ES368909A1 - Procedure for the preparation of 9-alpha-16 - fluor-16 - metilenprednisolona or prednisona and its 21-esteres. (Machine-translation by Google Translate, not legally binding) - Google Patents

Procedure for the preparation of 9-alpha-16 - fluor-16 - metilenprednisolona or prednisona and its 21-esteres. (Machine-translation by Google Translate, not legally binding)

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Publication number
ES368909A1
ES368909A1 ES368909A ES368909A ES368909A1 ES 368909 A1 ES368909 A1 ES 368909A1 ES 368909 A ES368909 A ES 368909A ES 368909 A ES368909 A ES 368909A ES 368909 A1 ES368909 A1 ES 368909A1
Authority
ES
Spain
Prior art keywords
methylene
fluor
9alpha
translation
procedure
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES368909A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck KGaA
Original Assignee
E Merck AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by E Merck AG filed Critical E Merck AG
Priority to ES368909A priority Critical patent/ES368909A1/en
Publication of ES368909A1 publication Critical patent/ES368909A1/en
Expired legal-status Critical Current

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  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Procedure for the preparation of 9alpha-fluor-16-methylene-prednisolone or -prednisone and its 21-esters, characterized in that 9beta-11beta-oxide-l6-methylene-4-pregnen-17alpha-ol-3,20-dione it is dehydrogenated microbiologically in position 1 (2), then the 9beta, 11beta-oxide-l6-methylene-l, 4-pregnadiene-17alpha-ol-3,20-dione obtained is reacted with hydrofluoric acid and because the 9alpha-fluorine -16-methylene-l, 4-pregnadiene-11beta, -17alpha-diol-3,20-dione thus prepared is treated with iodine in alkaline solution and then with an alkaline acetate, and because in the 21-acetate of 9alpha-fluorine -6-methylene-prednisolone obtained, the group 11-oh is optionally transformed by treatment with an oxidizing agent in a group 11-keto and/or the group 21-acetoxy is saponified by treatment with a saponification agent under formation of 9alpha -fluor-l6-methylene-prednisolone or-prednisone as well as eventually these compounds are transformed by treatment with an agent esterification in its 21-esters. (Machine-translation by Google Translate, not legally binding)
ES368909A 1969-06-28 1969-06-28 Procedure for the preparation of 9-alpha-16 - fluor-16 - metilenprednisolona or prednisona and its 21-esteres. (Machine-translation by Google Translate, not legally binding) Expired ES368909A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
ES368909A ES368909A1 (en) 1969-06-28 1969-06-28 Procedure for the preparation of 9-alpha-16 - fluor-16 - metilenprednisolona or prednisona and its 21-esteres. (Machine-translation by Google Translate, not legally binding)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES368909A ES368909A1 (en) 1969-06-28 1969-06-28 Procedure for the preparation of 9-alpha-16 - fluor-16 - metilenprednisolona or prednisona and its 21-esteres. (Machine-translation by Google Translate, not legally binding)

Publications (1)

Publication Number Publication Date
ES368909A1 true ES368909A1 (en) 1971-05-01

Family

ID=8453234

Family Applications (1)

Application Number Title Priority Date Filing Date
ES368909A Expired ES368909A1 (en) 1969-06-28 1969-06-28 Procedure for the preparation of 9-alpha-16 - fluor-16 - metilenprednisolona or prednisona and its 21-esteres. (Machine-translation by Google Translate, not legally binding)

Country Status (1)

Country Link
ES (1) ES368909A1 (en)

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