ES469423A1 - Un procedimiento para la produccion de los antibioticos antitumorales ma 144-m1 o 144-m2. - Google Patents
Un procedimiento para la produccion de los antibioticos antitumorales ma 144-m1 o 144-m2.Info
- Publication number
- ES469423A1 ES469423A1 ES469423A ES469423A ES469423A1 ES 469423 A1 ES469423 A1 ES 469423A1 ES 469423 A ES469423 A ES 469423A ES 469423 A ES469423 A ES 469423A ES 469423 A1 ES469423 A1 ES 469423A1
- Authority
- ES
- Spain
- Prior art keywords
- inhibit
- growth
- antitumor antibiotics
- staphyococcus
- cinerubin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/24—Condensed ring systems having three or more rings
- C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
- C12N1/205—Bacterial isolates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/44—Preparation of O-glycosides, e.g. glucosides
- C12P19/56—Preparation of O-glycosides, e.g. glucosides having an oxygen atom of the saccharide radical directly bound to a condensed ring system having three or more carbocyclic rings, e.g. daunomycin, adriamycin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
- C12R2001/465—Streptomyces
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
- C12R2001/465—Streptomyces
- C12R2001/48—Streptomyces antibioticus ; Actinomyces antibioticus
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/822—Microorganisms using bacteria or actinomycetales
- Y10S435/886—Streptomyces
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/822—Microorganisms using bacteria or actinomycetales
- Y10S435/886—Streptomyces
- Y10S435/888—Streptomyces antibioticus
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Medicinal Chemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Virology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
Un procedimiento para la producción de los antibióticos antitumorales Ma 144-M1 o MA 144-M2 de fórmula general. **(Fórmula)** donde R representa un átomo de hidrógeno en el caso de MA 144- M1 o un grupo hidroxilo en el caso de MA 144-M2 o una sal de adición ácida, no tóxica de los mismos, cuyo procedimiento comprende a) incubar aclacinomicina A en el caso de MA 144-M1 o cinerrubina A en el caso de MA 144-M2 a una temperatura en la gama de 20ºC a 42ºC y a un pH de entre 5,5 a 10,5 en un medio que contenga un sistema enzimático capaz de convertir la aclacinomicina A en MA 144-M1 o cinerrubina A en MA 144-M2 y una coenzima, b) opcionalmente, recuperar el MA 144-M1 o MA 144-M2 de la mezcla de reacción con o sin salificación.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP3968876A JPS52136159A (en) | 1976-04-07 | 1976-04-07 | Anti/malignanttumor containing the same as active ingredients |
Publications (1)
Publication Number | Publication Date |
---|---|
ES469423A1 true ES469423A1 (es) | 1979-04-01 |
Family
ID=12559990
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES475579A Expired ES475579A1 (es) | 1976-04-07 | 1977-04-05 | Un procedimiento para la produccion de los antibioticos an- titumorales ma 144-m1 yno ma 144 m2. |
ES469424A Expired ES469424A1 (es) | 1976-04-07 | 1978-05-03 | Un procedimiento para la produccion de los antibioticos antitumorales ma 144-m1 o ma 144-m2. |
ES469423A Expired ES469423A1 (es) | 1976-04-07 | 1978-05-03 | Un procedimiento para la produccion de los antibioticos antitumorales ma 144-m1 o 144-m2. |
Family Applications Before (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES475579A Expired ES475579A1 (es) | 1976-04-07 | 1977-04-05 | Un procedimiento para la produccion de los antibioticos an- titumorales ma 144-m1 yno ma 144 m2. |
ES469424A Expired ES469424A1 (es) | 1976-04-07 | 1978-05-03 | Un procedimiento para la produccion de los antibioticos antitumorales ma 144-m1 o ma 144-m2. |
Country Status (11)
Country | Link |
---|---|
US (2) | US4144329A (es) |
JP (1) | JPS52136159A (es) |
BE (1) | BE853203A (es) |
CA (1) | CA1097238A (es) |
DE (1) | DE2715255C3 (es) |
DK (1) | DK146342C (es) |
ES (3) | ES475579A1 (es) |
FR (1) | FR2347381A1 (es) |
GB (1) | GB1563432A (es) |
NL (1) | NL168557C (es) |
SE (1) | SE436758B (es) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4123608A (en) * | 1977-07-18 | 1978-10-31 | Bristol-Myers Company | Antibiotic compound |
ZA802929B (en) * | 1979-05-22 | 1981-05-27 | Hoffmann La Roche | Novel tetracyclic compounds and process for the preparation thereof |
JPS6023679B2 (ja) * | 1979-07-13 | 1985-06-08 | メルシャン株式会社 | ロドマイシン群抗生物質とその製造法 |
DE3071391D1 (en) * | 1979-09-07 | 1986-03-13 | Sanraku Ocean Co | 2-hydroxyaclacinomycin a, pharmaceutical composition containing it; 2-hydroxyaclavinone and fermentative process for preparing same |
JPS5767518A (en) * | 1980-09-17 | 1982-04-24 | Yamasa Shoyu Co Ltd | Radiosensitizing agent or agent for increasing effect of radiomimetic substance |
CH648327A5 (de) * | 1980-10-16 | 1985-03-15 | Hoffmann La Roche | Anthracycline. |
CA1187434A (en) * | 1981-08-11 | 1985-05-21 | Akihiro Yoshimoto | Anthracycline antibiotics and their preparation method |
JPS6133194A (ja) * | 1984-07-25 | 1986-02-17 | Sanraku Inc | 新規アントラサイクリン抗生物質 |
US20050208037A1 (en) * | 2003-10-21 | 2005-09-22 | Board Of Regents, The University Of Texas System | Thioredoxin increases redox-cycling of anticancer agents thereby sensitizes cancer cells to apoptosis |
CN104644631A (zh) * | 2015-01-31 | 2015-05-27 | 云南省第一人民医院 | 新乌头碱对k562细胞生物学特性的改变 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB846130A (en) | 1956-03-23 | 1960-08-24 | Ciba Ltd | New antibiotic and derivatives and salts thereof, preparations containing the same and process for the manufacture of these substances |
US3864480A (en) * | 1974-05-06 | 1975-02-04 | Merck & Co Inc | Cinerubin A and B As Antiparasitic Agents |
JPS5134915B2 (es) * | 1974-07-27 | 1976-09-29 | ||
JPS5323961A (en) * | 1976-08-16 | 1978-03-06 | Microbial Chem Res Found | Antitumors |
-
1976
- 1976-04-07 JP JP3968876A patent/JPS52136159A/ja active Granted
-
1977
- 1977-03-24 US US05/780,730 patent/US4144329A/en not_active Expired - Lifetime
- 1977-03-31 FR FR7709758A patent/FR2347381A1/fr active Granted
- 1977-03-31 SE SE7703760A patent/SE436758B/xx not_active IP Right Cessation
- 1977-04-04 BE BE176386A patent/BE853203A/xx not_active IP Right Cessation
- 1977-04-05 DK DK152977A patent/DK146342C/da not_active IP Right Cessation
- 1977-04-05 NL NLAANVRAGE7703753,A patent/NL168557C/xx not_active IP Right Cessation
- 1977-04-05 CA CA275,564A patent/CA1097238A/en not_active Expired
- 1977-04-05 DE DE2715255A patent/DE2715255C3/de not_active Expired
- 1977-04-05 GB GB14434/77A patent/GB1563432A/en not_active Expired
- 1977-04-05 ES ES475579A patent/ES475579A1/es not_active Expired
-
1978
- 1978-05-03 ES ES469424A patent/ES469424A1/es not_active Expired
- 1978-05-03 ES ES469423A patent/ES469423A1/es not_active Expired
-
1979
- 1979-03-05 US US06/017,525 patent/US4219622A/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
US4144329A (en) | 1979-03-13 |
US4219622A (en) | 1980-08-26 |
NL7703753A (nl) | 1977-10-11 |
ES475579A1 (es) | 1978-08-01 |
NL168557C (nl) | 1982-04-16 |
JPS5438100B2 (es) | 1979-11-19 |
DK152977A (da) | 1977-10-08 |
FR2347381A1 (fr) | 1977-11-04 |
DE2715255A1 (de) | 1977-11-10 |
FR2347381B1 (es) | 1980-10-17 |
SE436758B (sv) | 1985-01-21 |
DK146342B (da) | 1983-09-12 |
BE853203A (fr) | 1977-08-01 |
CA1097238A (en) | 1981-03-10 |
DE2715255C3 (de) | 1979-08-30 |
SE7703760L (sv) | 1977-10-08 |
GB1563432A (en) | 1980-03-26 |
DK146342C (da) | 1984-04-09 |
ES469424A1 (es) | 1979-04-01 |
DE2715255B2 (de) | 1979-01-04 |
JPS52136159A (en) | 1977-11-14 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD1A | Patent lapsed |
Effective date: 19980202 |