ES483304A1 - A procedure for the preparation of benzodiacepine derivatives. (Machine-translation by Google Translate, not legally binding)
- Google Patents
A procedure for the preparation of benzodiacepine derivatives. (Machine-translation by Google Translate, not legally binding)
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F Hoffmann La Roche AG
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F Hoffmann La Roche AG
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Publication of ES483304A1publicationCriticalpatent/ES483304A1/en
Pharmaceuticals Containing Other Organic And Inorganic Compounds
(AREA)
Abstract
A process for the preparation of benzodiazepine derivatives, of the general formula ** (Formula-01) ** where R1 represents a lower alkyl group, R2 represents a hydrogen atom or a lower alkyl group, R3 represents an atom of halogen and R4 represents a hydrogen or halogen atom and R5 represents a hydrogen atom and R6 represents a group of 2-hydroxyethyl, and its pharmaceutically acceptable acid addition salts, the process of which comprises hydrolytically opening the aziridine ring in a benzodiazepine derivative of the general formula ** (Formula-02) ** wherein R1, R2, R3 and R4 have the meaning indicated above in this claim, and if it is desired to convert a benzodiazepine derivative of the formula I into a salt Pharmaceutical Acceptable Acid Addition. (Machine-translation by Google Translate, not legally binding)
ES483304A1979-06-061979-08-10A procedure for the preparation of benzodiacepine derivatives. (Machine-translation by Google Translate, not legally binding)
ExpiredES483304A1
(en)
ANALOGY PROCEDURE FOR THE PREPARATION OF THERAPEUTIC ACTIVE 9-HALOGEN-7-OXO-2,3-DIHYDRO-7H-PYRIDO (1,2,3-DE) (1,4) -BENZOCSAZIN-6-CARBOXYLIC ACID COMPOUNDS.
DECAHYDROCHINOLINE DERIVATIVES, PROCESS FOR THEIR MANUFACTURE, INTERMEDIATE PRODUCTS FOR THEIR MANUFACTURE, THEIR USE AS MEDICINAL PRODUCTS AND PREPARATIONS CONTAINING THEM.