ES479410A1 - Un procedimiento para la preparacion de derivados del acido 4-tiazolidincarboxilico. - Google Patents

Un procedimiento para la preparacion de derivados del acido 4-tiazolidincarboxilico.

Info

Publication number
ES479410A1
ES479410A1 ES479410A ES479410A ES479410A1 ES 479410 A1 ES479410 A1 ES 479410A1 ES 479410 A ES479410 A ES 479410A ES 479410 A ES479410 A ES 479410A ES 479410 A1 ES479410 A1 ES 479410A1
Authority
ES
Spain
Prior art keywords
antihypertensive
pyridyl derivatives
thiazolidinecarboxylic
acids
thiazolidinecarboxylic acids
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES479410A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Santen Pharmaceutical Co Ltd
Original Assignee
Santen Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP4163278A external-priority patent/JPS54135768A/ja
Priority claimed from JP4965778A external-priority patent/JPS54148783A/ja
Priority claimed from JP8111678A external-priority patent/JPS557255A/ja
Application filed by Santen Pharmaceutical Co Ltd filed Critical Santen Pharmaceutical Co Ltd
Publication of ES479410A1 publication Critical patent/ES479410A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/04—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D277/06—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)

Abstract

Un procedimiento para la preparación de derivados del ácido 4-tiazolidincarboxilico de fórmula-01 (I): **(Fórmula-01)** donde R1 es mercaptoalquilo inferior, acilmercapto-alquilo inferior, alquilo superior, cicloalquilo, aralquilo, fenilo, furilo, tienilo, piridilo, naftilo, alquilo superior sustituido, cicloalquilo sustituido, aralquilo sustituido, fenilo sustituido, furilo sustituido, tienilo sustituido, piridilo sustituido o naftilo sustituido, donde el o los sustituyentes son alquilo inferior, hidroxi, mercapto, alcoxi inferior, alquilendioxi inferior, aciloxi, acilmercapto, halógeno, nitro, amino, alquilamino inferior, acilamino o carboxi; R2 es hidrógeno o benzoilo; A es alquileno lineal o ramificado de 1 a 3 átomos de carbono; y sales del mismo, cuyo procedimiento comprende: a) hacer reaccionar un ácido de fórmula-02 (II): **(Fórmula-02)** donde R3 es acilmercapto alquilo inferior, alquilo superior, cicloalquilo, aralquilo, fenilo, furilo, tienilo, piridilo, naftilo, alquilo superiorsustituido, cicloalquilo sustituido, aralquilo sustituido, fenilo sustituido, furilo sustituido, tienilo sustituido, piridilo sustituido o naftilo sustituido, donde el o los sustituyentes son alquilo inferior, hidroxi, alcoxi inferior, alquilendioxi inferior, aciloxi, acilmercapto, halógeno, nitro, alquilamino inferior, acilamino o carboxi, con un compuesto de fórmula: Z - A - CO - Y, donde A es alquileno lineal o ramificado de 1 a 3 átomos de carbono e Y es hidroxi o halógeno, Z es R4 - S - o halógeno, y R4 es benzoilo o bencilo; b) cuando Z es halógeno, hacer reaccionar el producto obtenido en la etapa anterior con un compuesto de fórmula: M - SH, donde M es bencilo o benzoilo; y c) opcionalmente hidrolizar o reducir los compuestos obtenidos.
ES479410A 1978-04-08 1979-04-06 Un procedimiento para la preparacion de derivados del acido 4-tiazolidincarboxilico. Expired ES479410A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP4163278A JPS54135768A (en) 1978-04-08 1978-04-08 Thiazolidine derivative
JP4965778A JPS54148783A (en) 1978-04-25 1978-04-25 Thiazolidine derivative
JP8111678A JPS557255A (en) 1978-07-03 1978-07-03 Thiazolidine derivative

Publications (1)

Publication Number Publication Date
ES479410A1 true ES479410A1 (es) 1980-08-16

Family

ID=27290900

Family Applications (1)

Application Number Title Priority Date Filing Date
ES479410A Expired ES479410A1 (es) 1978-04-08 1979-04-06 Un procedimiento para la preparacion de derivados del acido 4-tiazolidincarboxilico.

Country Status (11)

Country Link
US (5) US4430344A (es)
AU (1) AU528115B2 (es)
CA (1) CA1127157A (es)
CH (1) CH649293A5 (es)
DE (1) DE2914059C2 (es)
ES (1) ES479410A1 (es)
FR (1) FR2421889A1 (es)
GB (1) GB2018248B (es)
IT (1) IT1115158B (es)
NL (1) NL7902710A (es)
SE (1) SE434943B (es)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA794723B (en) * 1978-09-11 1980-08-27 Univ Miami Anti-hypertensive agents
US4483861A (en) * 1978-10-31 1984-11-20 Santen Pharmaceutical Co., Ltd. Antihypertensive sulfur-containing compounds
JPS56139455A (en) * 1980-04-02 1981-10-30 Santen Pharmaceut Co Ltd Sulfur-containing acylaminoacid
JPS5756425A (en) * 1980-09-20 1982-04-05 Santen Pharmaceut Co Ltd Hypotensor
DE3152643A1 (de) * 1980-12-29 1982-12-16 Santen Pharmaceutical Co Ltd Heterocyclic 5-membered ring compounds
JPS57112381A (en) * 1980-12-29 1982-07-13 Santen Pharmaceut Co Ltd Five-membered heterocyclic compound
JPS57142962A (en) * 1981-02-28 1982-09-03 Santen Pharmaceut Co Ltd Cyclodextrin clathrate compound of sulfur-containing compound
DE3134933A1 (de) * 1981-09-03 1983-03-31 Hoechst Ag, 6230 Frankfurt "harnstoffderivate, verfahren zu ihrer herstellung und diese enthaltende medikamente sowie deren verwendung"
IT1153963B (it) * 1982-03-22 1987-01-21 Montedison Spa Derivati dell'acido 2 0 4-tiazolidin-carbossilico 3-acil sostituiti ad azione fitoregolatrice e biostimolanti
IT1191109B (it) * 1982-12-03 1988-02-24 Simes Derivati di acidi aminopiridincarbossilici,loro metodo di sintesi e composizioni farmaceutiche che li contengono
US4631343A (en) * 1983-11-07 1986-12-23 Eli Lilly And Company Cyanopyrazole intermediates
GB2164333B (en) * 1984-07-27 1988-11-16 Boehringer Biochemia Srl Antitussive and mucus regulating 2-substituted thiazolidines
IT1196485B (it) * 1986-07-14 1988-11-16 Zambon Spa Derivati dell'acido tiazolidin-4-carbossilico ad attivita' farmaceutica
CN1030415A (zh) * 1987-02-20 1989-01-18 山之内制药株式会社 饱和的杂环碳酰胺衍生物和它的制备方法
IT1241415B (it) * 1990-03-05 1994-01-14 Yason Srl Derivato dell'acido s-(2-tenoil)-tiolattico ad attivita' farmacologica
CA2178130C (en) * 1995-06-05 2002-04-02 Hiroshi Ikawa Method of producing 2-naphthamide derivative, and compounds for producing 2-naphthamide derivative
US6083966A (en) 1998-08-31 2000-07-04 University Of Florida Thiazoline acid derivatives
NZ509172A (en) * 1998-09-21 2004-02-27 Univ Florida Antimalarial agents
US20040132789A1 (en) * 2002-08-22 2004-07-08 University Of Florida Antioxidant and radical scavenging activity of synthetic analogs of desferrithiocin
US20040044220A1 (en) * 2002-08-22 2004-03-04 University Of Florida Antioxidant and radical scavenging activity of synthetic analogs of desferrithiocin
US7687468B2 (en) * 2003-05-14 2010-03-30 Viacell, LLC. Rejuvenation of stored blood
WO2005034949A1 (en) * 2003-09-09 2005-04-21 University Of Florida Desferrithiocin derivatives and their use as iron chelators
DK1866296T3 (en) 2005-04-04 2017-02-13 Univ Florida DESFERRITHIOCINPOLYETHER-ANALOGS
BRPI0809077A2 (pt) * 2007-03-15 2014-09-09 Univ Florida Res Foudantion Inc Análogos de poliéter de desferritiocina
US20140343110A1 (en) 2011-12-16 2014-11-20 University Of Florida Research Foundation, Inc. Uses of 4'-desferrithiocin analogs
RU2526619C2 (ru) * 2012-12-12 2014-08-27 Федеральное государственное бюджетное учреждение науки Институт высокомолекулярных соединений Российской академии наук Способ получения (2r,4r)-2-алкил-3-(2-меркаптобензоил)-1,3-тиазолидин-4-карбоновых кислот
EP3071201A4 (en) 2013-11-22 2017-04-26 University of Florida Research Foundation, Inc. Desferrithiocin analogs and uses thereof
CA2984250A1 (en) 2015-04-27 2016-11-03 University Of Florida Research Foundation, Incorporated Metabolically programmed metal chelators and uses thereof

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3592905A (en) * 1969-10-30 1971-07-13 Merck & Co Inc Therapeutic methods
FR2356423A1 (fr) * 1976-07-01 1978-01-27 Oeriu Simion Derives de l'acide thiazolidinecarboxylique, leur preparation et leur application comme medicaments
US4192878A (en) 1976-12-03 1980-03-11 E. R. Squibb & Sons, Inc. Derivatives of thiazolidinecarboxylic acids and related acids
AU518147B2 (en) * 1976-12-03 1981-09-17 E.R. Squibb & Sons, Inc. Derivatives of thiazolidine, thiazine and morpholine carboxylic acids
FR2395998A1 (fr) 1977-06-29 1979-01-26 Yoshitomi Pharmaceutical Nouveaux derives de la thiazolidine et leur application dans le traitement de l'hypertension
JPS5834474B2 (ja) 1977-06-29 1983-07-27 ウェルファイド株式会社 チアゾリジン誘導体の製造法
JPS6047264B2 (ja) * 1977-08-15 1985-10-21 ウェルファイド株式会社 チアゾリジン誘導体
FR2404635A1 (fr) * 1977-09-28 1979-04-27 Science Union & Cie Nouveaux thioproprionylamides, leurs procedures d'obtention et leur emploi en therapeutique
US4282235A (en) * 1978-05-22 1981-08-04 E. R. Squibb & Sons, Inc. Derivatives of thiazolidinecarboxylic acids and related acids
US4347371A (en) * 1978-12-30 1982-08-31 Santen Pharmaceutical Co., Ltd. Disulfide compounds
US4374249A (en) * 1980-12-23 1983-02-15 American Cyanamid Company [4R]-3-(ω-Aroylpropionyl)-4-thiazolidinecarboxylic acids and esters

Also Published As

Publication number Publication date
GB2018248A (en) 1979-10-17
GB2018248B (en) 1982-10-27
IT1115158B (it) 1986-02-03
FR2421889A1 (fr) 1979-11-02
SE434943B (sv) 1984-08-27
US4423054A (en) 1983-12-27
DE2914059A1 (de) 1979-10-25
CH649293A5 (de) 1985-05-15
US4430344A (en) 1984-02-07
US4457935A (en) 1984-07-03
FR2421889B1 (es) 1982-11-19
SE7902910L (sv) 1979-10-09
DE2914059C2 (de) 1984-09-06
NL7902710A (nl) 1979-10-10
CA1127157A (en) 1982-07-06
US4356183A (en) 1982-10-26
US4386096A (en) 1983-05-31
IT7921666A0 (it) 1979-04-06
AU528115B2 (en) 1983-04-14
AU4544479A (en) 1979-10-18

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19971001