ES481714A1 - Procedimiento para la obtencion de derivados de tetrahidro- piridina y piperidina. - Google Patents

Procedimiento para la obtencion de derivados de tetrahidro- piridina y piperidina.

Info

Publication number
ES481714A1
ES481714A1 ES481714A ES481714A ES481714A1 ES 481714 A1 ES481714 A1 ES 481714A1 ES 481714 A ES481714 A ES 481714A ES 481714 A ES481714 A ES 481714A ES 481714 A1 ES481714 A1 ES 481714A1
Authority
ES
Spain
Prior art keywords
lower alkyl
rats
acid addition
addition salts
brain
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES481714A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Ciba Geigy AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy AG filed Critical Ciba Geigy AG
Publication of ES481714A1 publication Critical patent/ES481714A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, ***e
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/86—Benzo [b] furans; Hydrogenated benzo [b] furans with an oxygen atom directly attached in position 7
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/91—Dibenzofurans; Hydrogenated dibenzofurans

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

1. Procedimiento para la obtención de derivados de tetrahidropiridina y piperidina de fórmula general I **Fórmula 01** donde R1 y R2 independientes entre sí, significan hidrógeno o alquilo inferior o juntos significan alquileno inferior; R3 significa hidrógeno, alquilo inferior, alquenilo inferior, alquinilo inferior, cicloalquilo o cicloalquil-alquilo inferior e Y1 e Y2 cada uno significa hidrógeno o juntos un enlace adicional, y el anillo A no está ulteriormente sustituido ó está ulteriormente sustituido y sus sales de adición de ácido, caracterizado porque en un compuesto de fórmula general II **Fórmula 02** donde Ra4 significa un resto 1,2,3,6-tetrahidro-4-piridilo o 4-piperidilo, que en caso dado está sustituido en como mínimo uno de los átomos de carbono de anillo adyacentes al átomo de nitrógeno por un resto Xa divalente sustituible por 2 átomos de hidrógeno, y en cuyo átomo de nitrógeno está enlazado un resto R3 según la definición, que en caso dado está sustituido en su posición 1,por un resto Xa, según la definición, o un átomo de carbono que lleva un resto Xa, según la definición y alcoxi inferior, debiendo estar presente en total como mínimo un resto Xa, según la definición, R1 y R2 tienen el significado indicado bajo la fórmula I y el anillo A no está ulteriormente sustituido o ulteriormente sustituido, el o los restos Xa y, en caso de estar presente, el alcoxi inferior antes mencionado, se sustituye por hidrógeno y en caso deseado se separa una mezcla de isómeros (mezcla de racematos) en los isómeros (racematos) puros y/o un racemato obtenido se disocia en los antípodas ópticos y/o un compuesto libre obtenible se transforma en una sal, obtenida en el compuesto libre o en otra sal.
ES481714A 1978-06-22 1979-06-20 Procedimiento para la obtencion de derivados de tetrahidro- piridina y piperidina. Expired ES481714A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH682378 1978-06-22

Publications (1)

Publication Number Publication Date
ES481714A1 true ES481714A1 (es) 1980-06-16

Family

ID=4315581

Family Applications (3)

Application Number Title Priority Date Filing Date
ES481714A Expired ES481714A1 (es) 1978-06-22 1979-06-20 Procedimiento para la obtencion de derivados de tetrahidro- piridina y piperidina.
ES489628A Expired ES8104281A1 (es) 1978-06-22 1980-03-17 Procedimiento para la obtencion de derivados de tetrahidro- piridina y piperidina
ES489627A Expired ES8104280A1 (es) 1978-06-22 1980-03-17 Procedimiento para la obtencion de derivados de tetrahidro- piridina y piperidina

Family Applications After (2)

Application Number Title Priority Date Filing Date
ES489628A Expired ES8104281A1 (es) 1978-06-22 1980-03-17 Procedimiento para la obtencion de derivados de tetrahidro- piridina y piperidina
ES489627A Expired ES8104280A1 (es) 1978-06-22 1980-03-17 Procedimiento para la obtencion de derivados de tetrahidro- piridina y piperidina

Country Status (10)

Country Link
US (1) US4259338A (es)
EP (1) EP0006524A1 (es)
JP (1) JPS552697A (es)
AU (1) AU523656B2 (es)
CA (1) CA1119601A (es)
DD (1) DD144545A5 (es)
DK (1) DK259879A (es)
ES (3) ES481714A1 (es)
NZ (1) NZ190784A (es)
ZA (1) ZA793091B (es)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4490531A (en) * 1981-07-01 1984-12-25 The Upjohn Company Pyridyl-substituted-benzofurans
US4495357A (en) * 1981-07-01 1985-01-22 The Upjohn Company Pyridyl-substituted-benzofurans
US4455427A (en) * 1981-07-01 1984-06-19 The Upjohn Company Pyridyl-substituted-benzofurans
US4447620A (en) * 1982-06-08 1984-05-08 The Upjohn Company Imidazolyl-substituted benzothiophenes
US4452986A (en) * 1982-06-08 1984-06-05 The Upjohn Company Imidazolyl-substituted benzofurans
DD212962A5 (de) * 1982-10-08 1984-08-29 Ciba Geigy Ag Verfahren zur herstellung von benzofuranen
US4855435A (en) * 1982-10-12 1989-08-08 The Upjohn Company Pyridyl-substituted benzothiophenes
US4611059A (en) * 1982-10-12 1986-09-09 The Upjohn Company Pyridyl-substituted benzothiophenes
EP0398413A1 (en) * 1989-05-16 1990-11-22 Duphar International Research B.V "3,4-dehydropiperidine derivatives having psychotropic activity
US5296497A (en) * 1989-05-16 1994-03-22 Duphar International Research B.V. 3,4-dehydropiperidine derivatives having psychotropic activity
US5068359A (en) * 1989-06-20 1991-11-26 Ciba-Geigy Corporation Microbicidal compositions
DE4017211A1 (de) * 1990-05-29 1991-12-05 Merck Patent Gmbh Oxazolidinone
TW222631B (es) * 1991-07-15 1994-04-21 Duphar Int Res
DE69418789T2 (de) * 1993-08-05 1999-12-02 Hoechst Marion Roussel Inc 2-(Piperidin-4-yl, Pyridin-4-yl und Tetrahydropyridin-4-yl)-benzofuran-7-carbamat Derivate, ihre Herstellung und Verwendung als Acetylcholinesterase Inhibitoren
JPH07320652A (ja) * 1994-05-27 1995-12-08 Toshiba Corp カラー受像管及びシャドウマスクの製造方法
AU7135996A (en) * 1995-10-11 1997-04-30 Synthelabo Oxazolidin-2-one derivatives, preparation method therefor and therapeutical use thereof
FR2739856B1 (fr) * 1995-10-11 1997-11-14 Synthelabo Derives de 3-benzofuranyloxazolidin-2-one, leur procede de preparation et leur application en therapeutique
FR2751653B1 (fr) * 1996-07-25 1998-09-04 Synthelabo Derives de 3-benzofuranyloxazolidin-2-one, leur procede de preparation et leur application en therapeutique
FR2741072B1 (fr) * 1995-11-09 1997-12-12 Synthelabo Derives d'oxazolidin-2-one, leur preparation et leur application en therapeutique
FR2741071B1 (fr) * 1995-11-09 1997-12-12 Synthelabo Derives de 3-(benzofuran-5-yl)oxazolidin-2-one, leur preparation et leur application en therapeutique
CO5080791A1 (es) * 1998-06-30 2001-09-25 Lilly Co Eli Derivados de la piperidina que tienen efectos sobre sistemas con serotonina
ES2203498T3 (es) * 1999-07-29 2004-04-16 Eli Lilly And Company Benzofurilpiperazinas: agonistas de receptor 5-ht2c de la serotonina.
DE60002583T2 (de) * 1999-07-29 2004-03-25 Eli Lilly And Co., Indianapolis Benzofurylpiperazine als serotonin-agonisten
US6881733B1 (en) 1999-07-29 2005-04-19 Eli Lilly And Company Serotonergic benzofurans
JP2003506369A (ja) * 1999-07-29 2003-02-18 イーライ・リリー・アンド・カンパニー セロトニン作動性のベンゾフラン
JP2005008631A (ja) * 2003-05-29 2005-01-13 New Industry Research Organization ベンゾフラン化合物、およびそれを含有してなる医薬組成物
WO2004106317A1 (ja) * 2003-05-29 2004-12-09 The New Industry Research Organization ベンゾフラン化合物、およびそれを含有してなる医薬組成物
EP2110374A1 (en) * 2008-04-18 2009-10-21 Merck Sante Benzofurane, benzothiophene, benzothiazol derivatives as FXR modulators
CN101810606A (zh) * 2010-03-12 2010-08-25 南方医科大学 2-(6-羟基-2′,3′-二甲氧基苯基)-6-羟基-7-甲氧基苯骈呋喃在制备单胺氧化酶抑制剂中的应用
CN102381961B (zh) * 2011-09-03 2014-01-15 四川大学 3-苯基戊二酸类化合物、其制备方法和用途

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2633468A (en) * 1951-07-26 1953-03-31 Lilly Co Eli Benzooxaheterocyclic bases and acid addition salts thereof
GB1041525A (en) * 1964-11-11 1966-09-07 Belge Produits Chimiques Sa Benzofuran derivatives and processes for preparing the same
US3751390A (en) * 1971-05-19 1973-08-07 Aldrich Chem Co Inc Substituted dibenzofuran
BE794630A (fr) * 1972-01-26 1973-07-26 Beecham Group Ltd Composes polycycliques antihypertenseurs
CH592656A5 (es) * 1973-03-02 1977-10-31 Ciba Geigy Ag
IE39264B1 (en) * 1973-05-25 1978-08-30 Ciba Geigy Ag New pharmaceutical preparations
CH609054A5 (en) * 1975-11-26 1979-02-15 Ciba Geigy Ag Process for the preparation of a novel piperidine derivative
CH605925A5 (es) * 1974-08-30 1978-10-13 Ciba Geigy Ag
LU76756A1 (es) * 1977-02-11 1978-10-18

Also Published As

Publication number Publication date
ES489628A0 (es) 1981-04-01
ES489627A0 (es) 1981-04-01
AU4825779A (en) 1980-01-03
ZA793091B (en) 1980-06-25
EP0006524A1 (de) 1980-01-09
ES8104281A1 (es) 1981-04-01
CA1119601A (en) 1982-03-09
DK259879A (da) 1979-12-23
ES8104280A1 (es) 1981-04-01
DD144545A5 (de) 1980-10-22
JPS552697A (en) 1980-01-10
AU523656B2 (en) 1982-08-05
US4259338A (en) 1981-03-31
NZ190784A (en) 1982-03-16

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