ES414671A1 - Procedure for the preparation of 2-amino-bencilaminas. (Machine-translation by Google Translate, not legally binding) - Google Patents
Procedure for the preparation of 2-amino-bencilaminas. (Machine-translation by Google Translate, not legally binding)Info
- Publication number
- ES414671A1 ES414671A1 ES414671A ES414671A ES414671A1 ES 414671 A1 ES414671 A1 ES 414671A1 ES 414671 A ES414671 A ES 414671A ES 414671 A ES414671 A ES 414671A ES 414671 A1 ES414671 A1 ES 414671A1
- Authority
- ES
- Spain
- Prior art keywords
- signifies
- general formula
- translation
- amino
- procedure
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/04—Preparation of carboxylic acid amides from ketenes by reaction with ammonia or amines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C291/00—Compounds containing carbon and nitrogen and having functional groups not covered by groups C07C201/00 - C07C281/00
- C07C291/02—Compounds containing carbon and nitrogen and having functional groups not covered by groups C07C201/00 - C07C281/00 containing nitrogen-oxide bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/14—Antitussive agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/16—Central respiratory analeptics
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pulmonology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyridine Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
Procedure for the preparation of 2-amino-benzylamines of the general formula I **(See formula)** where Hal signifies a chlorine or bromine atom, R1 signifies a hydrogen, chlorine or bromine atom, R2 signifies a cyclohexyl, hydroxycyclohexyl, morpholinocarbonylmethyl or isopropylaminocarbonylmethyl radical, R3 signifies a hydrogen atom or a methyl group and R4 signifies a hydrogen atom or, in case R2 represents an isopropylaminocarbonylmethyl or morpholinocarbmilmethyl radical, it means the benzoyl radical, characterized in that an aldehyde of the general formula II is reacted **(See formula)** where Hal, R1 and R4 are as initially defined, with an amine of general formula III, **(See formula)** wherein R2 and R3 are as initially defined, in the presence of formic acid or the corresponding formamide at elevated temperatures and, if R3 in a compound of general formula III represents a hydrogen atom, it is heated under reflux then the reaction mixture obtained with a dilute acid. (Machine-translation by Google Translate, not legally binding)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE2223193A DE2223193C3 (en) | 1972-05-12 | 1972-05-12 | Process for the preparation of 2-amino-benzylamines |
Publications (1)
Publication Number | Publication Date |
---|---|
ES414671A1 true ES414671A1 (en) | 1976-02-01 |
Family
ID=5844732
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES414671A Expired ES414671A1 (en) | 1972-05-12 | 1973-05-11 | Procedure for the preparation of 2-amino-bencilaminas. (Machine-translation by Google Translate, not legally binding) |
Country Status (20)
Country | Link |
---|---|
JP (3) | JPS5517020B2 (en) |
KR (1) | KR780000152B1 (en) |
AT (1) | AT321885B (en) |
BG (1) | BG22382A3 (en) |
CA (1) | CA996109A (en) |
CH (1) | CH579019A5 (en) |
CS (1) | CS179415B2 (en) |
DD (1) | DD108278A5 (en) |
DE (1) | DE2223193C3 (en) |
DK (1) | DK150847C (en) |
ES (1) | ES414671A1 (en) |
FI (1) | FI56672C (en) |
HU (1) | HU165627B (en) |
NL (1) | NL158167B (en) |
NO (1) | NO135707C (en) |
PL (1) | PL89241B1 (en) |
RO (1) | RO70464A (en) |
SE (2) | SE396594B (en) |
SU (1) | SU501668A3 (en) |
YU (1) | YU35572B (en) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2423483A2 (en) * | 1978-04-20 | 1979-11-16 | Boehringer Sohn Ingelheim | PROCESS FOR PREPARING SULFUR N-BENZYL-AMINOACIDS |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE1518375A1 (en) * | 1965-06-08 | 1969-08-14 | Thomae Gmbh Dr K | Process for the preparation of new 2-amino-halobenzylamines |
DE2218647A1 (en) * | 1972-04-18 | 1973-10-25 | Thomae Gmbh Dr K | Secretolytic n-(trans-4-hydroxycyclohexyl)-2-amino-3,5- - dibromobenzylamine prepn - by redn of n-(2-amino-3,5-dibromobenzylide |
-
1972
- 1972-05-12 DE DE2223193A patent/DE2223193C3/en not_active Expired
-
1973
- 1973-04-24 KR KR7300654A patent/KR780000152B1/en active
- 1973-05-02 AT AT384973A patent/AT321885B/en not_active IP Right Cessation
- 1973-05-07 RO RO7374699A patent/RO70464A/en unknown
- 1973-05-09 DD DD170733A patent/DD108278A5/xx unknown
- 1973-05-10 BG BG23564A patent/BG22382A3/xx unknown
- 1973-05-10 HU HUTO907A patent/HU165627B/hu unknown
- 1973-05-10 CS CS7300003325A patent/CS179415B2/en unknown
- 1973-05-10 SE SE7306631A patent/SE396594B/en unknown
- 1973-05-10 YU YU1232/73A patent/YU35572B/en unknown
- 1973-05-10 CH CH666173A patent/CH579019A5/xx not_active IP Right Cessation
- 1973-05-10 JP JP5202873A patent/JPS5517020B2/ja not_active Expired
- 1973-05-10 NL NL7306513.A patent/NL158167B/en not_active IP Right Cessation
- 1973-05-11 NO NO1957/73A patent/NO135707C/no unknown
- 1973-05-11 SU SU1919018A patent/SU501668A3/en active
- 1973-05-11 FI FI1520/73A patent/FI56672C/en active
- 1973-05-11 DK DK261873A patent/DK150847C/en not_active IP Right Cessation
- 1973-05-11 ES ES414671A patent/ES414671A1/en not_active Expired
- 1973-05-11 PL PL1973162473A patent/PL89241B1/pl unknown
- 1973-05-11 CA CA171,045A patent/CA996109A/en not_active Expired
-
1976
- 1976-02-25 SE SE7602405A patent/SE421791B/en unknown
-
1977
- 1977-06-29 JP JP7769177A patent/JPS53116339A/en active Pending
- 1977-12-20 JP JP15347577A patent/JPS53149944A/en active Granted
Also Published As
Publication number | Publication date |
---|---|
FI56672C (en) | 1980-03-10 |
DD108278A5 (en) | 1974-09-12 |
AT321885B (en) | 1975-04-25 |
KR780000152B1 (en) | 1978-05-02 |
NL7306513A (en) | 1973-11-14 |
NL158167B (en) | 1978-10-16 |
JPS53149944A (en) | 1978-12-27 |
DE2223193A1 (en) | 1973-12-13 |
NO135707C (en) | 1977-05-16 |
HU165627B (en) | 1974-09-28 |
JPS4948624A (en) | 1974-05-11 |
FI56672B (en) | 1979-11-30 |
DE2223193B2 (en) | 1974-09-12 |
SE7602405L (en) | 1976-02-25 |
PL89241B1 (en) | 1976-11-30 |
SU501668A3 (en) | 1976-01-30 |
SE421791B (en) | 1982-02-01 |
DE2223193C3 (en) | 1975-05-28 |
NO135707B (en) | 1977-02-07 |
CA996109A (en) | 1976-08-31 |
CH579019A5 (en) | 1976-08-31 |
DK150847B (en) | 1987-07-06 |
YU123273A (en) | 1980-10-31 |
YU35572B (en) | 1981-04-30 |
JPS5726667B2 (en) | 1982-06-05 |
SE396594B (en) | 1977-09-26 |
CS179415B2 (en) | 1977-10-31 |
DK150847C (en) | 1988-01-04 |
BG22382A3 (en) | 1977-02-20 |
JPS53116339A (en) | 1978-10-11 |
RO70464A (en) | 1981-06-30 |
JPS5517020B2 (en) | 1980-05-08 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD1A | Patent lapsed |
Effective date: 19880422 |