ES399082A1 - 1,4-benzothiazepines - Google Patents
1,4-benzothiazepinesInfo
- Publication number
- ES399082A1 ES399082A1 ES399082A ES399082A ES399082A1 ES 399082 A1 ES399082 A1 ES 399082A1 ES 399082 A ES399082 A ES 399082A ES 399082 A ES399082 A ES 399082A ES 399082 A1 ES399082 A1 ES 399082A1
- Authority
- ES
- Spain
- Prior art keywords
- alkali metal
- substituted
- general formula
- salts
- lower alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D281/02—Seven-membered rings
- C07D281/04—Seven-membered rings having the hetero atoms in positions 1 and 4
- C07D281/08—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D281/10—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
A procedure for the preparation of new benzothiazepines, their salts and quaternary ammonium compounds of the general formula I **(See formula)** where A is hydrogen, a phenyl group or a substituted phenyl group, and B is OR1 or NR2R3, where R1 represents straight or branched chain lower alkyl radicals having 1 to 5 carbon atoms, which may be substituted by in turn by alkoxy, phonoxy or phenyl groups, cycloalkyl radicals or substituted phenyl group, R2 and R3, which may be the same or different, with hydrogen, hydroxyl, straight-chain or branched-chain radicals with from 1 to 5 carbon atoms, which may be substituted by amino, alkylamino, dialkylamino or phenyl groups, substituted phenyl groups, amino groups which in turn may be substituted by lower alkyl, alkylidene, acyl or aryl groups, or R2 and R3, together with the nitrogen atom to which they are attached, forms a saturated 5 or 6-membered hoterocyclic ring, which may be substituted, or A and B, together with atoms 3 and 4 of the benzothiazepine ring, form a 5-, 6- or 7-membered heterocyclic ring characterized by the fact that according to the following equation **(See formula)** thiosalicylic acid or its esters of the general formula II, where R4 signifies hydrogen or a lower alkyl group, is transformed into the corresponding alkali metal salt by the effect of alkali metal, alkali metal hydride, alkali metal alcoholate, hydroxide alkali metal, or alkali metal carbonate and imidates or amidines of the general formula III are reacted, where A and B have the above significance and Hal represents halogen or with the salts thereof having general formula III where X represents the anion of an inorganic or organic acid, in an appropriate solvent, such as water, lower alcohols, benzene, toluene, xylene, dioxane, tetrahydrofuran, dimethyl sulfoxide, etc., at temperatures of 20-150ºC, preferably at 60-80ºC, and reaction times of half an hour to several hours, and the obtained compounds are transformed into salts by means of physiologically acceptable inorganic or organic acids or in co Quaternary ammonium compounds if necessary. (Machine-translation by Google Translate, not legally binding)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE2103015 | 1971-01-22 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES399082A1 true ES399082A1 (en) | 1974-11-01 |
Family
ID=5796657
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES399082A Expired ES399082A1 (en) | 1971-01-22 | 1972-01-21 | 1,4-benzothiazepines |
Country Status (5)
Country | Link |
---|---|
AU (1) | AU3810972A (en) |
BE (1) | BE778335A (en) |
ES (1) | ES399082A1 (en) |
FR (1) | FR2122574A1 (en) |
GB (1) | GB1324755A (en) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1986000618A1 (en) * | 1984-07-13 | 1986-01-30 | Takeda Chemical Industries, Ltd. | Condensed 7-membered ring compounds and process for their preparation |
-
1972
- 1972-01-20 AU AU38109/72A patent/AU3810972A/en not_active Expired
- 1972-01-21 GB GB295072A patent/GB1324755A/en not_active Expired
- 1972-01-21 FR FR7202008A patent/FR2122574A1/fr not_active Withdrawn
- 1972-01-21 BE BE778335A patent/BE778335A/en unknown
- 1972-01-21 ES ES399082A patent/ES399082A1/en not_active Expired
Also Published As
Publication number | Publication date |
---|---|
BE778335A (en) | 1972-07-24 |
FR2122574A1 (en) | 1972-09-01 |
GB1324755A (en) | 1973-07-25 |
AU3810972A (en) | 1973-07-26 |
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