ES475359A1 - Procedimiento para preparar acido d,1-b-benzoilaminoisobuti-rico - Google Patents

Procedimiento para preparar acido d,1-b-benzoilaminoisobuti-rico

Info

Publication number
ES475359A1
ES475359A1 ES475359A ES475359A ES475359A1 ES 475359 A1 ES475359 A1 ES 475359A1 ES 475359 A ES475359 A ES 475359A ES 475359 A ES475359 A ES 475359A ES 475359 A1 ES475359 A1 ES 475359A1
Authority
ES
Spain
Prior art keywords
benzoylamino
beta
isobutyric acid
manufacturing
isobutyronitrile
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES475359A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sigma Tau Industrie Farmaceutiche Riunite SpA
Original Assignee
Sigma Tau Industrie Farmaceutiche Riunite SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sigma Tau Industrie Farmaceutiche Riunite SpA filed Critical Sigma Tau Industrie Farmaceutiche Riunite SpA
Publication of ES475359A1 publication Critical patent/ES475359A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00—Preparation of carboxylic acid nitriles
    • C07C253/30—Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

Procedimiento para preparar ácido d,1-beta-benzoilaminoisobutírico. La síntesis del ácido se efectúa en dos etapas, que se efectúan, ambas, a presión atmosférica. En la primera etapa, la benzamida se hace reaccionar directamente con metacrilonitrilo en presencia de un catalizador alcalino, en un medio disolvente anhidro, a la temperatura de reflujo de la mezcla (80-100ºC) y a presión atmosférica, obteniendo así, d-1-beta-benzoilaminoisobutironitrilo. En la segunda etapa, el d,1-beta-benzoilaminoisobutironitrilo obtenido en la etapa primera se somete directamente, tras simple lavado con un disolvente (siendo particularmente adecuado el éter metil-terc-butílico) para eliminar impurezas céreas.
ES475359A 1977-11-30 1978-11-24 Procedimiento para preparar acido d,1-b-benzoilaminoisobuti-rico Expired ES475359A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT52004/77A IT1116382B (it) 1977-11-30 1977-11-30 Metodo di preparazione industriale dell'acido rs-beta-benzoilamino isobutirrico

Publications (1)

Publication Number Publication Date
ES475359A1 true ES475359A1 (es) 1979-04-01

Family

ID=11276181

Family Applications (1)

Application Number Title Priority Date Filing Date
ES475359A Expired ES475359A1 (es) 1977-11-30 1978-11-24 Procedimiento para preparar acido d,1-b-benzoilaminoisobuti-rico

Country Status (20)

Country Link
US (1) US4335256A (es)
JP (1) JPS5484542A (es)
AT (1) AT362769B (es)
AU (1) AU520597B2 (es)
BE (1) BE872139A (es)
CA (1) CA1107757A (es)
CH (1) CH636850A5 (es)
DE (1) DE2851427A1 (es)
DK (1) DK149197C (es)
ES (1) ES475359A1 (es)
FR (1) FR2410643A1 (es)
GB (1) GB2009176B (es)
GR (1) GR65322B (es)
IE (1) IE47564B1 (es)
IT (1) IT1116382B (es)
LU (1) LU80602A1 (es)
NL (1) NL185076C (es)
NO (1) NO148885C (es)
PT (1) PT68816A (es)
SE (1) SE431448B (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USRE32952E (en) * 1986-05-19 1989-06-13 Minnesota Mining And Manufacturing Company Method of preparing N-acryloyl-α-amino acids
US4694103A (en) * 1986-05-19 1987-09-15 Minnesota Mining And Manufacturing Company Method of preparing N-acryloyl-α-amino acids
GB9520092D0 (en) * 1995-10-02 1995-12-06 Hoechst Roussel Ltd Chemical compounds

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2461842A (en) * 1943-02-26 1949-02-15 Sharples Chemicals Inc Condensation of nitriles with amides and the production of beta-alanine
US2510784A (en) * 1949-01-13 1950-06-06 Sterling Drug Inc Bis (tertiaryaminoalkyl) arylacetonitriles and the corresponding acids and esters
US2849477A (en) * 1956-06-12 1958-08-26 Dornow Alfred Preparation of alpha-acylamino-nitriles
US3489793A (en) * 1966-05-16 1970-01-13 Francia Formaceutici S R L New benzamido butyric acid derivatives

Also Published As

Publication number Publication date
DE2851427C2 (es) 1987-12-03
BE872139A (fr) 1979-03-16
NL185076C (nl) 1990-01-16
AT362769B (de) 1981-06-10
NO148885B (no) 1983-09-26
NL7811674A (nl) 1979-06-01
CA1107757A (en) 1981-08-25
NO784014L (no) 1979-05-31
GB2009176B (en) 1982-02-24
AU4167078A (en) 1979-06-07
DE2851427A1 (de) 1979-05-31
DK534278A (da) 1979-05-31
DK149197B (da) 1986-03-10
JPS5484542A (en) 1979-07-05
NO148885C (no) 1984-01-04
JPS6155499B2 (es) 1986-11-28
FR2410643A1 (fr) 1979-06-29
SE431448B (sv) 1984-02-06
AU520597B2 (en) 1982-02-11
SE7812247L (sv) 1979-05-31
IT1116382B (it) 1986-02-10
NL185076B (nl) 1989-08-16
GB2009176A (en) 1979-06-13
IE782253L (en) 1979-05-30
PT68816A (en) 1978-12-01
DK149197C (da) 1986-08-11
US4335256A (en) 1982-06-15
ATA847278A (de) 1980-11-15
IE47564B1 (en) 1984-04-18
FR2410643B1 (es) 1983-12-23
LU80602A1 (fr) 1979-03-22
CH636850A5 (it) 1983-06-30
GR65322B (en) 1980-08-11

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19971201