ES439430A1 - Stilbene derivatives - Google Patents
Stilbene derivativesInfo
- Publication number
- ES439430A1 ES439430A1 ES439430A ES439430A ES439430A1 ES 439430 A1 ES439430 A1 ES 439430A1 ES 439430 A ES439430 A ES 439430A ES 439430 A ES439430 A ES 439430A ES 439430 A1 ES439430 A1 ES 439430A1
- Authority
- ES
- Spain
- Prior art keywords
- defined above
- stilbene derivatives
- general formula
- lower alcohol
- hydrogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- PJANXHGTPQOBST-UHFFFAOYSA-N stilbene Chemical class C=1C=CC=CC=1C=CC1=CC=CC=C1 PJANXHGTPQOBST-UHFFFAOYSA-N 0.000 title abstract 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 1
- 230000001476 alcoholic effect Effects 0.000 abstract 1
- 239000003513 alkali Substances 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004438 haloalkoxy group Chemical group 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 150000002431 hydrogen Chemical class 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 230000003301 hydrolyzing effect Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000003960 organic solvent Substances 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/194—Radicals derived from thio- or thiono carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
- C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
- C07C49/794—Ketones containing a keto group bound to a six-membered aromatic ring having unsaturation outside an aromatic ring
- C07C49/796—Ketones containing a keto group bound to a six-membered aromatic ring having unsaturation outside an aromatic ring polycyclic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
- C07C49/80—Ketones containing a keto group bound to a six-membered aromatic ring containing halogen
- C07C49/813—Ketones containing a keto group bound to a six-membered aromatic ring containing halogen polycyclic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
- C07C57/30—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings
- C07C57/42—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings having unsaturation outside the rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
- C07C57/52—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen
- C07C57/58—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen containing six-membered aromatic rings
- C07C57/60—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen containing six-membered aromatic rings having unsaturation outside the rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
- C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
A procedure that prepares new stilbene derivatives represented by the general formula (I) ** (See formula) ** wherein R1 and R2 are independently hydrogen, lower alcohol, lower alkoxy, halogen, or haloalkoxy, and R3 is hydrogen or lower alcohol, which comprises hydrolyzing the compounds represented by the general formula (II) where R1 and R2 are as defined above and M is -HC (R3) CN, where R3 is as defined above, -CH2C (S) B, where B is amino, -HC (R3) C00A, where R3 is as defined above and A, is alcoholic, or -C (R3) (C00A) 2 where R3 and A are as defined above, in water, an organic solvent, or a mixture of the same, in the presence of acid or alkali, and then decarboxylate when M is -C (R3) (C00A) 2. (Machine-translation by Google Translate, not legally binding)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP49081299A JPS5111748A (en) | 1974-07-16 | 1974-07-16 | Suchirubenjudotaino seizoho |
Publications (1)
Publication Number | Publication Date |
---|---|
ES439430A1 true ES439430A1 (en) | 1977-02-01 |
Family
ID=13742501
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES439430A Expired ES439430A1 (en) | 1974-07-16 | 1975-07-15 | Stilbene derivatives |
Country Status (12)
Country | Link |
---|---|
JP (1) | JPS5111748A (en) |
AR (1) | AR205387A1 (en) |
AU (1) | AU470771B2 (en) |
CA (1) | CA1053257A (en) |
CH (1) | CH610582A5 (en) |
DE (1) | DE2531456A1 (en) |
ES (1) | ES439430A1 (en) |
FR (1) | FR2278332A1 (en) |
GB (1) | GB1465661A (en) |
NL (1) | NL7507803A (en) |
PH (1) | PH11312A (en) |
SE (1) | SE409452B (en) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2832213A1 (en) * | 1978-07-21 | 1980-01-31 | Bayer Ag | STILEN DERIVATIVES, METHOD FOR THEIR PRODUCTION AND THEIR USE AS INSECTICIDES |
DE2944428C2 (en) * | 1979-11-03 | 1984-08-30 | Trützschler GmbH & Co KG, 4050 Mönchengladbach | Device for production control and sliver regulation of a card |
FR2492815A1 (en) * | 1980-10-23 | 1982-04-30 | Sori Soc Rech Ind | NEW CINNAMOYL-CINNAMIC ACID DERIVATIVE, PREPARATION METHOD AND THERAPEUTIC APPLICATION THEREOF |
SE8400239D0 (en) * | 1984-01-19 | 1984-01-19 | Pharmacia Ab | NEW ARYLETIC ACID DERIVATIVES |
CH659814A5 (en) * | 1984-03-27 | 1987-02-27 | Ciba Geigy Ag | STYLE DERIVATIVES. |
TWI262185B (en) * | 1999-10-01 | 2006-09-21 | Eisai Co Ltd | Carboxylic acid derivatives having anti-hyperglycemia and anti-hyperlipemia action, and pharmaceutical composition containing the derivatives |
CA2393297C (en) * | 1999-12-06 | 2010-10-05 | Welichem Biotech Inc. | Polyhydroxystilbenes as antipsoriatic agents and protein kinase inhibitors |
US7321050B2 (en) | 1999-12-06 | 2008-01-22 | Welichem Biotech Inc. | Anti-inflammatory and psoriasis treatment and protein kinase inhibition by hydroxy stilbenes and novel stilbene derivatives and analogues |
ITMI20012434A1 (en) * | 2001-11-20 | 2003-05-20 | Dompe Spa | 2-ARYL-PROPIONIC ACIDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
AU2016263161B2 (en) | 2015-05-21 | 2019-02-28 | Dermavant Sciences GmbH | Topical pharmaceutical compositions |
US11617724B2 (en) | 2015-05-21 | 2023-04-04 | Dermavant Sciences GmbH | Topical pharmaceutical compositions |
CN111511357B (en) | 2017-11-10 | 2024-04-09 | 德玛万科学有限责任公司 | Process for preparing tazicar |
US11497718B2 (en) | 2018-11-13 | 2022-11-15 | Dermavant Sciences GmbH | Use of tapinarof for the treatment of atopic dermatitis |
-
1974
- 1974-07-16 JP JP49081299A patent/JPS5111748A/en active Granted
-
1975
- 1975-01-01 AR AR259394A patent/AR205387A1/en active
- 1975-06-13 GB GB2539075A patent/GB1465661A/en not_active Expired
- 1975-06-17 AU AU82152/75A patent/AU470771B2/en not_active Expired
- 1975-06-26 PH PH17515A patent/PH11312A/en unknown
- 1975-07-01 NL NL7507803A patent/NL7507803A/en not_active Application Discontinuation
- 1975-07-14 DE DE19752531456 patent/DE2531456A1/en not_active Withdrawn
- 1975-07-15 ES ES439430A patent/ES439430A1/en not_active Expired
- 1975-07-15 CA CA231,559A patent/CA1053257A/en not_active Expired
- 1975-07-15 CH CH921275A patent/CH610582A5/en not_active IP Right Cessation
- 1975-07-15 SE SE7508074A patent/SE409452B/en unknown
- 1975-07-15 FR FR7522113A patent/FR2278332A1/en active Granted
Also Published As
Publication number | Publication date |
---|---|
SE409452B (en) | 1979-08-20 |
CA1053257A (en) | 1979-04-24 |
AR205387A1 (en) | 1976-04-30 |
SE7508074L (en) | 1976-01-19 |
AU8215275A (en) | 1976-03-25 |
GB1465661A (en) | 1977-02-23 |
PH11312A (en) | 1977-11-02 |
DE2531456A1 (en) | 1976-02-05 |
FR2278332B1 (en) | 1980-05-16 |
CH610582A5 (en) | 1979-04-30 |
JPS5111748A (en) | 1976-01-30 |
FR2278332A1 (en) | 1976-02-13 |
AU470771B2 (en) | 1976-03-25 |
JPS5227B2 (en) | 1977-01-05 |
NL7507803A (en) | 1976-01-20 |
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