ES447902A1 - Non-amphetaminic psychostimulating compositions of 1,4-disubstituted piperazines - Google Patents
Non-amphetaminic psychostimulating compositions of 1,4-disubstituted piperazinesInfo
- Publication number
- ES447902A1 ES447902A1 ES447902A ES447902A ES447902A1 ES 447902 A1 ES447902 A1 ES 447902A1 ES 447902 A ES447902 A ES 447902A ES 447902 A ES447902 A ES 447902A ES 447902 A1 ES447902 A1 ES 447902A1
- Authority
- ES
- Spain
- Prior art keywords
- alkyl
- psychostimulating
- hydrogen
- amphetaminic
- compositions
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D295/145—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/15—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
1,4-DISUBSTITUTED PIPERAZINE DERIVATIVES HAVING THE FORMULA < IMAGE > wherein R is C1-3 alkyl, halogen or hydrogen R1 is phenyl or C1-3 alkyl R' is hydrogen when R1 is alkyl and is the same as R when R1 is phenyl R2 is hydrogen or C1-3 alkyl n is 2-4 n' is 1-4 and A is a group comprising a trivalent organic function which may be acid, ester, nitrile or amide, in which latter case the nitrogen of the amide is part of the ring, and more particularly COOH, COONa, COOCH3 or COOC2H5. These derivatives or their addition salts with pharmaceutically acceptable acids, have high psychostimulating activity.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR7514804A FR2310763A1 (en) | 1975-05-13 | 1975-05-13 | 1,4-DISUBSTITUDE DERIVATIVES OF PIPERAZINE, THEIR PREPARATION PROCESS AND THEIR APPLICATIONS |
Publications (1)
Publication Number | Publication Date |
---|---|
ES447902A1 true ES447902A1 (en) | 1977-06-16 |
Family
ID=9155135
Family Applications (5)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES447900A Expired ES447900A1 (en) | 1975-05-13 | 1976-05-13 | Non-amphetaminic psychostimulating compositions of 1,4-disubstituted piperazines |
ES447899A Expired ES447899A1 (en) | 1975-05-13 | 1976-05-13 | Non-amphetaminic psychostimulating compositions of 1,4-disubstituted piperazines |
ES447898A Expired ES447898A1 (en) | 1975-05-13 | 1976-05-13 | Non-amphetaminic psychostimulating compositions of 1,4-disubstituted piperazines |
ES447901A Expired ES447901A1 (en) | 1975-05-13 | 1976-05-13 | Non-amphetaminic psychostimulating compositions of 1,4-disubstituted piperazines |
ES447902A Expired ES447902A1 (en) | 1975-05-13 | 1976-05-13 | Non-amphetaminic psychostimulating compositions of 1,4-disubstituted piperazines |
Family Applications Before (4)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES447900A Expired ES447900A1 (en) | 1975-05-13 | 1976-05-13 | Non-amphetaminic psychostimulating compositions of 1,4-disubstituted piperazines |
ES447899A Expired ES447899A1 (en) | 1975-05-13 | 1976-05-13 | Non-amphetaminic psychostimulating compositions of 1,4-disubstituted piperazines |
ES447898A Expired ES447898A1 (en) | 1975-05-13 | 1976-05-13 | Non-amphetaminic psychostimulating compositions of 1,4-disubstituted piperazines |
ES447901A Expired ES447901A1 (en) | 1975-05-13 | 1976-05-13 | Non-amphetaminic psychostimulating compositions of 1,4-disubstituted piperazines |
Country Status (5)
Country | Link |
---|---|
US (1) | US4096259A (en) |
DE (1) | DE2621082C2 (en) |
ES (5) | ES447900A1 (en) |
FR (1) | FR2310763A1 (en) |
GB (1) | GB1528862A (en) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4567264A (en) * | 1983-05-18 | 1986-01-28 | Syntex (U.S.A.) Inc. | Cardioselective aryloxy- and arylthio- hydroxypropylene-piperazinyl acetanilides which affect calcium entry |
GB8320701D0 (en) * | 1983-08-01 | 1983-09-01 | Wellcome Found | Chemotherapeutic agent |
FR2603583B1 (en) * | 1986-09-05 | 1988-12-09 | Andre Buzas | BENZHYDRYLOXYETHYL-PIPERIDINE DERIVATIVES, PROCESS FOR OBTAINING SAME AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
DK178590D0 (en) * | 1990-07-26 | 1990-07-26 | Novo Nordisk As | 1,4-DISUBSTITUTED PIPERAZINES |
US5276035A (en) * | 1990-07-26 | 1994-01-04 | Novo Nordisk A/S | 1,4-disubstituted piperazines |
DK178490D0 (en) * | 1990-07-26 | 1990-07-26 | Novo Nordisk As | 1,4-DISUBSTITUTED PIPERAZINES |
FR2815031A1 (en) * | 2000-10-11 | 2002-04-12 | Gilles Fillion | Heterocyclic and carbocyclic compounds have serotoninergic transmission modifying properties for the treatment of central and peripheral nervous disorders |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2953568A (en) * | 1958-03-03 | 1960-09-20 | Ciba Pharm Prod Inc | Derivatives of piperazine |
US3205134A (en) * | 1961-11-14 | 1965-09-07 | Colgate Palmolive Co | Antidepressant benzilates of piperazinoalkanols |
DE1795375A1 (en) | 1968-09-21 | 1972-01-05 | Boehringer Mannheim Gmbh | Basic ethers and methods of making them |
FR2073277A1 (en) | 1969-12-17 | 1971-10-01 | Ferlux | 1-phenoxy alkyl-4-hydroxy alkyl piperazine - anti-inflammatories and analgesics |
-
1975
- 1975-05-13 FR FR7514804A patent/FR2310763A1/en active Granted
-
1976
- 1976-05-07 GB GB18937/76A patent/GB1528862A/en not_active Expired
- 1976-05-10 US US05/684,846 patent/US4096259A/en not_active Expired - Lifetime
- 1976-05-12 DE DE2621082A patent/DE2621082C2/en not_active Expired
- 1976-05-13 ES ES447900A patent/ES447900A1/en not_active Expired
- 1976-05-13 ES ES447899A patent/ES447899A1/en not_active Expired
- 1976-05-13 ES ES447898A patent/ES447898A1/en not_active Expired
- 1976-05-13 ES ES447901A patent/ES447901A1/en not_active Expired
- 1976-05-13 ES ES447902A patent/ES447902A1/en not_active Expired
Also Published As
Publication number | Publication date |
---|---|
ES447898A1 (en) | 1977-07-16 |
DE2621082C2 (en) | 1986-02-13 |
GB1528862A (en) | 1978-10-18 |
FR2310763A1 (en) | 1976-12-10 |
ES447899A1 (en) | 1977-07-01 |
FR2310763B1 (en) | 1978-08-04 |
ES447900A1 (en) | 1977-06-16 |
US4096259A (en) | 1978-06-20 |
ES447901A1 (en) | 1977-06-16 |
DE2621082A1 (en) | 1976-11-25 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD1A | Patent lapsed |
Effective date: 19880222 |