ES376788A1 - Procedure for the preparation of alcanolamine derivation. (Machine-translation by Google Translate, not legally binding) - Google Patents
Procedure for the preparation of alcanolamine derivation. (Machine-translation by Google Translate, not legally binding)Info
- Publication number
- ES376788A1 ES376788A1 ES376788A ES376788A ES376788A1 ES 376788 A1 ES376788 A1 ES 376788A1 ES 376788 A ES376788 A ES 376788A ES 376788 A ES376788 A ES 376788A ES 376788 A1 ES376788 A1 ES 376788A1
- Authority
- ES
- Spain
- Prior art keywords
- radical
- formula
- chosen
- compound
- reaction
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
- C07D303/18—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by etherified hydroxyl radicals
- C07D303/20—Ethers with hydroxy compounds containing no oxirane rings
- C07D303/22—Ethers with hydroxy compounds containing no oxirane rings with monohydroxy compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C243/00—Compounds containing chains of nitrogen atoms singly-bound to each other, e.g. hydrazines, triazanes
- C07C243/24—Hydrazines having nitrogen atoms of hydrazine groups acylated by carboxylic acids
- C07C243/26—Hydrazines having nitrogen atoms of hydrazine groups acylated by carboxylic acids with acylating carboxyl groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C243/30—Hydrazines having nitrogen atoms of hydrazine groups acylated by carboxylic acids with acylating carboxyl groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of an unsaturated carbon skeleton
- C07C243/32—Hydrazines having nitrogen atoms of hydrazine groups acylated by carboxylic acids with acylating carboxyl groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of an unsaturated carbon skeleton the carbon skeleton containing rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/51—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition
- C07C45/54—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition of compounds containing doubly bound oxygen atoms, e.g. esters
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/62—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by hydrogenation of carbon-to-carbon double or triple bonds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
- C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
- C07C45/72—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction of compounds containing >C = O groups with the same or other compounds containing >C = O groups
- C07C45/74—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction of compounds containing >C = O groups with the same or other compounds containing >C = O groups combined with dehydration
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/42—Unsaturated compounds containing hydroxy or O-metal groups
- C07C59/52—Unsaturated compounds containing hydroxy or O-metal groups a hydroxy or O-metal group being bound to a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/42—Unsaturated compounds containing hydroxy or O-metal groups
- C07C59/56—Unsaturated compounds containing hydroxy or O-metal groups containing halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/04—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D263/06—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by oxygen atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
- C07D303/18—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by etherified hydroxyl radicals
- C07D303/20—Ethers with hydroxy compounds containing no oxirane rings
- C07D303/24—Ethers with hydroxy compounds containing no oxirane rings with polyhydroxy compounds
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
Procedure for the preparation of alkanolamine derivatives, of general formula: **(See formula)** wherein R1 represents a radical chosen from the group consisting of the alkyl and hydroxyalkyl radicals; A represents an alkylene radical and R2 represents a radical chosen from acyl, carbamoyl, alkylcarbamoyl, alkenylcarbamoyl and carbazoyl, or A is an alkenylene radical and R2 is chosen from acyl, cyano, alkoxycarbonyl, carbamoyl, alkylcarbamoyl, alkenylcarbamoyl and carbazoyl radicals; n represents an integer between 1 and 2; and R3, whose values can be both the same and different when n represents 2, is chosen from the group consisting of hydrogen and halogen atoms and the radicals alkyl, cycloalkyl, alkenyl, nitro, hydroxy, alkylthio, alkoxy, alkenyloxy, aryl, aryloxy, aralkyl, aralkoxy, hydroxyalkyl, alkoxyalkyl, halogenoalkyl, acyl, alkoxycarbonyl and cyano; and the esters thereof; and the aldehyde condensation products thereof, and the acid addition salts thereof, characterized in that it comprises: (a) the reaction of a member chosen from compounds of the formula: **(See formula)** in which X represents a member chosen from the group (see formula) and the group -CHOH.CH2Y, where Y represents a halogen atom, and mixtures of such compounds in which X has both meanings just manifested, with an amine of the formula NH2R1; like (b) the reaction of a member chosen from compounds of the formula: **(See formula)** and an alkali metal derivative thereof, with a compound chosen from among the formulas: (see formula) and (see formula) as well as (c) the reaction, in the presence of a base, of a compound of formula: **(See formula)** with a compound chosen from among the formulas: R2.CH2.R5 and R2.CH2-PO (OR6) 2 wherein R5 represents a member chosen from hydrogen and the carboxy radical, and R6 represents an alkyl radical of up to 6 carbon atoms, with A in the reaction product being the vinylene radical; like (d) the hydrogenolysis of a member chosen from compounds of the formula: **(See formula)** wherein R7 represents a hydrogenolizable radical, and acid addition salts thereof; like (e) the reaction under reducing conditions of a member chosen from compounds of the formula: **(See formula)** and the acid addition salts thereof, with a carbonyl compound of the formula R8.COR9, wherein R8 represents an alkyl radical and R9 represents a radical chosen from alkyl and hydroxyalkyl such that the radical R8 R9CH- has the meaning expressed for R1; after which, if desired; (f) a compound in which R2 represents a functional derivative of the carboxy radical is converted to a different compound in which R2 represents a functional derivative different from the carboxy radical; like (g) a compound in which A represents an alkenylene radical is reduced to the corresponding compound in which A represents an alkylene radical; Like (h) an alkanolamine derivative is converted to an ester thereof by reaction of an acid addition salt of the alkanolamine derivative with an acylating agent; Like (i) an alkanolamine derivative is converted to the corresponding oxazolidine derivative by reaction with an aldehyde; and after which if the alkanolamine derivative as well as its ester and its aldehyde condensation product in free base form is desired, it is converted into an acid addition salt thereof by interaction with an acid by conventional means. (Machine-translation by Google Translate, not legally binding)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB944569 | 1969-02-21 | ||
GB47048/69A GB1285038A (en) | 1969-02-21 | 1969-02-21 | Alkanolamine derivatives |
Publications (1)
Publication Number | Publication Date |
---|---|
ES376788A1 true ES376788A1 (en) | 1972-09-16 |
Family
ID=26242944
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES376788A Expired ES376788A1 (en) | 1969-02-21 | 1970-02-21 | Procedure for the preparation of alcanolamine derivation. (Machine-translation by Google Translate, not legally binding) |
Country Status (20)
Country | Link |
---|---|
JP (2) | JPS535287B1 (en) |
AT (3) | AT305249B (en) |
BE (1) | BE746107A (en) |
CA (1) | CA945172A (en) |
CH (3) | CH561175A5 (en) |
CS (3) | CS153064B2 (en) |
DE (1) | DE2007751C2 (en) |
DK (1) | DK135278B (en) |
ES (1) | ES376788A1 (en) |
FI (1) | FI53120C (en) |
FR (1) | FR2034561A1 (en) |
IE (1) | IE34003B1 (en) |
IL (1) | IL33931A (en) |
KE (1) | KE2582A (en) |
NL (1) | NL162363C (en) |
NO (1) | NO128653B (en) |
PL (3) | PL93998B1 (en) |
SE (1) | SE391517B (en) |
SU (3) | SU493062A3 (en) |
YU (4) | YU34275B (en) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1311521A (en) * | 1970-02-13 | 1973-03-28 | Ici Ltd | Alkanolamine derivatives |
DE2048838A1 (en) * | 1970-10-05 | 1972-04-06 | C H Boehnnger Sohn, 6507 Ingel heim | New 1 phenoxy 2 hydroxy 3 hydroxyal kylaminopropane and process for their manufacture |
FR2132570B1 (en) * | 1971-04-09 | 1974-08-02 | Lipha | |
GB1387630A (en) * | 1971-05-07 | 1975-03-19 | Ici Ltd | Phenoxyalkanolamine derivatives |
GB1433595A (en) * | 1972-07-06 | 1976-04-28 | Ici Ltd | Alkanolamine derivatives |
DE2623314C2 (en) * | 1976-05-25 | 1984-08-02 | Hoechst Ag, 6230 Frankfurt | 1-aryloxy-2-hydroxy-3-aminopropanes, processes for their preparation and pharmaceuticals containing them |
DE2818999A1 (en) * | 1978-04-29 | 1979-11-15 | Basf Ag | AMINO DERIVATIVES OF 3-ALKYL-5- (2-HYDROXYSTYRYL) -ISOXAZOLES |
DE2943405A1 (en) | 1979-10-26 | 1981-05-07 | Basf Ag, 6700 Ludwigshafen | NEW AMINO DERIVATIVES OF 5- (2-HYDROXYSTYRYL) -ISOXAZOLE |
US4593119A (en) * | 1980-11-28 | 1986-06-03 | American Hospital Supply Corporation | Method for treatment or prophylaxis of cardiac disorders |
US4387103A (en) * | 1980-11-28 | 1983-06-07 | American Hospital Supply Corporation | Method for treatment or prophylaxis of cardiac disorders |
JPS57105206U (en) * | 1980-12-16 | 1982-06-29 | ||
DE3407695A1 (en) * | 1984-03-02 | 1985-09-12 | Röhm Pharma GmbH, 6108 Weiterstadt | PTERIDINE COMPOUNDS WITH PHARMACEUTICAL EFFECTIVENESS |
DE3500761A1 (en) * | 1985-01-11 | 1986-09-04 | SOUR "PODRAVKA" OOUR "BELUPO 2", Proizvodnja kozmetičkih preparata i lijekova, Koprivnica | Process for the production of atenolol and its derivatives |
US4971959A (en) * | 1987-04-14 | 1990-11-20 | Warner-Lambert Company | Trisubstituted phenyl analogs having activity for congestive heart failure |
WO1994013631A1 (en) * | 1992-12-10 | 1994-06-23 | Teikoku Chemical Industries Co., Ltd. | Propionic acid derivative |
AU7261598A (en) * | 1997-04-30 | 1998-11-24 | Eli Lilly And Company | Intermediates and a process for preparing benzo{b}thiophenes |
JP5225574B2 (en) * | 2006-11-09 | 2013-07-03 | エムキュア ファーマシューティカルズ リミテッド | Improved process for the preparation of beta-blocker compounds |
WO2010079497A2 (en) | 2009-01-12 | 2010-07-15 | Hetero Research Foundation | Novel polymorph of atazanavir sulfate |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE1593762A1 (en) * | 1967-02-06 | 1972-06-08 | Boehringer Sohn Ingelheim | Process for the preparation of new substituted 1-phenoxy-2-hydroxy-3-alkylaminopropanes |
-
1970
- 1970-02-09 CA CA074,353A patent/CA945172A/en not_active Expired
- 1970-02-10 IE IE174/70A patent/IE34003B1/en unknown
- 1970-02-11 PL PL1970174445A patent/PL93998B1/en unknown
- 1970-02-11 PL PL1970174450A patent/PL87019B1/en unknown
- 1970-02-11 PL PL1970138762A patent/PL77781B1/en unknown
- 1970-02-17 BE BE746107D patent/BE746107A/en not_active IP Right Cessation
- 1970-02-18 AT AT762071A patent/AT305249B/en not_active IP Right Cessation
- 1970-02-18 CH CH1804972A patent/CH561175A5/xx not_active IP Right Cessation
- 1970-02-18 CH CH1804472A patent/CH553747A/en not_active IP Right Cessation
- 1970-02-18 AT AT761571A patent/AT305244B/en not_active IP Right Cessation
- 1970-02-18 AT AT146270A patent/AT303005B/en not_active IP Right Cessation
- 1970-02-18 CH CH232770A patent/CH547257A/en not_active IP Right Cessation
- 1970-02-19 DK DK81370AA patent/DK135278B/en unknown
- 1970-02-19 FI FI443/70A patent/FI53120C/fi active
- 1970-02-19 IL IL33931A patent/IL33931A/en unknown
- 1970-02-19 DE DE2007751A patent/DE2007751C2/en not_active Expired
- 1970-02-19 YU YU410/70A patent/YU34275B/en unknown
- 1970-02-20 SU SU1689989A patent/SU493062A3/en active
- 1970-02-20 CS CS561270*A patent/CS153064B2/en unknown
- 1970-02-20 JP JP1473970A patent/JPS535287B1/ja active Pending
- 1970-02-20 SE SE7002190A patent/SE391517B/en unknown
- 1970-02-20 CS CS561770*A patent/CS153069B2/cs unknown
- 1970-02-20 CS CS118670A patent/CS153062B2/cs unknown
- 1970-02-20 FR FR7006241A patent/FR2034561A1/en active Granted
- 1970-02-20 SU SU701404586K patent/SU482943A3/en active
- 1970-02-20 NL NL7002414.A patent/NL162363C/en not_active IP Right Cessation
- 1970-02-20 NO NO00611/70A patent/NO128653B/no unknown
- 1970-02-21 ES ES376788A patent/ES376788A1/en not_active Expired
-
1971
- 1971-08-03 SU SU1690969A patent/SU537626A3/en active
-
1973
- 1973-01-18 JP JP48008227A patent/JPS5037182B1/ja active Pending
-
1975
- 1975-06-29 YU YU1933/75A patent/YU34278B/en unknown
- 1975-07-29 YU YU1934/75A patent/YU34279B/en unknown
- 1975-07-29 YU YU1936/75A patent/YU34281B/en unknown
- 1975-11-24 KE KE2582*UA patent/KE2582A/en unknown
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