ES450601A1 - 4,5-diaryl substituted imidazoles - Google Patents

4,5-diaryl substituted imidazoles

Info

Publication number
ES450601A1
ES450601A1 ES450601A ES450601A ES450601A1 ES 450601 A1 ES450601 A1 ES 450601A1 ES 450601 A ES450601 A ES 450601A ES 450601 A ES450601 A ES 450601A ES 450601 A1 ES450601 A1 ES 450601A1
Authority
ES
Spain
Prior art keywords
treatment
inflammatory
compounds
useful
unique properties
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES450601A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
EIDP Inc
Original Assignee
EI Du Pont de Nemours and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by EI Du Pont de Nemours and Co filed Critical EI Du Pont de Nemours and Co
Publication of ES450601A1 publication Critical patent/ES450601A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/84—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Rheumatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

4,5-diaryl-2- (substituted thio) anti-inflammatory imidazoles and their corresponding sulfoxides and sulphones, useful for the treatment of arthritis and related diseases. The compounds of this invention have exhibited unique properties in various assays of anti-inflammatory and immunoregulatory activity. The biological profiles of these compounds are different from those of non-steroidal anti-inflammatory drugs and immunosuppressive drugs. These unique properties constitute a new solution to the treatment of rheumatoid arthritis and in addition they can also be useful in the treatment of other diseases that involve altered immune states. (Machine-translation by Google Translate, not legally binding)
ES450601A 1975-08-11 1976-08-10 4,5-diaryl substituted imidazoles Expired ES450601A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US60365075A 1975-08-11 1975-08-11
US69128276A 1976-06-09 1976-06-09

Publications (1)

Publication Number Publication Date
ES450601A1 true ES450601A1 (en) 1978-01-16

Family

ID=27084480

Family Applications (2)

Application Number Title Priority Date Filing Date
ES450601A Expired ES450601A1 (en) 1975-08-11 1976-08-10 4,5-diaryl substituted imidazoles
ES461193A Expired ES461193A1 (en) 1975-08-11 1977-07-28 4,5-diaryl substituted imidazoles

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES461193A Expired ES461193A1 (en) 1975-08-11 1977-07-28 4,5-diaryl substituted imidazoles

Country Status (26)

Country Link
JP (1) JPS6011702B2 (en)
AR (2) AR215591A1 (en)
AU (1) AU508605B2 (en)
CA (1) CA1074327A (en)
CH (1) CH638791A5 (en)
DD (1) DD126244A5 (en)
DE (1) DE2635876A1 (en)
DK (1) DK361376A (en)
ES (2) ES450601A1 (en)
FI (1) FI66177C (en)
FR (1) FR2320745A1 (en)
GB (1) GB1516908A (en)
GR (1) GR61145B (en)
HU (1) HU174707B (en)
IE (1) IE44019B1 (en)
IL (1) IL50230A (en)
LU (1) LU75578A1 (en)
MX (1) MX3932E (en)
NL (1) NL7608915A (en)
NO (1) NO146571C (en)
NZ (1) NZ181731A (en)
PH (1) PH11857A (en)
PT (1) PT65464B (en)
SE (1) SE428686B (en)
SU (1) SU640662A3 (en)
YU (1) YU198176A (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK16778A (en) * 1977-02-09 1978-08-10 Du Pont IMIDAZOLE DERIVATIVES THEIR USES AND MANUFACTURE
LU77703A1 (en) * 1977-07-07 1979-03-26 Ciba Geigy Ag METHOD FOR PRODUCING BICYCLIC THIA-DIAZA COMPOUNDS
DE2963572D1 (en) * 1978-04-11 1982-10-21 Ciba Geigy Ag Mercapto-imidazole derivatives, their preparation, mercapto-imidazole derivatives for the treatment of inflammatory diseases and their pharmaceutical compositions
DE2823197A1 (en) 1978-05-24 1979-11-29 Schering Ag NEW IMIDAZOLE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND PHARMACEUTICAL PREPARATIONS CONTAINING THEM
US4308277A (en) * 1978-08-10 1981-12-29 Ciba-Geigy Corporation 2,4,5-Trisubstituted imidazolines and pharmaceutical compositions containing same
US4188397A (en) * 1978-09-22 1980-02-12 Smithkline Corporation 2,2-Alkyldiylbis(thio)bis(imidazoles)
US4215135A (en) * 1979-06-08 1980-07-29 E. I. Du Pont De Nemours And Company Antiinflammatory 2-substituted-1H-phenanthro[9,10-d]imidazoles
DE2856909A1 (en) * 1978-12-28 1980-07-17 Schering Ag NEW IMIDAZOLE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND PHARMACEUTICAL PREPARATIONS CONTAINING THEM
GB8907656D0 (en) * 1989-04-05 1989-05-17 May & Baker Ltd New compositions of matter
KR20010014288A (en) * 1997-06-30 2001-02-26 오르토-맥네일 파마슈티칼, 인코퍼레이티드 2-Substituted imidazoles useful in the treatment of inflammatory diseases
DE10222103A1 (en) * 2002-05-17 2003-11-27 Merckle Gmbh Chem Pharm Fabrik New 2-(substituted thio)-imidazole derivatives are immunomodulators and cytokine release inhibitors, useful for treating diseases associated with immune system disorders, e.g. cancer or rheumatoid arthritis

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL6614808A (en) * 1965-10-21 1967-04-24
US3651080A (en) * 1969-11-07 1972-03-21 Ciba Geigy Corp Certain substituted 2-alkylmercaptoimidazole derivatives
US3636003A (en) * 1969-11-17 1972-01-18 Geigy Chem Corp Substituted 2-mercaptoimidazole derivatives
US3714179A (en) * 1970-09-08 1973-01-30 Searle & Co 1-alkyl-2-furfurylthioimidazoles and congeners
US3707475A (en) * 1970-11-16 1972-12-26 Pfizer Antiinflammatory imidazoles

Also Published As

Publication number Publication date
CH638791A5 (en) 1983-10-14
FI66177C (en) 1984-09-10
NO762754L (en) 1977-02-14
NZ181731A (en) 1978-11-13
NO146571B (en) 1982-07-19
SE428686B (en) 1983-07-18
YU198176A (en) 1982-10-31
IL50230A0 (en) 1976-10-31
JPS6011702B2 (en) 1985-03-27
PH11857A (en) 1978-08-03
FI66177B (en) 1984-05-31
NO146571C (en) 1982-10-27
HU174707B (en) 1980-03-28
DE2635876A1 (en) 1977-03-03
IL50230A (en) 1979-07-25
DK361376A (en) 1977-02-12
SE7607615L (en) 1977-02-12
CA1074327A (en) 1980-03-25
MX3932E (en) 1981-10-02
AR218054A1 (en) 1980-05-15
AU508605B2 (en) 1980-03-27
PT65464B (en) 1978-08-02
DD126244A5 (en) 1977-07-06
IE44019L (en) 1977-02-11
IE44019B1 (en) 1981-07-29
AR215591A1 (en) 1979-10-31
ES461193A1 (en) 1978-12-01
GB1516908A (en) 1978-07-05
GR61145B (en) 1978-09-27
NL7608915A (en) 1977-02-15
PT65464A (en) 1976-09-01
FR2320745A1 (en) 1977-03-11
FI762290A (en) 1977-02-12
SU640662A3 (en) 1978-12-30
FR2320745B1 (en) 1978-12-22
AU1671176A (en) 1978-02-16
JPS5223076A (en) 1977-02-21
LU75578A1 (en) 1978-04-13

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