ES470226A1 - Procedimiento para la preparacion de 4-fenil-8-amino-tetra- hidroisoquinoleinas - Google Patents
Procedimiento para la preparacion de 4-fenil-8-amino-tetra- hidroisoquinoleinasInfo
- Publication number
- ES470226A1 ES470226A1 ES470226A ES470226A ES470226A1 ES 470226 A1 ES470226 A1 ES 470226A1 ES 470226 A ES470226 A ES 470226A ES 470226 A ES470226 A ES 470226A ES 470226 A1 ES470226 A1 ES 470226A1
- Authority
- ES
- Spain
- Prior art keywords
- tetrahydroisoquinolines
- phenyl
- amino
- preparation
- compositions
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
- C07D217/04—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, ***e
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Psychiatry (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Procedimiento para la preparación de 4-fenil-8-amino-tetrahidroisoquinoleínas de la fórmula I **(Fórmula-01)** en la que R1 representa bromo y R2 hidrógeno, o tanto R1 como R2 significan cloro, y sus sales con ácidos fisiológicamente inocuos, caracterizado porque se cicliza un compuesto de la fórmula II **(Fórmula-02)** en que X significa halógeno, hidroxi, un correspondiente grupo éster de ácido carboxílico, un grupo éster de ácido sulfúrico, un grupo éster de ácido alcohilsulfónico o arilsulfónico, con un agente ciclizador ácido y a partir de ello se prepara eventualmente una sal con un ácido fisiológicamente inocuo.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19772724610 DE2724610A1 (de) | 1977-06-01 | 1977-06-01 | 4-phenyl-8-amino-tetrahydroisochinoline |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES470226A1 true ES470226A1 (es) | 1979-01-01 |
Family
ID=6010350
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES470226A Expired ES470226A1 (es) | 1977-06-01 | 1978-05-26 | Procedimiento para la preparacion de 4-fenil-8-amino-tetra- hidroisoquinoleinas |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US4185105A (es) |
| EP (1) | EP0000013B1 (es) |
| JP (1) | JPS543078A (es) |
| AT (1) | AT361482B (es) |
| AU (1) | AU517664B2 (es) |
| CA (1) | CA1093079A (es) |
| DE (2) | DE2724610A1 (es) |
| DK (1) | DK242278A (es) |
| EG (1) | EG13777A (es) |
| ES (1) | ES470226A1 (es) |
| FI (1) | FI781717A (es) |
| HU (1) | HU176978B (es) |
| IL (1) | IL54810A0 (es) |
| IT (1) | IT1094899B (es) |
| NO (1) | NO781896L (es) |
| PT (1) | PT68123A (es) |
| ZA (1) | ZA783122B (es) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4340600A (en) * | 1980-05-22 | 1982-07-20 | Smithkline Corporation | Renal dilating methods and compositions using 4-(3,4-dihydroxyphenyl)-1,2,3,4-tetrahydroisoquinolines |
| PH19604A (en) * | 1982-06-04 | 1986-05-27 | Egyt Gyogyszervegyeszeti Gyar | Isoquinoline derivatives and pharmaceutical compositions containing the same |
| DE3310878A1 (de) * | 1983-03-25 | 1984-09-27 | Hoechst Ag, 6230 Frankfurt | Optische antipoden von 8-amino-4-phenyl-1,2,3,4-tetrahydroisochinolin, verfahren zu ihrer herstellung und sie enthaltende arzneimittel mit antidepressiver wirkung |
| BG45572A1 (en) * | 1986-10-23 | 1989-07-14 | Druzhestven N Izsledovatelski | Antiulcer means |
| AU2004244672B2 (en) * | 2003-06-10 | 2011-02-10 | Resmed Limited | Multiple stage blower and enclosure therefor |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3384640A (en) * | 1966-03-15 | 1968-05-21 | Bristol Myers Co | Amino isoquinolinium salts |
| DE1670694B2 (de) * | 1966-05-05 | 1976-07-22 | Hoechst Ag, 6000 Frankfurt | Verfahren zur herstellung von tetrahydroisochinolinen |
-
1977
- 1977-06-01 DE DE19772724610 patent/DE2724610A1/de not_active Withdrawn
-
1978
- 1978-05-26 ES ES470226A patent/ES470226A1/es not_active Expired
- 1978-05-29 EG EG343/78A patent/EG13777A/xx active
- 1978-05-30 ZA ZA00783122A patent/ZA783122B/xx unknown
- 1978-05-30 FI FI781717A patent/FI781717A/fi not_active Application Discontinuation
- 1978-05-30 IT IT23996/78A patent/IT1094899B/it active
- 1978-05-30 US US05/910,781 patent/US4185105A/en not_active Expired - Lifetime
- 1978-05-30 IL IL54810A patent/IL54810A0/xx unknown
- 1978-05-31 DK DK242278A patent/DK242278A/da not_active Application Discontinuation
- 1978-05-31 AT AT395078A patent/AT361482B/de not_active IP Right Cessation
- 1978-05-31 AU AU36705/78A patent/AU517664B2/en not_active Expired
- 1978-05-31 CA CA304,518A patent/CA1093079A/en not_active Expired
- 1978-05-31 HU HU78HO2078A patent/HU176978B/hu unknown
- 1978-05-31 NO NO78781896A patent/NO781896L/no unknown
- 1978-05-31 PT PT68123A patent/PT68123A/pt unknown
- 1978-06-01 EP EP78100025A patent/EP0000013B1/de not_active Expired
- 1978-06-01 DE DE7878100025T patent/DE2860212D1/de not_active Expired
- 1978-06-01 JP JP6499278A patent/JPS543078A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| IT1094899B (it) | 1985-08-10 |
| FI781717A (fi) | 1978-12-02 |
| JPS543078A (en) | 1979-01-11 |
| EG13777A (en) | 1982-03-31 |
| HU176978B (hu) | 1981-06-28 |
| EP0000013A1 (de) | 1978-12-20 |
| PT68123A (en) | 1978-06-01 |
| DE2860212D1 (en) | 1981-01-22 |
| DK242278A (da) | 1978-12-02 |
| AU517664B2 (en) | 1981-08-20 |
| AT361482B (de) | 1981-03-10 |
| IT7823996A0 (it) | 1978-05-30 |
| US4185105A (en) | 1980-01-22 |
| ZA783122B (en) | 1979-06-27 |
| CA1093079A (en) | 1981-01-06 |
| AU3670578A (en) | 1979-12-06 |
| NO781896L (no) | 1978-12-04 |
| DE2724610A1 (de) | 1978-12-14 |
| ATA395078A (de) | 1980-08-15 |
| EP0000013B1 (de) | 1980-10-15 |
| IL54810A0 (en) | 1978-07-31 |
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