ES448220A1 - Form of flunisolide and the use of flunisolide to treat respiratory diseases - Google Patents

Form of flunisolide and the use of flunisolide to treat respiratory diseases

Info

Publication number
ES448220A1
ES448220A1 ES448220A ES448220A ES448220A1 ES 448220 A1 ES448220 A1 ES 448220A1 ES 448220 A ES448220 A ES 448220A ES 448220 A ES448220 A ES 448220A ES 448220 A1 ES448220 A1 ES 448220A1
Authority
ES
Spain
Prior art keywords
flunisolide
respiratory diseases
treat respiratory
compound
polymorphic form
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES448220A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Syntex USA LLC
Original Assignee
Syntex USA LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Syntex USA LLC filed Critical Syntex USA LLC
Publication of ES448220A1 publication Critical patent/ES448220A1/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/008—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0043—Nose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/0026—Oxygen-containing hetero ring cyclic ketals
    • C07J71/0031—Oxygen-containing hetero ring cyclic ketals at positions 16, 17

Abstract

A method of preparing a crystalline compound, 6 α-fluoro-11 β, 21-dihydroxy-16 α, 17 α-isopropylidendioxypregna-1,4-dien-3-20-dione, which has a particle size of less than 100 microns and a predetermined X-ray diffraction pattern, characterized in that it consists in bringing into contact another polymorphic form of said compound with a suitable liquid halogenated lower alkane for an effective time to convert substantially all the polymorphic form to the crystalline form. (Machine-translation by Google Translate, not legally binding)
ES448220A 1975-05-27 1976-05-25 Form of flunisolide and the use of flunisolide to treat respiratory diseases Expired ES448220A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US58130075A 1975-05-27 1975-05-27
US58130175A 1975-05-27 1975-05-27

Publications (1)

Publication Number Publication Date
ES448220A1 true ES448220A1 (en) 1977-11-01

Family

ID=27078279

Family Applications (1)

Application Number Title Priority Date Filing Date
ES448220A Expired ES448220A1 (en) 1975-05-27 1976-05-25 Form of flunisolide and the use of flunisolide to treat respiratory diseases

Country Status (15)

Country Link
JP (1) JPS51144719A (en)
AT (1) AT357702B (en)
AU (1) AU506080B2 (en)
CA (1) CA1075228A (en)
DE (2) DE2661037C2 (en)
ES (1) ES448220A1 (en)
FR (1) FR2361900A1 (en)
GB (1) GB1525181A (en)
HK (1) HK8580A (en)
IL (1) IL49652A (en)
MX (1) MX3864E (en)
MY (1) MY8000275A (en)
NL (1) NL191234C (en)
NZ (1) NZ180946A (en)
SE (1) SE421426B (en)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK162530C (en) * 1979-05-21 1992-03-30 Syntex Corp PROCEDURE FOR PREPARING A CRYSTALLINE MODIFICATION OF FLUNISOLIDE
EP0039369B1 (en) * 1980-05-02 1983-06-15 Schering Corporation Beclomethasone ester solvates, process for their preparation, and preparation of a formulation
GB2127689B (en) * 1982-10-05 1986-07-09 Sandoz Ltd Calcitonin inhalation compositions
US4782047A (en) * 1986-05-22 1988-11-01 Syntex Pharmaceuticals International Ltd. Aqueous steroid formulations for nasal administration
EP0437451B1 (en) * 1988-10-05 1993-06-09 The Upjohn Company Finely divided solid crystalline powders via precipitation into an anti-solvent
US5707634A (en) * 1988-10-05 1998-01-13 Pharmacia & Upjohn Company Finely divided solid crystalline powders via precipitation into an anti-solvent
DE4003272A1 (en) 1990-02-03 1991-08-08 Boehringer Ingelheim Kg NEW GAS MIXTURES AND THEIR USE IN MEDICINE PREPARATIONS
EP0835098B1 (en) * 1995-06-27 2002-09-04 Boehringer Ingelheim Pharma KG New, stable medicinal compositions for generating propellant-free aerosols
DE19653969A1 (en) * 1996-12-20 1998-06-25 Boehringer Ingelheim Kg New aqueous pharmaceutical preparation for the production of propellant-free aerosols
US20010031244A1 (en) 1997-06-13 2001-10-18 Chiesi Farmaceutici S.P.A. Pharmaceutical aerosol composition
DZ2947A1 (en) 1998-11-25 2004-03-15 Chiesi Farma Spa Pressure metered dose inhaler.
IT1313553B1 (en) 1999-07-23 2002-09-09 Chiesi Farma Spa OPTIMIZED FORMULATIONS CONSTITUTED BY SOLUTIONS OF STEROIDS GIVEN BY INHALATION.
IT1317846B1 (en) 2000-02-22 2003-07-15 Chiesi Farma Spa FORMULATIONS CONTAINING AN ANTICOLINERGIC DRUG FOR THE TREATMENT OF CHRONIC OBSTRUCTIVE BRONCOPNEUMOPATHY.
CA2411047C (en) 2000-05-22 2009-08-04 Chiesi Farmaceutici S.P.A. Stable pharmaceutical solution formulations for pressurised metered dose inhalers
SI1273292T1 (en) 2001-07-02 2004-12-31 Chiesi Farmaceutici S.P.A. Optimised formulation of tobramycin for aerosolization
JP4632687B2 (en) * 2003-04-25 2011-02-16 ロート製薬株式会社 Nasal drops
JP5238779B2 (en) * 2003-04-25 2013-07-17 ロート製薬株式会社 Nasal drops
EP1595531A1 (en) 2004-05-13 2005-11-16 CHIESI FARMACEUTICI S.p.A. Stable pharmaceutical solution formulations for pressurized metered dose inhalers
AU2014233362A1 (en) * 2013-03-15 2015-10-01 Medicis Pharmaceutical Corporation Topical compositions of flunisolide and methods of treatment

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3126375A (en) 1964-03-24 Chioacyl
GB933867A (en) * 1958-12-08 1963-08-14 American Cyanamid Co Fluorinated steroids
US3282791A (en) 1965-08-17 1966-11-01 Merck & Co Inc Inhalation aerosol suspension of anhydrous disodium dexamethasone phosphate, propellents, and sorbitan trioleate
US3592930A (en) * 1968-07-19 1971-07-13 Syntex Corp Moisture-deterioratable topical medicaments,particularly anti-inflammatory steroids,in a substantially non-aqueous fatty alcohol-propylene glycol vehicle
DE2015300A1 (en) 1969-04-01 1970-10-29 Syntex Corp., Panania;PM topical anti-inflammatory preparations and methods of their use
GB1429184A (en) * 1972-04-20 1976-03-24 Allen & Hanburys Ltd Physically anti-inflammatory steroids for use in aerosols
DE2332663C2 (en) 1973-06-23 1986-07-31 Schering AG, 1000 Berlin und 4709 Bergkamen Use of corticosteroid active ingredients for inhalation therapy
US3934013A (en) 1975-02-21 1976-01-20 Syntex (U.S.A.) Inc. Pharmaceutical composition

Also Published As

Publication number Publication date
IL49652A (en) 1979-05-31
NL191234B (en) 1994-11-01
FR2361900B1 (en) 1979-04-13
MX3864E (en) 1981-08-26
HK8580A (en) 1980-03-14
NZ180946A (en) 1978-07-28
FR2361900A1 (en) 1978-03-17
AU506080B2 (en) 1979-12-13
CA1075228A (en) 1980-04-08
DE2661037C2 (en) 1989-04-06
JPS51144719A (en) 1976-12-13
IL49652A0 (en) 1976-07-30
SE421426B (en) 1981-12-21
SE7605927L (en) 1976-11-28
GB1525181A (en) 1978-09-20
NL7605699A (en) 1976-11-30
AU1430176A (en) 1977-12-01
MY8000275A (en) 1980-12-31
DE2624924A1 (en) 1977-12-15
ATA388376A (en) 1979-12-15
DE2624924C2 (en) 1986-11-27
NL191234C (en) 1995-04-03
AT357702B (en) 1980-07-25
JPS6247880B2 (en) 1987-10-09

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