ES399910A1 - Alkylsulfonic acid esters of 1,3,2-oxazaphospha-cyclic compounds - Google Patents
Alkylsulfonic acid esters of 1,3,2-oxazaphospha-cyclic compoundsInfo
- Publication number
- ES399910A1 ES399910A1 ES399910A ES399910A ES399910A1 ES 399910 A1 ES399910 A1 ES 399910A1 ES 399910 A ES399910 A ES 399910A ES 399910 A ES399910 A ES 399910A ES 399910 A1 ES399910 A1 ES 399910A1
- Authority
- ES
- Spain
- Prior art keywords
- formula
- same meaning
- group
- combination
- carbon atoms
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000002253 acid Substances 0.000 title abstract 3
- 150000002148 esters Chemical class 0.000 title abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 6
- 125000005843 halogen group Chemical group 0.000 abstract 6
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 5
- 125000003158 alcohol group Chemical group 0.000 abstract 3
- 125000002947 alkylene group Chemical group 0.000 abstract 3
- 229910052801 chlorine Inorganic materials 0.000 abstract 3
- 125000001309 chloro group Chemical group Cl* 0.000 abstract 3
- 125000001424 substituent group Chemical group 0.000 abstract 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- 230000001476 alcoholic effect Effects 0.000 abstract 2
- 229910052799 carbon Inorganic materials 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- BDHFUVZGWQCTTF-UHFFFAOYSA-N sulfonic acid Chemical compound OS(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-N 0.000 abstract 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- 125000004429 atom Chemical group 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 239000002184 metal Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 230000000737 periodic effect Effects 0.000 abstract 1
- 125000000542 sulfonic acid group Chemical group 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 239000011593 sulfur Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
- C07F9/6581—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms
- C07F9/6584—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms having one phosphorus atom as ring hetero atom
- C07F9/65842—Cyclic amide derivatives of acids of phosphorus, in which one nitrogen atom belongs to the ring
- C07F9/65844—Cyclic amide derivatives of acids of phosphorus, in which one nitrogen atom belongs to the ring the phosphorus atom being part of a five-membered ring which may be condensed with another ring system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
- C07F9/6581—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms
- C07F9/6584—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms having one phosphorus atom as ring hetero atom
- C07F9/65842—Cyclic amide derivatives of acids of phosphorus, in which one nitrogen atom belongs to the ring
- C07F9/65846—Cyclic amide derivatives of acids of phosphorus, in which one nitrogen atom belongs to the ring the phosphorus atom being part of a six-membered ring which may be condensed with another ring system
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Procedure for the preparation of esters of alcoholylsulfonic acid of combinations of 1, 3, 2 cycles of axasafosfa, of the general formula I **(See formula)** where R signifies a halogen atom, preferably a chlorine atom or a lower alcoholic sulfonic acid group with a straight or 1-6 carbon derived lower alcohol chain, R1, R2 signify hydrogen or a molecular lower alkylene residue with 1 -4 carbon atoms that a halogen atom can carry, preferably a chlorine atom or a group of straight chain or lower alcohol derived lower alcohol sulphonic acid, where R1 and R2 can be the same or different and the group of alcoholic acid lower sulfonic acid is found at least once in the molecule of formula I and alk means a straight-chain or derivative alkylene group with two or three carbon atoms in the chain and branching with 3 or 4 carbon atoms in total, X means oxygen or sulfur, z hydrogen or a lower alcohol group with 1-4 carbon atoms and m means 2 or 3, characterized by the fact that A) a combination of the general formula IV **(See formula)** where R3 has the same meaning as R in formula I, or is a hydroxy group, R4 has the same meaning as R1 in formula Io is a lower molecular alkylene residue with 1-4 carbon atoms, bearing a hydroxy group -, alk and X have the same meaning as in formula I and X1 is a halogen atom, preferably a chlorine atom, reacted a combination of the general formula V **(See formula)** where R5 has the same meaning as R4 in formula IV and 2 and m has the same meaning as in formula I, or B) a combination of the general formula VI **(See formula)** where R3 and R4 have the same meaning as in formula IV and alk has the same meaning as in formula I, it reacts with a combination of general formula VII **(See formula)** where X1 has the same meaning as in formula IV, R5 has the same meaning as in formula V and X, Z and m have the same meaning as in formula I or C) a combination of the general formula VIII **(See formula)** where R5 has the same meaning as in formula V and X, Z, m and alk have the same meaning as in formula I, it reacts with a combination of general formula IX **(See formula)** where R3 has the same meaning as in formula IV, and in the combinations obtained from formula X **(See formula)** in which one or more of the substituents R3, R4 and R5 are a hydroxy group or carry this group, the hydroxy groups are transformed in a manner known per se into a halogen atom or in the group -OSO2R6 where R6 is a straight or derived lower alcohol group with 1-6 carbon atoms and in combinations of formula X, in which none of the substituents R3, R4, and R5 are or carry an atom of a hydroxy group and one or more substituents R3, R4 and R5 are or carry a halogen atom, one or more of these halogen atoms is exchanged with the group -OSO2R6 by reaction for a combination of the general formula XI MeOS02R6 XI where R6 has the above meaning and Me is a metal of the first or second main or secondary group of the periodic system. (Machine-translation by Google Translate, not legally binding)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE2107936A DE2107936C3 (en) | 1971-02-19 | 1971-02-19 | Alkyl sulfonic acid esters of 2-oxo-13,2-oxazaphosphorinanes and pharmaceutical preparations containing them |
| DE19722201675 DE2201675A1 (en) | 1972-01-14 | 1972-01-14 | 1,3,2-oxaza phospha-cyclic sulphonic acid alkyl esters - - as immuno-suppressors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES399910A1 true ES399910A1 (en) | 1975-06-16 |
Family
ID=25760687
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES399910A Expired ES399910A1 (en) | 1971-02-19 | 1972-02-18 | Alkylsulfonic acid esters of 1,3,2-oxazaphospha-cyclic compounds |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US3828090A (en) |
| JP (1) | JPS5620317B1 (en) |
| AR (1) | AR195863A1 (en) |
| BE (1) | BE779516A (en) |
| CA (1) | CA957696A (en) |
| CH (3) | CH581145A5 (en) |
| DD (1) | DD94812A5 (en) |
| DK (1) | DK137013C (en) |
| ES (1) | ES399910A1 (en) |
| FI (1) | FI56387C (en) |
| FR (1) | FR2125595B1 (en) |
| HK (1) | HK11477A (en) |
| HU (1) | HU169427B (en) |
| IE (1) | IE36065B1 (en) |
| LU (1) | LU64702A1 (en) |
| MY (1) | MY7700155A (en) |
| NL (1) | NL170287C (en) |
| SE (1) | SE381464B (en) |
| YU (3) | YU38772A (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3910982A (en) * | 1971-02-19 | 1975-10-07 | Asta Werke Ag Chem Fab | Alkylsulfonic acid esters of 1,3,2-oxazaphospha-cyclic compounds |
| US4085128A (en) * | 1974-11-20 | 1978-04-18 | Shionogi & Co., Ltd. | Cyclic phosphamide derivatives |
| CN114965770B (en) * | 2022-05-24 | 2023-03-28 | 江苏海洋大学 | Method for detecting starting material, impurity D and impurity F in ifosfamide bulk drug |
-
1972
- 1972-01-31 CH CH134972A patent/CH581145A5/xx not_active IP Right Cessation
- 1972-01-31 CH CH1183575A patent/CH596231A5/xx not_active IP Right Cessation
- 1972-01-31 CH CH1183675A patent/CH586230A5/xx not_active IP Right Cessation
- 1972-02-01 LU LU64702D patent/LU64702A1/xx unknown
- 1972-02-07 IE IE147/72A patent/IE36065B1/en unknown
- 1972-02-10 US US00225273A patent/US3828090A/en not_active Expired - Lifetime
- 1972-02-16 YU YU00387/72A patent/YU38772A/en unknown
- 1972-02-17 SE SE7201916A patent/SE381464B/en unknown
- 1972-02-17 DD DD160930A patent/DD94812A5/xx unknown
- 1972-02-18 CA CA135,044A patent/CA957696A/en not_active Expired
- 1972-02-18 ES ES399910A patent/ES399910A1/en not_active Expired
- 1972-02-18 JP JP1655672A patent/JPS5620317B1/ja active Pending
- 1972-02-18 AR AR240595A patent/AR195863A1/en active
- 1972-02-18 FR FR7205549A patent/FR2125595B1/fr not_active Expired
- 1972-02-18 BE BE779516A patent/BE779516A/en not_active IP Right Cessation
- 1972-02-18 HU HUAA698A patent/HU169427B/hu unknown
- 1972-02-18 DK DK76172A patent/DK137013C/en not_active IP Right Cessation
- 1972-02-18 FI FI445/72A patent/FI56387C/en active
- 1972-02-18 NL NLAANVRAGE7202177,A patent/NL170287C/en not_active IP Right Cessation
-
1977
- 1977-03-03 HK HK114/77A patent/HK11477A/en unknown
- 1977-12-30 MY MY155/77A patent/MY7700155A/en unknown
-
1978
- 1978-10-12 YU YU2387/78A patent/YU35031B/en unknown
- 1978-10-12 YU YU2388/78A patent/YU35030B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CH586230A5 (en) | 1977-03-31 |
| HK11477A (en) | 1977-03-11 |
| AR195863A1 (en) | 1973-11-15 |
| YU238878A (en) | 1979-12-31 |
| NL170287C (en) | 1982-10-18 |
| HU169427B (en) | 1976-11-28 |
| IE36065L (en) | 1972-08-19 |
| NL7202177A (en) | 1972-08-22 |
| JPS5620317B1 (en) | 1981-05-13 |
| FI56387B (en) | 1979-09-28 |
| AU3891472A (en) | 1973-08-16 |
| YU38772A (en) | 1982-02-28 |
| FR2125595B1 (en) | 1975-03-14 |
| FR2125595A1 (en) | 1972-09-29 |
| BE779516A (en) | 1972-06-16 |
| CH581145A5 (en) | 1976-10-29 |
| YU35030B (en) | 1980-06-30 |
| LU64702A1 (en) | 1972-06-29 |
| CA957696A (en) | 1974-11-12 |
| SE381464B (en) | 1975-12-08 |
| IE36065B1 (en) | 1976-08-04 |
| NL170287B (en) | 1982-05-17 |
| FI56387C (en) | 1980-01-10 |
| DK137013C (en) | 1978-06-05 |
| YU238778A (en) | 1979-12-31 |
| YU35031B (en) | 1980-06-30 |
| DK137013B (en) | 1978-01-02 |
| DD94812A5 (en) | 1973-01-05 |
| CH596231A5 (en) | 1978-03-15 |
| MY7700155A (en) | 1977-12-31 |
| US3828090A (en) | 1974-08-06 |
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