ES470430A1 - Un metodo para preparar pseudotrisacaridos - Google Patents
Un metodo para preparar pseudotrisacaridosInfo
- Publication number
- ES470430A1 ES470430A1 ES470430A ES470430A ES470430A1 ES 470430 A1 ES470430 A1 ES 470430A1 ES 470430 A ES470430 A ES 470430A ES 470430 A ES470430 A ES 470430A ES 470430 A1 ES470430 A1 ES 470430A1
- Authority
- ES
- Spain
- Prior art keywords
- compounds
- kanamycin
- active
- deoxy
- synthetic aminoglycosides
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
- C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms
- C07H15/224—Cyclohexane rings substituted by at least two nitrogen atoms with only one saccharide radical directly attached to the cyclohexyl radical, e.g. destomycin, fortimicin, neamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
- C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms
- C07H15/226—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings
- C07H15/234—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to non-adjacent ring carbon atoms of the cyclohexane rings, e.g. kanamycins, tobramycin, nebramycin, gentamicin A2
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Preparación de aminoglicósidos. En particular, la invención se refiere a un método de preparar pseudotrisacáridos que tienen actividad antibiótica. Los antibióticos bien conocidos de los tipo de la Kanamicina, Gentamicina y Apramicina son amino-pseudotrisacáridos. Los antibióticos conocidos exhiben actividad contra una amplia gama de bacterias. Sin embargo, están llegando a ser muy generalizadas cepas de bacterias que presentan resistencia a estos tipos de antibióticos. Esto constituye un problema importante debido a que las cepas resistentes de bacterias tienden a producir toxinas más peligrosas que las cepas no resistentes. La presente invención se basa en el descubrimiento de que por sustitución al menos parcial de los anillos normales de estos antibióticos por anillos desoxi pueden obtenerse compuestos que tienen una actividad notablemente mejorada cuando se comparan con los correspondientes antibióticos conocidos contra tales microorganismos resistentes.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB2400276A GB1579029A (en) | 1976-06-10 | 1976-06-10 | Synthetic aminoglycosides |
GB4549276 | 1976-11-02 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES470430A1 true ES470430A1 (es) | 1979-10-16 |
Family
ID=26256831
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES459606A Expired ES459606A1 (es) | 1976-06-10 | 1977-06-08 | Un metodo para preparar pseudotrisacaridos. |
ES470430A Expired ES470430A1 (es) | 1976-06-10 | 1978-06-01 | Un metodo para preparar pseudotrisacaridos |
ES470429A Expired ES470429A1 (es) | 1976-06-10 | 1978-06-01 | Un metodo para preparar pseudotriscaridos |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES459606A Expired ES459606A1 (es) | 1976-06-10 | 1977-06-08 | Un metodo para preparar pseudotrisacaridos. |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES470429A Expired ES470429A1 (es) | 1976-06-10 | 1978-06-01 | Un metodo para preparar pseudotriscaridos |
Country Status (7)
Country | Link |
---|---|
US (1) | US4208531A (es) |
JP (1) | JPS52156834A (es) |
DE (1) | DE2726113A1 (es) |
ES (3) | ES459606A1 (es) |
FR (1) | FR2354341A1 (es) |
NL (1) | NL7706395A (es) |
PT (1) | PT66654B (es) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4171356A (en) * | 1976-10-28 | 1979-10-16 | Schering Corporation | 2-Unsubstituted derivatives of 4,6-di-o-(aminoglycosyl)-1,3-diaminocyclitois, methods for their use as antibacterial agents and compositions useful therefor |
US7794713B2 (en) | 2004-04-07 | 2010-09-14 | Lpath, Inc. | Compositions and methods for the treatment and prevention of hyperproliferative diseases |
US7862812B2 (en) | 2006-05-31 | 2011-01-04 | Lpath, Inc. | Methods for decreasing immune response and treating immune conditions |
KR101272351B1 (ko) * | 2010-04-23 | 2013-06-07 | 이화여자대학교 산학협력단 | 새로운 카나마이신 화합물, 카나마이신 생산 스트렙토마이세스 속 미생물 및 카나마이신의 생산 방법 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE402777C (sv) * | 1972-12-29 | 1979-02-05 | Takeda Chemical Industries Ltd | Sett att framstella aminoglykosidantibiotika av 3'- och/eller 5''-dioxineomycintyp, 3'- och/eller 2''-dioxikanamycintyp eller 3''-dioxistryptomycintyp |
US4063015A (en) * | 1973-08-27 | 1977-12-13 | Schering Corporation | Garamine and derivatives thereof |
US4051315A (en) * | 1974-11-13 | 1977-09-27 | Bristol-Myers Company | 6"-Deoxykanamycin B and 6"-deoxytobramycin |
FR2290908A1 (fr) * | 1974-11-13 | 1976-06-11 | Roussel Uclaf | Nouveau derive aminoglycosidique et ses sels, leur procede de preparation et leur application comme medicaments |
-
1977
- 1977-06-08 ES ES459606A patent/ES459606A1/es not_active Expired
- 1977-06-08 PT PT66654A patent/PT66654B/pt unknown
- 1977-06-08 US US05/804,756 patent/US4208531A/en not_active Expired - Lifetime
- 1977-06-09 JP JP6873777A patent/JPS52156834A/ja active Pending
- 1977-06-10 FR FR7717881A patent/FR2354341A1/fr active Granted
- 1977-06-10 DE DE19772726113 patent/DE2726113A1/de not_active Withdrawn
- 1977-06-10 NL NL7706395A patent/NL7706395A/xx not_active Application Discontinuation
-
1978
- 1978-06-01 ES ES470430A patent/ES470430A1/es not_active Expired
- 1978-06-01 ES ES470429A patent/ES470429A1/es not_active Expired
Also Published As
Publication number | Publication date |
---|---|
DE2726113A1 (de) | 1977-12-22 |
US4208531A (en) | 1980-06-17 |
ES459606A1 (es) | 1978-12-16 |
NL7706395A (nl) | 1977-12-13 |
JPS52156834A (en) | 1977-12-27 |
FR2354341A1 (fr) | 1978-01-06 |
ES470429A1 (es) | 1979-01-01 |
FR2354341B1 (es) | 1980-03-07 |
PT66654A (en) | 1977-07-01 |
PT66654B (en) | 1978-11-10 |
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