ES358955A1 - Procedimiento para la produccion de nuevos compuestos orga-nicos relacionados estructuralmente con las prostaglandinas. - Google Patents
Procedimiento para la produccion de nuevos compuestos orga-nicos relacionados estructuralmente con las prostaglandinas.Info
- Publication number
- ES358955A1 ES358955A1 ES358955A ES358955A ES358955A1 ES 358955 A1 ES358955 A1 ES 358955A1 ES 358955 A ES358955 A ES 358955A ES 358955 A ES358955 A ES 358955A ES 358955 A1 ES358955 A1 ES 358955A1
- Authority
- ES
- Spain
- Prior art keywords
- compounds
- iii
- cis
- trans
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- -1 Prostaglandin e primary alcohols Chemical class 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 4
- IOVCWXUNBOPUCH-UHFFFAOYSA-N Nitrous acid Chemical compound ON=O IOVCWXUNBOPUCH-UHFFFAOYSA-N 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- UCTWMZQNUQWSLP-VIFPVBQESA-N (R)-adrenaline Chemical compound CNC[C@H](O)C1=CC=C(O)C(O)=C1 UCTWMZQNUQWSLP-VIFPVBQESA-N 0.000 abstract 1
- 229930182837 (R)-adrenaline Natural products 0.000 abstract 1
- AVXURJPOCDRRFD-UHFFFAOYSA-N Hydroxylamine Chemical compound ON AVXURJPOCDRRFD-UHFFFAOYSA-N 0.000 abstract 1
- 239000012448 Lithium borohydride Substances 0.000 abstract 1
- 208000007536 Thrombosis Diseases 0.000 abstract 1
- 239000005557 antagonist Substances 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 210000001772 blood platelet Anatomy 0.000 abstract 1
- 150000001735 carboxylic acids Chemical class 0.000 abstract 1
- 239000000969 carrier Substances 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 239000003153 chemical reaction reagent Substances 0.000 abstract 1
- SIPUZPBQZHNSDW-UHFFFAOYSA-N diisobutylaluminium hydride Substances CC(C)C[Al]CC(C)C SIPUZPBQZHNSDW-UHFFFAOYSA-N 0.000 abstract 1
- 229960005139 epinephrine Drugs 0.000 abstract 1
- 235000021588 free fatty acids Nutrition 0.000 abstract 1
- 230000007062 hydrolysis Effects 0.000 abstract 1
- 238000006460 hydrolysis reaction Methods 0.000 abstract 1
- 238000011065 in-situ storage Methods 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 239000012280 lithium aluminium hydride Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 125000004043 oxo group Chemical group O=* 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 208000010110 spontaneous platelet aggregation Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
- C07C405/0008—Analogues having the carboxyl group in the side-chains replaced by other functional groups
- C07C405/0041—Analogues having the carboxyl group in the side-chains replaced by other functional groups containing nitrogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
- C07C405/0008—Analogues having the carboxyl group in the side-chains replaced by other functional groups
- C07C405/0025—Analogues having the carboxyl group in the side-chains replaced by other functional groups containing keto groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US67397967A | 1967-10-09 | 1967-10-09 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES358955A1 true ES358955A1 (es) | 1970-05-16 |
Family
ID=24704856
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES358955A Expired ES358955A1 (es) | 1967-10-09 | 1968-10-08 | Procedimiento para la produccion de nuevos compuestos orga-nicos relacionados estructuralmente con las prostaglandinas. |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US3636120A (es) |
| BE (1) | BE722031A (es) |
| BR (1) | BR6802950D0 (es) |
| CH (1) | CH515868A (es) |
| DE (1) | DE1801750C3 (es) |
| ES (1) | ES358955A1 (es) |
| FR (1) | FR1594643A (es) |
| GB (1) | GB1172200A (es) |
| IL (1) | IL30797A (es) |
| NL (1) | NL6814426A (es) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3953435A (en) * | 1974-01-10 | 1976-04-27 | Ono Pharmaceutical Company | Aldehyde derivatives of prostaglandins |
| US4022912A (en) * | 1976-02-09 | 1977-05-10 | Miles Laboratories, Inc. | Use of 1-decarboxy-1-hydroxymethyl-PGE1 in therapeutic bronchodilation |
| US4158018A (en) * | 1978-09-12 | 1979-06-12 | Miles Laboratories, Inc. | 3-Oxa carbinol prostaglandin analogs |
| US5807895A (en) * | 1994-11-29 | 1998-09-15 | Schwarz Pharma, Inc. | Use of prostaglandin E1, E2 or analogs to prevent renal failure induced by medical tests that utilize contrast media agents |
| ID26699A (id) | 1998-03-31 | 2001-02-01 | Procter & Gamble | Prostaglandin c11 oksimil dan hidroksilamino yang berguna sebagai obat |
| US6444840B1 (en) | 1998-03-31 | 2002-09-03 | The Procter & Gamble Co. | C11 oxymyl and hydroxylamino prostaglandins useful as FP agonists |
| EP1159266B1 (en) | 1999-03-05 | 2004-11-03 | Duke University | C-16 unsaturated fp-selective prostaglandins analogs |
| US20020013294A1 (en) | 2000-03-31 | 2002-01-31 | Delong Mitchell Anthony | Cosmetic and pharmaceutical compositions and methods using 2-decarboxy-2-phosphinico derivatives |
| US20020146439A1 (en) * | 2000-03-31 | 2002-10-10 | Delong Mitchell Anthony | Compositions and methods for treating hair loss using oximyl and hydroxylamino prostaglandins |
| US20020172693A1 (en) | 2000-03-31 | 2002-11-21 | Delong Michell Anthony | Compositions and methods for treating hair loss using non-naturally occurring prostaglandins |
| US20020037914A1 (en) * | 2000-03-31 | 2002-03-28 | Delong Mitchell Anthony | Compositions and methods for treating hair loss using C16-C20 aromatic tetrahydro prostaglandins |
| US8623918B2 (en) * | 2008-10-29 | 2014-01-07 | Novaer Holdings, Inc. | Amino acid salts of prostaglandins |
| US8722739B2 (en) * | 2008-10-29 | 2014-05-13 | Novaer Holdings, Inc. | Amino acid salts of prostaglandins |
-
1967
- 1967-10-09 US US673979A patent/US3636120A/en not_active Expired - Lifetime
-
1968
- 1968-10-01 IL IL30797A patent/IL30797A/en unknown
- 1968-10-03 CH CH1477568A patent/CH515868A/de not_active IP Right Cessation
- 1968-10-08 FR FR1594643D patent/FR1594643A/fr not_active Expired
- 1968-10-08 BR BR202950/68A patent/BR6802950D0/pt unknown
- 1968-10-08 DE DE1801750A patent/DE1801750C3/de not_active Expired
- 1968-10-08 ES ES358955A patent/ES358955A1/es not_active Expired
- 1968-10-09 GB GB47885/68A patent/GB1172200A/en not_active Expired
- 1968-10-09 NL NL6814426A patent/NL6814426A/xx not_active Application Discontinuation
- 1968-10-09 BE BE722031D patent/BE722031A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DE1801750A1 (de) | 1969-07-10 |
| NL6814426A (es) | 1969-04-11 |
| FR1594643A (es) | 1970-06-08 |
| US3636120A (en) | 1972-01-18 |
| BE722031A (es) | 1969-04-09 |
| CH515868A (de) | 1971-11-30 |
| DE1801750B2 (de) | 1980-05-14 |
| DE1801750C3 (de) | 1981-02-12 |
| IL30797A0 (en) | 1968-12-26 |
| IL30797A (en) | 1972-07-26 |
| BR6802950D0 (pt) | 1973-02-22 |
| GB1172200A (en) | 1969-11-26 |
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