ES464148A1 - Piperidine derivatives - Google Patents
Piperidine derivativesInfo
- Publication number
- ES464148A1 ES464148A1 ES464148A ES464148A ES464148A1 ES 464148 A1 ES464148 A1 ES 464148A1 ES 464148 A ES464148 A ES 464148A ES 464148 A ES464148 A ES 464148A ES 464148 A1 ES464148 A1 ES 464148A1
- Authority
- ES
- Spain
- Prior art keywords
- group
- cycloalkyl
- derived
- carbon atoms
- carboxylic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/56—Nitrogen atoms
- C07D211/58—Nitrogen atoms attached in position 4
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Hydrogenated Pyridines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Procedure for the preparation of piperidine derivatives of general formula ** (Formula) where R represents a halogen atom or a hydroxy or lower alkynyloxy group, or a lower acyloxy group in which the acyl group is derived from a carboxylic acid or an aralkyloxy group R1 and R2 equal or different from each other, are halogen, sulfonamido, amino, lower alkylamino, dialkylamino lower, lower alkylsulfonyl, lower alkylsulfonamido, or lower acylamino group in which the acyl group is derived from a carboxylic acid, including trifluoroacetic acid with the group represented by R1 in. 3 or 4 position of the benzene ring, except that R1 and R2 do not represent hydrogen atoms at the same time; R3 represents a hydrogen atom, a lower alkyl or lower alkenyl group, a phenyl group or a cycloalkyl or cycloalkenyl group with 3 to 7 ring carbon atoms; R4 represents a cycloalkyl or cycloalkenyl group of 3 to 7 ring carbon atoms, an aroyl, aryl or heterocyclic group; R5, R6 and R7 each represent a hydrogen atom, a lower alkyl, lower alkenyl or benzyl group, and W represents a single bond or a lower alkylene or lower alkenylene group. (Machine-translation by Google Translate, not legally binding)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB4773876A GB1575310A (en) | 1976-11-16 | 1976-11-16 | Piperidine derivatives |
Publications (1)
Publication Number | Publication Date |
---|---|
ES464148A1 true ES464148A1 (en) | 1978-09-01 |
Family
ID=10446083
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES464148A Expired ES464148A1 (en) | 1976-11-16 | 1977-11-15 | Piperidine derivatives |
ES464149A Expired ES464149A1 (en) | 1976-11-16 | 1977-11-15 | Piperidine derivatives |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES464149A Expired ES464149A1 (en) | 1976-11-16 | 1977-11-15 | Piperidine derivatives |
Country Status (5)
Country | Link |
---|---|
JP (1) | JPS5387364A (en) |
DE (1) | DE2751181A1 (en) |
ES (2) | ES464148A1 (en) |
FR (1) | FR2370731A1 (en) |
GB (1) | GB1575310A (en) |
Families Citing this family (31)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3003843A1 (en) * | 1980-02-02 | 1981-08-13 | Chemische Werke Hüls AG, 4370 Marl | METHOD FOR PRODUCING 4-AMINO-2,2,6,6-TETRAMETHYL PIPERIDINE |
US4962115A (en) * | 1981-10-01 | 1990-10-09 | Janssen Pharmaceutica N.V. | Novel N-(3-hydroxy-4-piperidinyl)benzamide derivatives |
US5057525A (en) * | 1981-10-01 | 1991-10-15 | Janssen Pharmaceutica N.V. | Novel N-(3-hydroxy-4-piperidinyl) benzamide derivatives |
US5137896A (en) * | 1981-10-01 | 1992-08-11 | Janssen Pharmaceutica N.V. | N-(3-hydroxy-4-piperidinyl)benzamide derivatives |
FR2534255B1 (en) * | 1982-10-11 | 1985-07-12 | Delalande Sa | NOVEL 4-AROYLAMINO PIPERIDINE DERIVATIVES, PREPARATION METHOD THEREOF AND THERAPEUTIC APPLICATION THEREOF |
FR2546169B1 (en) * | 1983-05-20 | 1986-03-21 | Delalande Sa | N-OXIDES OF AMINOCYCLIC DERIVATIVES, THEIR PREPARATION PROCESS AND THEIR APPLICATION IN THERAPEUTICS |
FI95572C (en) * | 1987-06-22 | 1996-02-26 | Eisai Co Ltd | Process for the preparation of a medicament useful as a piperidine derivative or its pharmaceutical salt |
US6517811B2 (en) | 1993-05-06 | 2003-02-11 | Research Corporation Technologies, Inc. | Compounds for cancer imaging and therapy |
JP3235913B2 (en) * | 1993-07-30 | 2001-12-04 | エーザイ株式会社 | Aminobenzoic acid derivative |
AU1057101A (en) * | 1999-11-17 | 2001-05-30 | Kissei Pharmaceutical Co. Ltd. | Hydroxyethoxybenzamide derivatives and drugs containing the same |
TW200800953A (en) | 2002-10-30 | 2008-01-01 | Theravance Inc | Intermediates for preparing substituted 4-amino-1-(pyridylmethyl) piperidine |
WO2004046110A1 (en) * | 2002-11-15 | 2004-06-03 | Yamanouchi Pharmaceutical Co., Ltd. | Antagonist to melanin-concentrating hormone receptor |
WO2005007645A1 (en) | 2003-07-11 | 2005-01-27 | Theravance, Inc. | Substituted 4-amino-1-benzylpiperidine compounds |
US8673920B2 (en) | 2009-05-06 | 2014-03-18 | Merck Sharp & Dohme Corp. | Inhibitors of the renal outer medullary potassium channel |
US9073882B2 (en) | 2010-10-27 | 2015-07-07 | Merck Sharp & Dohme Corp. | Inhibitors of the renal outer medullary potassium channel |
US9056859B2 (en) | 2010-10-29 | 2015-06-16 | Merck Sharp & Dohme Corp. | Inhibitors of the renal outer medullary potassium channel |
EP2744499B1 (en) | 2011-08-19 | 2016-09-28 | Merck Sharp & Dohme Corp. | Inhibitors of the renal outer medullary potassium channel |
TW201317213A (en) | 2011-09-16 | 2013-05-01 | Merck Sharp & Dohme | Inhibitors of the renal outer medullary potassium channel |
US8999991B2 (en) | 2011-10-25 | 2015-04-07 | Merck Sharp & Dohme Corp. | Inhibitors of the renal outer medullary potassium channel |
WO2013062892A1 (en) | 2011-10-25 | 2013-05-02 | Merck Sharp & Dohme Corp. | Inhibitors of the renal outer medullary potassium channel |
EP2773206B1 (en) | 2011-10-31 | 2018-02-21 | Merck Sharp & Dohme Corp. | Inhibitors of the renal outer medullary potassium channel |
WO2013066718A2 (en) | 2011-10-31 | 2013-05-10 | Merck Sharp & Dohme Corp. | Inhibitors of the renal outer medullary potassium channel |
US9139585B2 (en) | 2011-10-31 | 2015-09-22 | Merck Sharp & Dohme Corp. | Inhibitors of the Renal Outer Medullary Potassium channel |
WO2013090271A1 (en) | 2011-12-16 | 2013-06-20 | Merck Sharp & Dohme Corp. | Inhibitors of the renal outer medullary potassium channel |
AR092031A1 (en) | 2012-07-26 | 2015-03-18 | Merck Sharp & Dohme | INHIBITORS OF THE EXTERNAL RENAL MEDULAR POTASSIUM CHANNEL |
EP2925322B1 (en) | 2012-11-29 | 2018-10-24 | Merck Sharp & Dohme Corp. | Inhibitors of the renal outer medullary potassium channel |
EP2934533B1 (en) | 2012-12-19 | 2017-11-15 | Merck Sharp & Dohme Corp. | Inhibitors of the renal outer medullary potassium channel |
US9604998B2 (en) | 2013-02-18 | 2017-03-28 | Merck Sharp & Dohme Corp. | Inhibitors of the renal outer medullary potassium channel |
EP2968288B1 (en) | 2013-03-15 | 2018-07-04 | Merck Sharp & Dohme Corp. | Inhibitors of the renal outer medullary potassium channel |
US9751881B2 (en) | 2013-07-31 | 2017-09-05 | Merck Sharp & Dohme Corp. | Inhibitors of the renal outer medullary potassium channel |
WO2016127358A1 (en) | 2015-02-12 | 2016-08-18 | Merck Sharp & Dohme Corp. | Inhibitors of renal outer medullary potassium channel |
-
1976
- 1976-11-16 GB GB4773876A patent/GB1575310A/en not_active Expired
-
1977
- 1977-11-15 ES ES464148A patent/ES464148A1/en not_active Expired
- 1977-11-15 ES ES464149A patent/ES464149A1/en not_active Expired
- 1977-11-15 FR FR7735106A patent/FR2370731A1/en active Granted
- 1977-11-16 JP JP13773577A patent/JPS5387364A/en active Pending
- 1977-11-16 DE DE19772751181 patent/DE2751181A1/en not_active Ceased
Also Published As
Publication number | Publication date |
---|---|
DE2751181A1 (en) | 1978-05-24 |
JPS5387364A (en) | 1978-08-01 |
FR2370731A1 (en) | 1978-06-09 |
FR2370731B1 (en) | 1980-05-16 |
GB1575310A (en) | 1980-09-17 |
ES464149A1 (en) | 1978-09-01 |
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