ES422450A1 - Procedimiento para la preparacion de nuevas imidazo (4,5-b)piridinas. - Google Patents
Procedimiento para la preparacion de nuevas imidazo (4,5-b)piridinas.Info
- Publication number
- ES422450A1 ES422450A1 ES422450A ES422450A ES422450A1 ES 422450 A1 ES422450 A1 ES 422450A1 ES 422450 A ES422450 A ES 422450A ES 422450 A ES422450 A ES 422450A ES 422450 A1 ES422450 A1 ES 422450A1
- Authority
- ES
- Spain
- Prior art keywords
- radicals
- compound
- hydrogen
- halogen atom
- carbon atoms
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000003222 pyridines Chemical class 0.000 title 1
- -1 alcoholic Chemical group 0.000 abstract 8
- 125000005843 halogen group Chemical group 0.000 abstract 7
- 150000001875 compounds Chemical class 0.000 abstract 5
- 125000004432 carbon atom Chemical group C* 0.000 abstract 4
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 4
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 125000004356 hydroxy functional group Chemical group O* 0.000 abstract 3
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 abstract 2
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 2
- 150000007522 mineralic acids Chemical class 0.000 abstract 2
- 150000007524 organic acids Chemical class 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- LKUAPSRIYZLAAO-UHFFFAOYSA-N 1-(2-phenylethyl)piperazine Chemical compound C1CNCCN1CCC1=CC=CC=C1 LKUAPSRIYZLAAO-UHFFFAOYSA-N 0.000 abstract 1
- LBZRSMXDQAFGND-UHFFFAOYSA-N 4-(4-methylpiperazin-1-yl)morpholine Chemical compound C1CN(C)CCN1N1CCOCC1 LBZRSMXDQAFGND-UHFFFAOYSA-N 0.000 abstract 1
- GAMYYCRTACQSBR-UHFFFAOYSA-N 4-azabenzimidazole Chemical class C1=CC=C2NC=NC2=N1 GAMYYCRTACQSBR-UHFFFAOYSA-N 0.000 abstract 1
- 150000001204 N-oxides Chemical class 0.000 abstract 1
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical group [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 1
- 230000001476 alcoholic effect Effects 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000003282 alkyl amino group Chemical group 0.000 abstract 1
- 125000005336 allyloxy group Chemical group 0.000 abstract 1
- 150000001412 amines Chemical class 0.000 abstract 1
- 125000003277 amino group Chemical group 0.000 abstract 1
- 125000000051 benzyloxy group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])O* 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 125000005805 dimethoxy phenyl group Chemical group 0.000 abstract 1
- RCCPEORTSYDPMB-UHFFFAOYSA-N hydroxy benzenecarboximidothioate Chemical compound OSC(=N)C1=CC=CC=C1 RCCPEORTSYDPMB-UHFFFAOYSA-N 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 abstract 1
- 239000007800 oxidant agent Substances 0.000 abstract 1
- YZTJYBJCZXZGCT-UHFFFAOYSA-N phenylpiperazine Chemical compound C1CNCCN1C1=CC=CC=C1 YZTJYBJCZXZGCT-UHFFFAOYSA-N 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/192—Radicals derived from carboxylic acids from aromatic carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/194—Radicals derived from thio- or thiono carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D339/00—Heterocyclic compounds containing rings having two sulfur atoms as the only ring hetero atoms
- C07D339/02—Five-membered rings
- C07D339/06—Five-membered rings having the hetero atoms in positions 1 and 3, e.g. cyclic dithiocarbonates
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE2305339A DE2305339C3 (de) | 1973-02-03 | 1973-02-03 | Imidazo [4,5-b] pyridine, ihre Herstellung und ihre Verwendung als Cardiötonica |
DE2361757A DE2361757A1 (de) | 1973-12-12 | 1973-12-12 | Neue imidazo eckige klammer auf 4,5-b eckige klammer zu pyridine |
Publications (1)
Publication Number | Publication Date |
---|---|
ES422450A1 true ES422450A1 (es) | 1976-05-01 |
Family
ID=25764640
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES422450A Expired ES422450A1 (es) | 1973-02-03 | 1974-01-19 | Procedimiento para la preparacion de nuevas imidazo (4,5-b)piridinas. |
Country Status (24)
Country | Link |
---|---|
JP (1) | JPS5748556B2 (ja) |
AT (1) | AT332873B (ja) |
BG (1) | BG23902A3 (ja) |
CA (1) | CA1041502A (ja) |
CH (1) | CH605939A5 (ja) |
CS (1) | CS200169B2 (ja) |
DD (1) | DD108989A5 (ja) |
DK (1) | DK140760B (ja) |
ES (1) | ES422450A1 (ja) |
FI (1) | FI58126C (ja) |
FR (1) | FR2215968B1 (ja) |
GB (1) | GB1445824A (ja) |
HK (1) | HK4080A (ja) |
HU (1) | HU170909B (ja) |
IE (1) | IE39066B1 (ja) |
IL (1) | IL44127A (ja) |
NL (1) | NL173645C (ja) |
NO (1) | NO139386C (ja) |
PH (1) | PH14988A (ja) |
PL (1) | PL93127B1 (ja) |
RO (2) | RO84276B (ja) |
SE (1) | SE411451B (ja) |
SU (2) | SU563917A3 (ja) |
YU (2) | YU36955B (ja) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS49109394A (ja) * | 1973-02-27 | 1974-10-17 | ||
DE3132754A1 (de) * | 1981-08-19 | 1983-03-03 | Merck Patent Gmbh, 6100 Darmstadt | "2-aryl-imidazo(4,5-b)pyridine, diese enthaltende pharmazeutische zubereitungen und verfahren zu ihrer herstellung" |
ES517193A0 (es) * | 1981-11-10 | 1983-12-01 | Wellcome Found | Un procedimiento para la preparacion de nuevos derivados de imidazo (4,5-c)piridina. |
RO86850B (ro) * | 1982-05-03 | 1985-05-31 | Eli Lilly And Company | Procedeu pentru prepararea unor 2-fenilimidazo [4,5 c] piridine |
US4772600A (en) * | 1986-06-09 | 1988-09-20 | A. H. Robins Company, Inc. | Fused imidazoheterocyclic compounds and pharmaceutical compositions |
JPH01190663A (ja) * | 1988-01-22 | 1989-07-31 | Terumo Corp | システアミン誘導体及びこれを含有する抗リウマチ剤 |
US6653309B1 (en) | 1999-04-26 | 2003-11-25 | Vertex Pharmaceuticals Incorporated | Inhibitors of IMPDH enzyme technical field of the invention |
EP2539706B1 (en) | 2010-02-24 | 2015-03-04 | Research Triangle Institute | Arylpiperazine opioid receptor antagonists |
CN103261170B (zh) * | 2010-12-24 | 2016-08-24 | 住友化学株式会社 | 稠杂环化合物及其用于害虫防治的用途 |
WO2013191189A1 (ja) * | 2012-06-21 | 2013-12-27 | 住友化学株式会社 | 縮合複素環化合物 |
BR112014031584A2 (pt) | 2012-06-22 | 2017-06-27 | Sumitomo Chemical Co | composto heterocíclico fundido |
-
1973
- 1973-12-27 FI FI3989/73A patent/FI58126C/fi active
-
1974
- 1974-01-10 AT AT16474*#A patent/AT332873B/de not_active IP Right Cessation
- 1974-01-19 ES ES422450A patent/ES422450A1/es not_active Expired
- 1974-01-23 BG BG025577A patent/BG23902A3/xx unknown
- 1974-01-23 CS CS74443A patent/CS200169B2/cs unknown
- 1974-01-24 YU YU0176/74A patent/YU36955B/xx unknown
- 1974-01-29 SU SU7401990335A patent/SU563917A3/ru active
- 1974-01-30 NL NLAANVRAGE7401254,A patent/NL173645C/xx not_active IP Right Cessation
- 1974-01-31 RO RO106042A patent/RO84276B/ro unknown
- 1974-01-31 CH CH136374A patent/CH605939A5/xx not_active IP Right Cessation
- 1974-01-31 RO RO7477478A patent/RO79057A/ro unknown
- 1974-02-01 SE SE7401393A patent/SE411451B/xx unknown
- 1974-02-01 FR FR7403491A patent/FR2215968B1/fr not_active Expired
- 1974-02-01 GB GB480874A patent/GB1445824A/en not_active Expired
- 1974-02-01 DD DD176324A patent/DD108989A5/xx unknown
- 1974-02-01 HU HU74TO00000951A patent/HU170909B/hu unknown
- 1974-02-01 NO NO740327A patent/NO139386C/no unknown
- 1974-02-01 JP JP49013568A patent/JPS5748556B2/ja not_active Expired
- 1974-02-01 IL IL44127A patent/IL44127A/en unknown
- 1974-02-01 DK DK56374AA patent/DK140760B/da not_active IP Right Cessation
- 1974-02-01 IE IE195/74A patent/IE39066B1/en unknown
- 1974-02-01 CA CA191,585A patent/CA1041502A/en not_active Expired
- 1974-02-02 PL PL1974168533A patent/PL93127B1/pl unknown
-
1975
- 1975-08-27 SU SU752170503A patent/SU634673A3/ru active
-
1976
- 1976-05-25 PH PH18455A patent/PH14988A/en unknown
-
1980
- 1980-01-31 HK HK40/80A patent/HK4080A/xx unknown
- 1980-04-22 YU YU1104/80A patent/YU36956B/xx unknown
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ES370394A1 (es) | Procedimiento para la preparacion de nuevas 5-11-dihidro-6h-pirido (2,3-b) (1,4) benzodiazepin-6-ona y sus sales. | |
ES413188A1 (es) | Procedimiento para preparar un derivado de 2-alquil-3-acil-pirazol (1,5-a) piridina. | |
ES8600305A1 (es) | Procedimiento de preparar compuestos beta-lactamicos | |
EP0348341A3 (de) | Aminoalkylindole, Verfahren zu deren Herstellung und diese enthaltende pharmazeutische Präparate | |
DK633088A (da) | Kollagenaseinhibitorer | |
ES422450A1 (es) | Procedimiento para la preparacion de nuevas imidazo (4,5-b)piridinas. | |
ES395714A1 (es) | Procedimiento para la obtencion de derivados de piridoqui- nolina. | |
SE7710873L (sv) | Nya 1h-pyrazolo(3,4-b)pyridiner | |
ES8604543A1 (es) | Procedimiento para la obtencion de derivados piperazinicos | |
ES404592A1 (es) | Procedimiento para la preparacion de 2,3-dihidro-oxo-imida-zo (1,2-a) - pirimidinas. | |
ES422738A1 (es) | Procedimiento para la obtencion de compuestos heterocicli- cos a base de piperazina u homopiperazina n-aciladas. | |
ES401590A1 (es) | Procedimiento para la preparacion de nuevas pirido (3,2-d) pirimidinas. | |
ES417700A1 (es) | Procedimiento para la preparacion de benceno-1,3-disulfona-midas sustituidas con radicales basicos. | |
CA1246583A (en) | 4-ISOXAZOLYL)-THIAZOLE-2-OXAMIC ACIDS AND THEIR DERIVATIVES | |
ES8702421A1 (es) | Procedimiento para preparar nuevos pirimido (2,1-b) benzo- tiazoles | |
ES309174A1 (es) | Procedimiento para la preparacion de nuevos compuestos heterociclicos condensados. | |
ES417471A1 (es) | Procedimiento para la preparacion de derivados de n(6)-a- ralcohil-adenosina acilados. | |
ES394967A1 (es) | Procedimiento para la preparacion de 3-alcohil-5-ariloxime-tilisoxazoles. | |
ES452391A1 (es) | Procedimiento para la preparacion de nuevas arilalcohilami- nas sustituidas. | |
ES274908A1 (es) | Procedimiento para la preparaciën de nuevos derivados de iminodibencilo | |
ES442612A1 (es) | Procedimiento para la obtencion de nuevos derivados de iso- quinoleina. | |
ES419660A1 (es) | Un procedimiento para la preparacion de nuevos derivados deisoquinoleina. | |
ES2085738T3 (es) | Derivados de tetrahidronaftaleno su preparacion y su aplicacion en terapeutica. | |
ES422737A1 (es) | Procedimiento para la obtencion de compuestos heterocicli- cos a base de piperazina u homopiperazina. | |
ES8601972A1 (es) | Procedimiento de obtencion de 1,2-diazin-3 (2h)-onas con interes farmaceutico |