ES474130A1 - Procedimiento para la obtencion de derivados de 6-tiatetra- ciclina - Google Patents
Procedimiento para la obtencion de derivados de 6-tiatetra- ciclinaInfo
- Publication number
- ES474130A1 ES474130A1 ES474130A ES474130A ES474130A1 ES 474130 A1 ES474130 A1 ES 474130A1 ES 474130 A ES474130 A ES 474130A ES 474130 A ES474130 A ES 474130A ES 474130 A1 ES474130 A1 ES 474130A1
- Authority
- ES
- Spain
- Prior art keywords
- thiatetracyclinracemates
- preparing
- optical antipodes
- natural configuration
- thianaphtha
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D335/00—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
- C07D335/04—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
Procedimiento para la obtención de derivados de 6-tiatetraciclina, caracterizado porque mezclas de epímero de 1,44a 5,5a,6,11,12a-octahidro-3,12-dihidroxi-1,11-dioxo-6-tia- natacen-2-carboxamidas se transforman por tratamiento con una base, en caso dado en presencia de un disolvente inerte a temperaturas entre 15 y 120º con una relación de tiempo que a 20º asciende a 12 horas y a 50º aproximadamente 1 hora.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE2746044A DE2746044C2 (de) | 1977-10-13 | 1977-10-13 | Verfahren zur Herstellung von e-Thiatetracyclinracematen mit natürlicher Konfiguration und ihren optischen Antipoden |
Publications (1)
Publication Number | Publication Date |
---|---|
ES474130A1 true ES474130A1 (es) | 1980-01-16 |
Family
ID=6021351
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES474130A Expired ES474130A1 (es) | 1977-10-13 | 1978-10-11 | Procedimiento para la obtencion de derivados de 6-tiatetra- ciclina |
Country Status (9)
Country | Link |
---|---|
US (1) | US4229582A (es) |
EP (1) | EP0001558A1 (es) |
JP (1) | JPS5466681A (es) |
AU (1) | AU4069178A (es) |
DE (1) | DE2746044C2 (es) |
ES (1) | ES474130A1 (es) |
HU (1) | HU176135B (es) |
IL (1) | IL55704A0 (es) |
IT (1) | IT1109315B (es) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU753370B2 (en) * | 1998-01-23 | 2002-10-17 | Trustees Of Tufts College | Pharmaceutically active compounds and methods of use thereof |
WO2005077343A2 (de) * | 2004-02-11 | 2005-08-25 | Max-Delbrück-Centrum für Molekulare Medizin | Neue arzneimittel und diagnostische zusammensetzungen für behandlung und diagnose von neurodegenerativen erkrankungen und amyloid-krankheiten |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2437487A1 (de) * | 1974-08-03 | 1976-02-19 | Merck Patent Gmbh | 7-methoxy-6-thia-tetracycline und verfahren zu ihrer herstellung |
DE2442829A1 (de) * | 1974-09-06 | 1976-03-18 | Merck Patent Gmbh | Tetracyclische verbindungen und verfahren zu ihrer herstellung |
-
1977
- 1977-10-13 DE DE2746044A patent/DE2746044C2/de not_active Expired
-
1978
- 1978-09-20 EP EP78100939A patent/EP0001558A1/de not_active Withdrawn
- 1978-10-09 IL IL7855704A patent/IL55704A0/xx unknown
- 1978-10-11 HU HU78ME2215A patent/HU176135B/hu unknown
- 1978-10-11 ES ES474130A patent/ES474130A1/es not_active Expired
- 1978-10-12 IT IT51481/78A patent/IT1109315B/it active
- 1978-10-13 AU AU40691/78A patent/AU4069178A/en active Pending
- 1978-10-13 US US05/951,207 patent/US4229582A/en not_active Expired - Lifetime
- 1978-10-13 JP JP12520978A patent/JPS5466681A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
HU176135B (en) | 1980-12-28 |
US4229582A (en) | 1980-10-21 |
EP0001558A1 (de) | 1979-05-02 |
AU4069178A (en) | 1980-04-17 |
IT1109315B (it) | 1985-12-16 |
DE2746044B1 (de) | 1979-01-04 |
JPS5466681A (en) | 1979-05-29 |
DE2746044C2 (de) | 1979-09-06 |
IL55704A0 (en) | 1978-12-17 |
IT7851481A0 (it) | 1978-10-12 |
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