ES378825A1 - Procedure for the preparation of new cardenolidgenins. (Machine-translation by Google Translate, not legally binding) - Google Patents

Procedure for the preparation of new cardenolidgenins. (Machine-translation by Google Translate, not legally binding)

Info

Publication number
ES378825A1
ES378825A1 ES378825A ES378825A ES378825A1 ES 378825 A1 ES378825 A1 ES 378825A1 ES 378825 A ES378825 A ES 378825A ES 378825 A ES378825 A ES 378825A ES 378825 A1 ES378825 A1 ES 378825A1
Authority
ES
Spain
Prior art keywords
general formula
radical
translation
procedure
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES378825A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Pharma GmbH and Co KG
Original Assignee
Dr Karl Thomae GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dr Karl Thomae GmbH filed Critical Dr Karl Thomae GmbH
Publication of ES378825A1 publication Critical patent/ES378825A1/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A61K31/585—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin containing lactone rings, e.g. oxandrolone, bufalin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J19/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 by a lactone ring
    • E—FIXED CONSTRUCTIONS
    • E02—HYDRAULIC ENGINEERING; FOUNDATIONS; SOIL SHIFTING
    • E02D—FOUNDATIONS; EXCAVATIONS; EMBANKMENTS; UNDERGROUND OR UNDERWATER STRUCTURES
    • E02D3/00—Improving or preserving soil or rock, e.g. preserving permafrost soil
    • E02D3/02—Improving by compacting
    • E02D3/046—Improving by compacting by tamping or vibrating, e.g. with auxiliary watering of the soil
    • E02D3/074—Vibrating apparatus operating with systems involving rotary unbalanced masses
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Structural Engineering (AREA)
  • General Engineering & Computer Science (AREA)
  • Agronomy & Crop Science (AREA)
  • Civil Engineering (AREA)
  • Mining & Mineral Resources (AREA)
  • General Life Sciences & Earth Sciences (AREA)
  • Soil Sciences (AREA)
  • Environmental & Geological Engineering (AREA)
  • Paleontology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Steroid Compounds (AREA)

Abstract

Procedure for the preparation of new cardenolid-genins of the general formula wherein R1 means a hydrogen atom, an acyl radical or other easily removable protecting group, R2 means a hydrogen atom, an acyloxy group or a hydroxyl group protected by another easily removable protecting radical, and X means a fluorine atom, chlorine, an alcohol or alkoxy radical with 1 to 4 carbon atoms, characterized in that an alpha-ketol of the general formula is esterified **(See formula)** wherein R1 is as initially defined and R'2 represents a hydroxyl group and has the meanings initially indicated for R2 with a phosphonic acid of the general formula: **(See formula)** where X is as defined above and R3 represents a lower alcohol radical, and then a steroid ester obtained from the general formula is cycled **(See formula)** in which R1, R2, R3 and X are as initially defined, in the presence of a base, and from a compound of the general formula I thus obtained, they are then totally or partially separated (in position 12), optionally, the above mentioned protecting radicals, and if desired a cardenolid-genin of the general formula I is subsequently acylated. (Machine-translation by Google Translate, not legally binding)
ES378825A 1969-04-22 1970-04-20 Procedure for the preparation of new cardenolidgenins. (Machine-translation by Google Translate, not legally binding) Expired ES378825A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19691920394 DE1920394A1 (en) 1969-04-22 1969-04-22 Cardenolide-genins with positive inotropic - activity

Publications (1)

Publication Number Publication Date
ES378825A1 true ES378825A1 (en) 1973-02-01

Family

ID=5731930

Family Applications (1)

Application Number Title Priority Date Filing Date
ES378825A Expired ES378825A1 (en) 1969-04-22 1970-04-20 Procedure for the preparation of new cardenolidgenins. (Machine-translation by Google Translate, not legally binding)

Country Status (3)

Country Link
AT (1) AT301046B (en)
DE (1) DE1920394A1 (en)
ES (1) ES378825A1 (en)

Also Published As

Publication number Publication date
AT301046B (en) 1972-08-25
DE1920394A1 (en) 1970-11-19

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