ES459405A1 - Un procedimiento para la preparacion de un compuesto de pi- perazinilpirazina. - Google Patents
Un procedimiento para la preparacion de un compuesto de pi- perazinilpirazina.Info
- Publication number
- ES459405A1 ES459405A1 ES459405A ES459405A ES459405A1 ES 459405 A1 ES459405 A1 ES 459405A1 ES 459405 A ES459405 A ES 459405A ES 459405 A ES459405 A ES 459405A ES 459405 A1 ES459405 A1 ES 459405A1
- Authority
- ES
- Spain
- Prior art keywords
- pyrazinyl
- compounds
- piperazine derivatives
- prepared
- appropriate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/20—Nitrogen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Child & Adolescent Psychology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Diabetes (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Un procedimiento para la preparación de un compuesto de piperazimil)pirazina de fórmula (* ver imagen 1) caracterizado por: Hidrolizar un compuesto de fórmula (* ver imagen 2) donde R5alfa es un heterociclo, alcanoílo, aroílo, carboalcoxi, ciano, carbamilo, N-alquilcarbamilo o N-arilcarbamilo.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US57005275A | 1975-04-21 | 1975-04-21 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES459405A1 true ES459405A1 (es) | 1978-08-16 |
Family
ID=24277994
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES447150A Expired ES447150A1 (es) | 1975-04-21 | 1976-04-19 | Un procedimiento para la preparacion de un compuesto de pi- perazinilpipazina. |
| ES459405A Expired ES459405A1 (es) | 1975-04-21 | 1977-06-01 | Un procedimiento para la preparacion de un compuesto de pi- perazinilpirazina. |
| ES459406A Expired ES459406A1 (es) | 1975-04-21 | 1977-06-01 | Un procedimiento para la preparacion de un compuesto de pi- perazinilpirazina. |
| ES459407A Expired ES459407A1 (es) | 1975-04-21 | 1977-06-01 | Un procedimiento para la preparacion de un compuesto de pi- perazinilpirazina. |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES447150A Expired ES447150A1 (es) | 1975-04-21 | 1976-04-19 | Un procedimiento para la preparacion de un compuesto de pi- perazinilpipazina. |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES459406A Expired ES459406A1 (es) | 1975-04-21 | 1977-06-01 | Un procedimiento para la preparacion de un compuesto de pi- perazinilpirazina. |
| ES459407A Expired ES459407A1 (es) | 1975-04-21 | 1977-06-01 | Un procedimiento para la preparacion de un compuesto de pi- perazinilpirazina. |
Country Status (36)
| Country | Link |
|---|---|
| JP (1) | JPS51136688A (es) |
| AR (1) | AR210349A1 (es) |
| AT (1) | AT353795B (es) |
| AU (1) | AU496854B2 (es) |
| BE (1) | BE840904A (es) |
| BG (1) | BG34185A3 (es) |
| CA (1) | CA1059128A (es) |
| CH (1) | CH619462A5 (es) |
| CS (1) | CS195726B2 (es) |
| CY (1) | CY1090A (es) |
| DD (1) | DD124599A5 (es) |
| DE (1) | DE2617205C3 (es) |
| DK (1) | DK143899C (es) |
| EG (1) | EG12387A (es) |
| ES (4) | ES447150A1 (es) |
| FI (1) | FI62666C (es) |
| FR (1) | FR2308367A1 (es) |
| GB (1) | GB1492528A (es) |
| GR (1) | GR59900B (es) |
| HK (1) | HK60380A (es) |
| HU (1) | HU172684B (es) |
| IE (1) | IE42979B1 (es) |
| IL (1) | IL49391A (es) |
| KE (1) | KE3088A (es) |
| LU (1) | LU74795A1 (es) |
| MY (1) | MY8100225A (es) |
| NL (1) | NL167692C (es) |
| NO (1) | NO146599C (es) |
| PH (1) | PH12274A (es) |
| PL (1) | PL99664B1 (es) |
| PT (1) | PT65027B (es) |
| RO (1) | RO73278A (es) |
| SE (1) | SE421695B (es) |
| SU (1) | SU638260A3 (es) |
| YU (1) | YU100676A (es) |
| ZA (1) | ZA762320B (es) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4091098A (en) * | 1977-04-25 | 1978-05-23 | Merck & Co., Inc. | 3-(1-PIPERAZINYL)-1,2,4-BENZOTRIAZINES AND N-oxides |
| US4163849A (en) | 1978-03-17 | 1979-08-07 | Merck & Co., Inc. | Piperazinylpyrazines |
| US4252816A (en) * | 1979-12-03 | 1981-02-24 | Merck & Co., Inc. | Tetrahydro-1H-1,4-diazepino(1,7-a)benzimidazoles useful as analgesic agents |
| US4339579A (en) | 1980-12-29 | 1982-07-13 | American Home Products Corporation | 2,6-Bis-(pyrrolopyrazinyl)pyrazines |
| EP0094498A3 (en) * | 1982-05-06 | 1985-04-03 | American Cyanamid Company | Antiatherosclerotic 1-piperazine derivatives |
| US4547505A (en) * | 1983-03-25 | 1985-10-15 | Degussa Aktiengesellschaft | N-Phenyl-N-'-cycloalkylalkanoylpiperazine useful as analgetics and process for its production |
| US4788290A (en) * | 1987-12-11 | 1988-11-29 | American Home Products Corporation | Serotonergic pyrazine derivatives |
| EP0580465A1 (fr) * | 1992-06-25 | 1994-01-26 | Sanofi | Nouvelle utilisation thérapeutique d'hétérocyclyl-pipérazines comme 5-HT3 agonistes et nouveaux dérivés |
| HU226859B1 (en) * | 1997-10-27 | 2009-12-28 | Neurosearch As | Phenyl- or heteroaryl-homopiperazines, their use and medicaments containing them |
| CN1348449A (zh) | 1999-04-26 | 2002-05-08 | 神经研究公司 | 杂芳基二氮杂环烷烃及其制备方法和应用 |
| MXPA02007868A (es) * | 2000-02-16 | 2003-02-10 | Neurogen Corp | Arilpirazinas sustituidas. |
| US6825198B2 (en) * | 2001-06-21 | 2004-11-30 | Pfizer Inc | 5-HT receptor ligands and uses thereof |
| KR20050025628A (ko) | 2002-07-19 | 2005-03-14 | 바이오비트럼 에이비 | 5-ｈｔ2ａ 수용체 관련 장애의 치료를 위한 신규피페라지닐-피라지논 유도체 |
| SE0202287D0 (sv) * | 2002-07-19 | 2002-07-19 | Biovitrum Ab | New compounds |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2606906A (en) * | 1948-10-14 | 1952-08-12 | American Cyanamid Co | 1-(2-pyridyl) piperazine and process of preparing same |
-
1976
- 1976-04-07 EG EG76205A patent/EG12387A/xx active
- 1976-04-07 SE SE7604093A patent/SE421695B/xx not_active IP Right Cessation
- 1976-04-07 DK DK164476A patent/DK143899C/da not_active IP Right Cessation
- 1976-04-08 NO NO761207A patent/NO146599C/no unknown
- 1976-04-09 NL NL7603800A patent/NL167692C/xx not_active IP Right Cessation
- 1976-04-09 FI FI760978A patent/FI62666C/fi not_active IP Right Cessation
- 1976-04-12 IL IL49391A patent/IL49391A/xx unknown
- 1976-04-13 AU AU12966/76A patent/AU496854B2/en not_active Expired
- 1976-04-13 PH PH18329A patent/PH12274A/en unknown
- 1976-04-13 GR GR50538A patent/GR59900B/el unknown
- 1976-04-14 CA CA250,732A patent/CA1059128A/en not_active Expired
- 1976-04-14 FR FR7610958A patent/FR2308367A1/fr active Granted
- 1976-04-15 CY CY1090A patent/CY1090A/xx unknown
- 1976-04-15 GB GB15644/76A patent/GB1492528A/en not_active Expired
- 1976-04-15 DD DD192399A patent/DD124599A5/xx unknown
- 1976-04-16 CS CS762549A patent/CS195726B2/cs unknown
- 1976-04-19 ES ES447150A patent/ES447150A1/es not_active Expired
- 1976-04-19 JP JP51043763A patent/JPS51136688A/ja active Granted
- 1976-04-20 RO RO7685688A patent/RO73278A/ro unknown
- 1976-04-20 DE DE2617205A patent/DE2617205C3/de not_active Expired
- 1976-04-20 YU YU01006/76A patent/YU100676A/xx unknown
- 1976-04-20 SU SU762346054A patent/SU638260A3/ru active
- 1976-04-20 CH CH492676A patent/CH619462A5/de not_active IP Right Cessation
- 1976-04-20 LU LU74795A patent/LU74795A1/xx unknown
- 1976-04-20 PL PL1976188912A patent/PL99664B1/pl unknown
- 1976-04-20 BE BE166282A patent/BE840904A/xx not_active IP Right Cessation
- 1976-04-20 ZA ZA762320A patent/ZA762320B/xx unknown
- 1976-04-20 AT AT288376A patent/AT353795B/de not_active IP Right Cessation
- 1976-04-20 BG BG7632968A patent/BG34185A3/xx unknown
- 1976-04-20 AR AR262930A patent/AR210349A1/es active
- 1976-04-21 IE IE828/76A patent/IE42979B1/en unknown
- 1976-04-21 HU HU76ME00001967A patent/HU172684B/hu unknown
- 1976-04-21 PT PT65027A patent/PT65027B/pt unknown
-
1977
- 1977-06-01 ES ES459405A patent/ES459405A1/es not_active Expired
- 1977-06-01 ES ES459406A patent/ES459406A1/es not_active Expired
- 1977-06-01 ES ES459407A patent/ES459407A1/es not_active Expired
-
1980
- 1980-10-02 KE KE3088A patent/KE3088A/xx unknown
- 1980-10-30 HK HK603/80A patent/HK60380A/xx unknown
-
1981
- 1981-12-30 MY MY225/81A patent/MY8100225A/xx unknown
Also Published As
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