ES463633A1 - Procedimiento de preparacion de derivados de la piperidina. - Google Patents

Procedimiento de preparacion de derivados de la piperidina.

Info

Publication number
ES463633A1
ES463633A1 ES463633A ES463633A ES463633A1 ES 463633 A1 ES463633 A1 ES 463633A1 ES 463633 A ES463633 A ES 463633A ES 463633 A ES463633 A ES 463633A ES 463633 A1 ES463633 A1 ES 463633A1
Authority
ES
Spain
Prior art keywords
piperidine derivatives
relates
salts
processes
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES463633A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Anphar SA
Original Assignee
Anphar SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Anphar SA filed Critical Anphar SA
Publication of ES463633A1 publication Critical patent/ES463633A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56—Nitrogen atoms
    • C07D211/58—Nitrogen atoms attached in position 4

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Procedimiento para la preparación de derivados de las piperidina de fórmula general: ***(Ver fórmula I) en donde R representa un grupo alcoxi inferior o alqueniloxi inferior R1 y R2 iguales o diferentes entre si, son hidrógeno, halógeno, sulfonamido, amino, alquilamino inferior, dialquilamino inferior, alquilsulfonilo inferior, alquilsulfonamido inferior, o acilamino inferior en el cual el grupo acilo se deriva de un ácido carboxílico, estando el grupo acilo se deriva de un ácido carboxílico, estando el grupo representado por R1 en la posición 3 o 4 del anillo bencénico, con la salvedad de que R1 y R2 no representan átomos de hidrógeno a la vez; R3 representa un átomo de hidrógeno, un grupo alquilo inferior o alquenilo inferior, un grupo fenilo o un grupo cicloalquilo o cicloalquenilo con 3 o 7 átomos de carbono en el anillo.
ES463633A 1976-10-29 1977-10-28 Procedimiento de preparacion de derivados de la piperidina. Expired ES463633A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB45146/76A GB1586468A (en) 1976-10-29 1976-10-29 Piperidine derivatives

Publications (1)

Publication Number Publication Date
ES463633A1 true ES463633A1 (es) 1978-07-01

Family

ID=10436065

Family Applications (2)

Application Number Title Priority Date Filing Date
ES463633A Expired ES463633A1 (es) 1976-10-29 1977-10-28 Procedimiento de preparacion de derivados de la piperidina.
ES463632A Expired ES463632A1 (es) 1976-10-29 1977-10-28 Procedimiento de preparacion de derivados de la piperidina.

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES463632A Expired ES463632A1 (es) 1976-10-29 1977-10-28 Procedimiento de preparacion de derivados de la piperidina.

Country Status (7)

Country Link
US (1) US4367232A (es)
JP (1) JPS5377069A (es)
CA (1) CA1095044A (es)
DE (1) DE2747960A1 (es)
ES (2) ES463633A1 (es)
FR (1) FR2369263A1 (es)
GB (1) GB1586468A (es)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4962115A (en) * 1981-10-01 1990-10-09 Janssen Pharmaceutica N.V. Novel N-(3-hydroxy-4-piperidinyl)benzamide derivatives
US5057525A (en) * 1981-10-01 1991-10-15 Janssen Pharmaceutica N.V. Novel N-(3-hydroxy-4-piperidinyl) benzamide derivatives
US5137896A (en) * 1981-10-01 1992-08-11 Janssen Pharmaceutica N.V. N-(3-hydroxy-4-piperidinyl)benzamide derivatives
FR2534255B1 (fr) * 1982-10-11 1985-07-12 Delalande Sa Nouveaux derives de la 4-aroylamino piperidine, leur procede de preparation et leur application en therapeutique
FR2546169B1 (fr) * 1983-05-20 1986-03-21 Delalande Sa N-oxydes de derives aminocycliques, leur procede de preparation et leur application en therapeutique
GB8527052D0 (en) * 1985-11-02 1985-12-04 Beecham Group Plc Compounds
FI95572C (fi) * 1987-06-22 1996-02-26 Eisai Co Ltd Menetelmä lääkeaineena käyttökelpoisen piperidiinijohdannaisten tai sen farmaseuttisen suolan valmistamiseksi
GB9016581D0 (en) * 1990-07-27 1990-09-12 Ici Plc Fungicides
GB9016580D0 (en) * 1990-07-27 1990-09-12 Ici Plc Fungicides
TR27569A (tr) * 1992-01-24 1995-06-13 Ici Plc Yeni fungisidal asilaminobenzamidler, bunlarin hazirlanis islemleri ve bitkilerdeki mantar enfeksiyonlariyla mücadelede kullanimlari.
US5739135A (en) * 1993-09-03 1998-04-14 Bristol-Myers Squibb Company Inhibitors of microsomal triglyceride transfer protein and method
US5885983A (en) * 1996-05-10 1999-03-23 Bristol-Myers Squibb Company Inhibitors of microsomal triglyceride transfer protein and method
US5827875A (en) * 1996-05-10 1998-10-27 Bristol-Myers Squibb Company Inhibitors of microsomal triglyceride transfer protein and method
US5883109A (en) * 1996-07-24 1999-03-16 Bristol-Myers Squibb Company Method for lowering serum lipid levels employing an MTP inhibitor in combination with another cholesterol lowering drug
SE9902987D0 (sv) * 1999-08-24 1999-08-24 Astra Pharma Prod Novel compounds
ES2278729T3 (es) * 2000-03-06 2007-08-16 Acadia Pharmaceuticals Inc. Compuestos azaciclicos para usar en el tratamiento de enfermedades relacionadas con la serotonina.
US20030176461A1 (en) * 2000-04-20 2003-09-18 Egle Ian R. Aminopiperidines
GB0011838D0 (en) * 2000-05-17 2000-07-05 Astrazeneca Ab Chemical compounds
WO2002087642A2 (en) * 2001-05-01 2002-11-07 A.V. Topchiev Institute Of Petrochemical Synthesis Two-phase, water-absorbent bioadhesive composition
WO2003057698A2 (en) * 2001-12-28 2003-07-17 Acadia Pharmaceuticals, Inc. Spiroazacyclic compounds as monoamine receptor modulators
US7538222B2 (en) * 2002-06-24 2009-05-26 Acadia Pharmaceuticals, Inc. N-substituted piperidine derivatives as serotonin receptor agents
RU2320646C2 (ru) * 2002-06-24 2008-03-27 Акадиа Фармасьютикалз Инк. N-замещенные производные пиперидина в качестве агентов серотонинового рецептора
US7253186B2 (en) * 2002-06-24 2007-08-07 Carl-Magnus Andersson N-substituted piperidine derivatives as serotonin receptor agents
MY139563A (en) * 2002-09-04 2009-10-30 Bristol Myers Squibb Co Heterocyclic aromatic compounds useful as growth hormone secretagogues
CN101780080B (zh) 2003-01-16 2014-06-04 阿卡蒂亚药品公司 用于神经退行性疾病的治疗的选择性五羟色胺2a/2c受体反向激动剂
US7638570B2 (en) * 2003-02-10 2009-12-29 Nippon Shokubai Co., Ltd. Water-absorbing agent
SE0301369D0 (sv) * 2003-05-09 2003-05-09 Astrazeneca Ab Chemical compounds
US20050261278A1 (en) 2004-05-21 2005-11-24 Weiner David M Selective serotonin receptor inverse agonists as therapeutics for disease
US7820695B2 (en) * 2004-05-21 2010-10-26 Acadia Pharmaceuticals, Inc. Selective serotonin receptor inverse agonists as therapeutics for disease
NZ553702A (en) * 2004-09-27 2010-10-29 Acadia Pharm Inc Synthesis of N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl)-N'-(4-(2-methylpropyloxy)phenylmethyl)carbamide and its tartrate salt and crystalline forms
US7790899B2 (en) * 2004-09-27 2010-09-07 Acadia Pharmaceuticals, Inc. Synthesis of N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl)-N′-(4-(2-methylpropyloxy)phenylmethyl)carbamide and its tartrate salt and crystalline forms
JP2008524276A (ja) * 2004-12-20 2008-07-10 エフ．ホフマン−ラ ロシュ アーゲー ４−アミノピペリジン誘導体
CN101677971A (zh) 2007-03-19 2010-03-24 阿卡蒂亚药品公司 5-ht2a反向激动剂和拮抗剂与抗精神病药物的组合
DK2200610T3 (en) * 2007-09-21 2018-04-23 Acadia Pharm Inc ADMINISTRATION OF PIMAVANSERIN WITH OTHER AGENTS
CA2992728A1 (en) 2015-07-20 2017-01-26 Acadia Pharmaceuticals Inc. Methods for preparing n-(4-fluorobenzyl)-n-(1-methylpiperidin-4-yl)-n'-(4-(2-methylpropyloxy)phenylmethyl)carbamide and its tartrate salt and polymorphic form c
US10953000B2 (en) 2016-03-25 2021-03-23 Acadia Pharmaceuticals Inc. Combination of pimavanserin and cytochrome P450 modulators
WO2017165635A1 (en) 2016-03-25 2017-09-28 Acadia Pharmaceuticals Inc. Combination of pimavanserin and cytochrome p450 modulators
WO2018118626A1 (en) 2016-12-20 2018-06-28 Acadia Pharmaceuticals Inc. Pimavanserin alone or in combination for use in the treatment of alzheimer's disease psychosis
US11135211B2 (en) 2017-04-28 2021-10-05 Acadia Pharmaceuticals Inc. Pimavanserin for treating impulse control disorder
WO2019046167A1 (en) 2017-08-30 2019-03-07 Acadia Pharmaceuticals Inc. PIMAVANSERIN FORMULATIONS

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2745837A (en) * 1954-01-21 1956-05-15 Schering Corp Benzhydryl ethers of alkyl piperidinols
NL270803A (es) * 1960-11-09
US3342826A (en) * 1964-01-13 1967-09-19 Ile De France Heterocyclic aminoalkyl benzamides
US3963745A (en) * 1972-04-03 1976-06-15 A. H. Robins Company, Incorporated Method for controlling emesis with N-(1-substituted-3-pyrrolidinyl)benzamides and thiobenzamides
US3862139A (en) * 1972-06-23 1975-01-21 Delmar Chem Heterocyclic benzamide compounds
CA1046066A (en) * 1973-08-23 1979-01-09 Tomio Muro 1-(methylated piperidino (and pyrrolidin -1-yl)-3-(substituted phenoxy)-2-propanols
DE2513136C3 (de) 1974-03-21 1981-04-30 Anphar S.A., Madrid N-(1-Benzylpiperid-4-yl)-benzamide, Verfahren zu ihrer Herstellung und sie enthaltende pharmazeutische Präparate

Also Published As

Publication number Publication date
FR2369263A1 (fr) 1978-05-26
JPS5377069A (en) 1978-07-08
ES463632A1 (es) 1978-07-16
GB1586468A (en) 1981-03-18
US4367232A (en) 1983-01-04
CA1095044A (en) 1981-02-03
DE2747960A1 (de) 1978-05-11
FR2369263B1 (es) 1980-06-13

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