F15/0006—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table compounds of the platinum group
- C07F15/0086—Platinum compounds
- C07F15/0093—Platinum compounds without a metal-carbon linkage
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Procedimiento de obtención de un complejo de platino-amina, en particular de obtención de un complejo de 1,3-alcanodiamina-platino (II) 2,2- sustituido, de fórmula (I) **(Fórmula-01)** en la que R1 y R2 independientemente pueden ser un átomo de hidrógeno o un grupo alquilo, cicloalquilo, arilo o aralquilo, sustituido o insustituido, mientras R1 y R2 pueden formar conjuntamente un grupo cicloalquillo sustituido o insustituido, R3 y R4 independientemente representan un átomo de hidrógeno o un grupo alquilo, arilo o aralquilo, sustituido o insustituido, y X representa un grupo aniónico; caracterizado porque comprende añadir una solución de K2PtC14 al hidrocloruro de **(Fórmula-02)** hervir la mezcla; y añadir una solución de NaOH en agua hasta que el pH de la solución permanece en 6; y, si se desea, convertir X en otro anión mediante reacción de un compuesto de fórmula (I) en donde R1, R2, R3 y R4 se definen como anteriormente y X es yodo, con nitrato de plata, en un medio acuoso; separar el yoduro de plata formado; y reaccionar entonces con una solución acuosa de KX, en donde X es el anión deseado.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
NL7807334A NL7807334A (nl) | 1978-07-06 | 1978-07-06 | Platina-diaminecomplexen, werkwijze voor het bereiden daarvan, werkwijze voor het bereiden van een genees- middel met toepassing van een dergelijk platina-dia- minecomplex voor de behandeling van kanker, alsmede al- dus verkregen gevormd geneesmiddel. |
Publications (1)
Publication Number | Publication Date |
---|---|
ES482240A1 true ES482240A1 (es) | 1980-10-01 |
Family
ID=19831207
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES482240A Expired ES482240A1 (es) | 1978-07-06 | 1979-07-05 | Procedimiento de obtencion de un complejo de platinoamina. |
ES490630A Expired ES8101080A1 (es) | 1978-07-06 | 1980-04-16 | Procedimiento de obtencion de un complejo de platino-amina |
ES490629A Granted ES490629A0 (es) | 1978-07-06 | 1980-04-16 | Procedimiento de obtencion de un complejo de platino-amina |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES490630A Expired ES8101080A1 (es) | 1978-07-06 | 1980-04-16 | Procedimiento de obtencion de un complejo de platino-amina |
ES490629A Granted ES490629A0 (es) | 1978-07-06 | 1980-04-16 | Procedimiento de obtencion de un complejo de platino-amina |
Country Status (36)
Country | Link |
---|---|
US (1) | US4410544A (es) |
JP (1) | JPS5513280A (es) |
AR (1) | AR226709A1 (es) |
AT (1) | AT377251B (es) |
AU (1) | AU533539B2 (es) |
BE (1) | BE877527A (es) |
CA (1) | CA1152088A (es) |
CH (2) | CH641758A5 (es) |
CS (1) | CS235301B2 (es) |
CY (1) | CY1320A (es) |
DD (1) | DD144780A5 (es) |
DE (1) | DE2927056A1 (es) |
DK (1) | DK153540C (es) |
ES (3) | ES482240A1 (es) |
FI (1) | FI76350C (es) |
FR (2) | FR2430406A1 (es) |
GB (1) | GB2024823B (es) |
GR (1) | GR69248B (es) |
HK (1) | HK9986A (es) |
HU (1) | HU183014B (es) |
IE (1) | IE48519B1 (es) |
IL (1) | IL57717A (es) |
IT (1) | IT1122011B (es) |
KE (1) | KE3590A (es) |
LU (1) | LU81470A1 (es) |
MY (1) | MY8600400A (es) |
NL (1) | NL7807334A (es) |
NO (1) | NO163898C (es) |
NZ (1) | NZ190923A (es) |
PH (1) | PH21386A (es) |
PT (1) | PT69877A (es) |
SE (1) | SE7905927L (es) |
SG (1) | SG91685G (es) |
SU (2) | SU1160937A3 (es) |
YU (1) | YU41652B (es) |
ZA (1) | ZA793394B (es) |
Families Citing this family (40)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NL8204067A (nl) * | 1982-10-21 | 1984-05-16 | Tno | Platina-diaminecomplexen, werkwijze voor het bereiden daarvan, werkwijze voor het bereiden van een geneesmiddel met toepassing van een dergelijk platinadiaminecomplex voor de behandeling van kanker, alsmede aldus verkregen gevormd geneesmiddel. |
JPS56154493A (en) * | 1980-04-30 | 1981-11-30 | Shionogi & Co Ltd | Novel platinum complex |
AU538863B2 (en) * | 1980-05-27 | 1984-08-30 | Bristol-Myers Company | Platinum complex salts have anti-tumor property |
JPS5716895A (en) * | 1980-07-05 | 1982-01-28 | Otsuka Chem Co Ltd | Platinum 2 complex and antitumor agent containing the same as active principle |
NL8101026A (nl) * | 1981-03-03 | 1982-10-01 | Tno | Platinadiamine-complexen, werkwijze voor het bereiden daarvan, werkwijze voor het bereiden van een geneesmiddel met toepassing van een dergelijk platinadiamine-complex voor de behandeling van kanker alsmede aldus verkregen gevormd geneesmiddel. |
JPS57156416A (en) * | 1981-03-24 | 1982-09-27 | Otsuka Chem Co Ltd | Platinum (2) complex and antitumor agent comprising it as active ingredient |
US4786725A (en) * | 1982-06-28 | 1988-11-22 | Engelhard Corporation | Solubilized platinum (II) complexes |
DE3305248C2 (de) * | 1983-02-16 | 1987-04-09 | Degussa Ag, 6000 Frankfurt | Verfahren zur Reinigung von cis-Platin-(II)-diammin-dichlorid |
US4598091A (en) * | 1983-02-18 | 1986-07-01 | Degussa Aktiengesellschaft | (1,2-diphenyl)-ethylenediamine)-platinum (II) complex compounds |
ZA843515B (en) * | 1983-05-10 | 1985-01-30 | Andrulis Res Corp | Bis-platinum complexes as antitumor agents |
US4565884A (en) * | 1983-05-10 | 1986-01-21 | Andrulis Research Corporation | Bis-platinum complexes as antitumor agents |
US4720504A (en) * | 1983-05-10 | 1988-01-19 | Andrulis Research Corporation | Use of bis-platinum complexes as antitumor agents |
US4758588A (en) * | 1983-06-20 | 1988-07-19 | Research Corporation Technologies | Diaminocyclohexane platinum complexes |
US4661516A (en) * | 1983-06-20 | 1987-04-28 | Research Corporation | Diaminocyclohexane platinum complexes |
US4562275A (en) * | 1984-03-23 | 1985-12-31 | Bristol-Myers Co. | Antitumor platinum complexes |
US4952676A (en) * | 1984-06-27 | 1990-08-28 | Johnson Matthey Plc | Monoclonal antibody-platinum co-ordination compound complex |
EP0169645A1 (en) * | 1984-06-27 | 1986-01-29 | Johnson Matthey Public Limited Company | Platinum co-ordination compounds |
DE3432320A1 (de) * | 1984-09-03 | 1986-03-13 | Behringwerke Ag, 3550 Marburg | Cis-platin-komplexe mit einem pentaerythritderivat als liganden, verfahren zu ihrer herstellung und diese verbindungen enthaltendes pharmazeutisches mittel |
HU193809B (en) * | 1984-09-12 | 1987-12-28 | Chugai Pharmaceutical Co Ltd | Process for producing new platinum complexes |
US4665210A (en) * | 1984-12-17 | 1987-05-12 | American Cyanamid Company | Platinum complexes of aliphatic tricarboxylic acids |
US4739087A (en) * | 1985-01-10 | 1988-04-19 | Bristol-Myers Company | Antineoplastic platinum complexes |
US4567285A (en) * | 1985-07-10 | 1986-01-28 | Yoshinori Kidani | Complex compounds of platinum |
JPS6345290A (ja) * | 1985-08-27 | 1988-02-26 | Nippon Kayaku Co Ltd | 新規白金錯体 |
US4737589A (en) * | 1985-08-27 | 1988-04-12 | Nippon Kayaku Kabushiki Kaisha | Platinum Complexes |
US5116831A (en) * | 1985-12-24 | 1992-05-26 | Warner-Lambert Company | Aminoalkyl-substituted cycloalkylamine platinum (II) complexes |
US4970324A (en) * | 1985-12-24 | 1990-11-13 | Hoeschele James D | Aminoalkyl-substituted azetidine platinum(II) complexes |
US4880790A (en) * | 1986-01-31 | 1989-11-14 | American Cyanamid Company | (Gem-heterocyclodimethanamine-N,N')platinum complexes |
US4760157A (en) * | 1986-01-31 | 1988-07-26 | American Cyanamid Company | (2,2,-bis(aminomethyl)-1,3-propanediol-N,N')platinum complexes |
US4716157A (en) * | 1986-03-20 | 1987-12-29 | American Cyanamid Company | Heterocyclic-1,2-diamine platinum complexes |
JPH05345792A (ja) * | 1986-07-01 | 1993-12-27 | Nippon Kayaku Co Ltd | 新規白金錯体 |
DE3630497A1 (de) * | 1986-09-08 | 1988-03-10 | Behringwerke Ag | Cis-platin-komplexe, verfahren zu ihrer herstellung und diese verbindungen enthaltende pharmazeutische mittel |
JPS63203692A (ja) * | 1987-02-19 | 1988-08-23 | Nippon Kayaku Co Ltd | 新規白金錯体 |
US4870070A (en) * | 1987-08-10 | 1989-09-26 | American Cyanamid Company | Water soluble platinum complexes of novel malonate derivatives |
AT390065B (de) * | 1987-10-08 | 1990-03-12 | Behringwerke Ag | Cis-platin-komplexe, verfahren zu ihrer herstellung und diese verbindungen enthaltende pharmazeutische mittel |
ES2054778T3 (es) * | 1988-01-09 | 1994-08-16 | Asta Medica Ag | Complejos de 1,2-bis (aminometil) ciclobutano-platino. |
NL8802150A (nl) * | 1988-08-31 | 1990-03-16 | Tno | Platina-(ii)-diaminecomplex, werkwijze voor het bereiden van deze verbinding, preparaat met anti-tumor werking, dat deze verbinding bevat, alsmede gevormde preparaten met anti-tumor werking. |
NL8802149A (nl) * | 1988-08-31 | 1990-03-16 | Tno | Platina-(iv)diaminecomplex, werkwijze voor het bereiden van deze verbinding, preparaat met anti-tumor werking, dat ten minste een platinaverbinding bevat, alsmede gevormde preparaten met anti-tumor werking. |
US4895960A (en) * | 1989-01-23 | 1990-01-23 | University Of Cincinnati | Cyclo substituted propyleneamine oxime and its use as a brain imaging agent |
JPH0776230B2 (ja) * | 1992-01-13 | 1995-08-16 | 田中貴金属工業株式会社 | 白金化合物の製造方法 |
DE4415263C1 (de) * | 1994-04-15 | 1995-11-30 | Asta Medica Ag | Cis-[trans-1,2-Cyclobutanbis(methylamin)-N,N']-[(2S)-lactato-O·1·, O·2·]-platin(II)-trihydrat (Lobaplatin-Trihydrat), seine Herstellung und arzneiliche Verwendung |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1432563A (en) * | 1972-04-10 | 1976-04-22 | Rustenburg Platinum Mines Ltd | Platinum- co-ordination compounds |
GB1432562A (en) * | 1972-04-10 | 1976-04-22 | Rustenburg Platinum Mines Ltd | Platinum co-ordination compounds |
CH605550A5 (es) * | 1972-06-08 | 1978-09-29 | Research Corp | |
JPS5829957B2 (ja) * | 1977-09-12 | 1983-06-25 | 喜徳 喜谷 | 新規な白金錯体 |
-
1978
- 1978-07-06 NL NL7807334A patent/NL7807334A/xx not_active Application Discontinuation
-
1979
- 1979-07-03 GB GB7923073A patent/GB2024823B/en not_active Expired
- 1979-07-03 CY CY1320A patent/CY1320A/xx unknown
- 1979-07-04 IL IL57717A patent/IL57717A/xx not_active IP Right Cessation
- 1979-07-04 DE DE19792927056 patent/DE2927056A1/de active Granted
- 1979-07-04 HU HU79NE613A patent/HU183014B/hu not_active IP Right Cessation
- 1979-07-04 IT IT24099/79A patent/IT1122011B/it active
- 1979-07-05 NZ NZ190923A patent/NZ190923A/xx unknown
- 1979-07-05 CA CA000331212A patent/CA1152088A/en not_active Expired
- 1979-07-05 FR FR7917524A patent/FR2430406A1/fr active Granted
- 1979-07-05 NO NO792240A patent/NO163898C/no unknown
- 1979-07-05 LU LU81470A patent/LU81470A1/fr unknown
- 1979-07-05 AU AU48679/79A patent/AU533539B2/en not_active Ceased
- 1979-07-05 GR GR59517A patent/GR69248B/el unknown
- 1979-07-05 FI FI792127A patent/FI76350C/fi not_active IP Right Cessation
- 1979-07-05 CS CS794751A patent/CS235301B2/cs unknown
- 1979-07-05 DK DK284979A patent/DK153540C/da not_active IP Right Cessation
- 1979-07-05 ES ES482240A patent/ES482240A1/es not_active Expired
- 1979-07-05 AT AT0469079A patent/AT377251B/de not_active IP Right Cessation
- 1979-07-05 JP JP8448979A patent/JPS5513280A/ja active Granted
- 1979-07-05 PT PT69877A patent/PT69877A/pt not_active IP Right Cessation
- 1979-07-06 CH CH636579A patent/CH641758A5/de not_active IP Right Cessation
- 1979-07-06 YU YU1662/79A patent/YU41652B/xx unknown
- 1979-07-06 SE SE7905927A patent/SE7905927L/ unknown
- 1979-07-06 ZA ZA793394A patent/ZA793394B/xx unknown
- 1979-07-06 CH CH5787/83A patent/CH649525A5/de not_active IP Right Cessation
- 1979-07-06 SU SU792788104A patent/SU1160937A3/ru active
- 1979-07-06 BE BE0/196165A patent/BE877527A/nl not_active IP Right Cessation
- 1979-07-06 DD DD79214180A patent/DD144780A5/de unknown
- 1979-08-08 IE IE1271/79A patent/IE48519B1/en not_active IP Right Cessation
-
1980
- 1980-04-16 ES ES490630A patent/ES8101080A1/es not_active Expired
- 1980-04-16 ES ES490629A patent/ES490629A0/es active Granted
- 1980-11-24 AR AR283341A patent/AR226709A1/es active
-
1981
- 1981-07-27 US US06/287,531 patent/US4410544A/en not_active Expired - Fee Related
- 1981-08-04 PH PH26006A patent/PH21386A/en unknown
-
1982
- 1982-09-14 FR FR8215536A patent/FR2511685B1/fr not_active Expired
-
1983
- 1983-05-04 SU SU833585700A patent/SU1414850A1/ru active
-
1985
- 1985-12-02 SG SG916/85A patent/SG91685G/en unknown
- 1985-12-06 KE KE3590A patent/KE3590A/xx unknown
-
1986
- 1986-02-05 HK HK99/86A patent/HK9986A/xx unknown
- 1986-12-30 MY MY400/86A patent/MY8600400A/xx unknown
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD1A | Patent lapsed |
Effective date: 19970303 |