ES357107A1 - Benzenesulphonyl-Ureas and Process for Preparing Them - Google Patents
Benzenesulphonyl-Ureas and Process for Preparing ThemInfo
- Publication number
- ES357107A1 ES357107A1 ES357107A ES357107A ES357107A1 ES 357107 A1 ES357107 A1 ES 357107A1 ES 357107 A ES357107 A ES 357107A ES 357107 A ES357107 A ES 357107A ES 357107 A1 ES357107 A1 ES 357107A1
- Authority
- ES
- Spain
- Prior art keywords
- alkoxy
- cyclopentyl
- bicyclo
- signifies
- methyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
- C07D333/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D333/70—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 2
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Novel benzenesulphonyl - ureas (including salts thereof) of the general formula wherein R1 signifies 4,7-endomethylene-perhydroindan-5-yl which may be substituted by chlorine at the 6-position, 4,7-endomethyleneperhydroindan - 2 - yl, 2,6 - endomethylenecycloheptyl, 4,4 - dimethyl #2 - cyclohexenyl, #2 - cyclopentenyl, -heptenyl or -octenyl, norcaran-7-yl, bicyclo-[5,1,0]-octyl-(8), bicyclo- [6,10] - nonyl - (9), bicyclo - [4,2,0] - octyl - (7), 2,5 - endo - cyclobutylene - (1,2) - cyclohexyl, methyl - cyclopentyl, 3,3 - dimethyl - cyclopentyl, 3 - ethyl cyclopentyl, 3 - tert. - butylcyclopentyl, 2 - chloro - cyclopentyl, #2 - cyclopentenyl - methyl, bicyclo - [2,1,1] - hexyl - (2), spiro - (2 - cyclopropane - cyclopentyl), spiro- (2 - cyclobutane - cyclopentyl), spiro - (2 - cyclopentane - cyclopentyl), cyclopropyl, cyclobutyl, 5 - methyl - #2 - cyclohexenyl, or bicyclo - [3,1,0] - hexyl, X represents (a) a phenyl group carrying at any desired position the substituents Z and Z1 which may be the same or different and wherein Z signifies hydrogen, halogen, alkyl, alkoxy, alkenoxy, alkoxyalkoxy, phenalkoxy, acyl, benzoyl, CF 3 or OH and Z1 signifies CN, NO 2 , hydrogen, halogen, alkyl, alkoxy, alkoxy-alkoxy, or OH or (b) a thiophene group which may be substituted by one or two substituents selected from alkyl, alkoxy, alkoxy-alkoxy, alkenoxy, phenalkoxy radicals and halogen atoms, and Y signifies -CH 2 .CH 2 .-, -CH 2 .CH.Me- or -CH.Me.CH 2 - are obtained according to Standard methods. 5 Amino - 4,7 - endomethylene - perhydroindane is prepared by hydrogenating dicyclopentadiene-bis-nitroso-chloride. N - [4 - (# - <2 - Methoxy - 5 - chloro - benzamido> - ethyl) - benzenesulphonyl] - N1 - (4,7- endomethylene - perhydroindanyl - 5) - isourea methyl ether is obtained by treating the corresponding thiourea with mercury oxide in the presence of methanol and dioxane. Pharmaceutical preparations showing hypoglycaemic activity contain as active ingredient the above novel compounds administration is, e.g. in the form of a tablet or powder.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DEF0053202 | 1967-08-10 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES357107A1 true ES357107A1 (en) | 1970-03-01 |
Family
ID=7106084
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES357107A Expired ES357107A1 (en) | 1967-08-10 | 1968-08-09 | Benzenesulphonyl-Ureas and Process for Preparing Them |
Country Status (21)
| Country | Link |
|---|---|
| AR (4) | AR193491A1 (en) |
| AT (2) | AT321316B (en) |
| CH (5) | CH506500A (en) |
| CY (1) | CY585A (en) |
| DK (1) | DK132946C (en) |
| ES (1) | ES357107A1 (en) |
| FI (1) | FI50115C (en) |
| FR (2) | FR1598160A (en) |
| GB (1) | GB1194790A (en) |
| IL (1) | IL30431A (en) |
| IS (1) | IS767B6 (en) |
| IT (1) | IT1053691B (en) |
| LU (1) | LU56488A1 (en) |
| MC (1) | MC725A1 (en) |
| MY (1) | MY7100109A (en) |
| NL (1) | NL163778C (en) |
| NO (1) | NO126685B (en) |
| OA (1) | OA02877A (en) |
| PL (1) | PL84736B1 (en) |
| SE (1) | SE352345B (en) |
| SU (4) | SU399115A3 (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE791638A (en) * | 1971-11-20 | 1973-05-21 | Hoechst Ag | SULFONYL-UREES, THEIR PREPARATION PROCESS AND THEIR APPLICATIONS |
| DK455480A (en) * | 1979-11-30 | 1981-05-31 | Du Pont | METHOD OF PREPARING HERBICIDE N- (SUBSTITUTED HETEROCYCLIC AMINOCARBONYL) -AROMATIC SULPHONAMIDES |
-
1968
- 1968-07-15 AT AT308073A patent/AT321316B/en not_active IP Right Cessation
- 1968-07-15 AT AT06800/68A patent/AT319263B/en not_active IP Right Cessation
- 1968-07-15 LU LU56488D patent/LU56488A1/xx unknown
- 1968-07-16 FI FI682028A patent/FI50115C/en active
- 1968-07-16 CH CH1062168A patent/CH506500A/en not_active IP Right Cessation
- 1968-07-16 NO NO02818/68A patent/NO126685B/no unknown
- 1968-07-16 CH CH33871A patent/CH522609A/en not_active IP Right Cessation
- 1968-07-16 CH CH33971A patent/CH522610A/en not_active IP Right Cessation
- 1968-07-16 CH CH371472A patent/CH522615A/en not_active IP Right Cessation
- 1968-07-16 CH CH371372A patent/CH522614A/en not_active IP Right Cessation
- 1968-07-17 SE SE09781/68A patent/SE352345B/xx unknown
- 1968-07-25 IL IL30431A patent/IL30431A/en unknown
- 1968-08-05 PL PL1968128491A patent/PL84736B1/en unknown
- 1968-08-08 NL NL6811279.A patent/NL163778C/en active
- 1968-08-09 IT IT20028/68A patent/IT1053691B/en active
- 1968-08-09 IS IS1759A patent/IS767B6/en unknown
- 1968-08-09 OA OA53352A patent/OA02877A/en unknown
- 1968-08-09 MC MC771A patent/MC725A1/en unknown
- 1968-08-09 ES ES357107A patent/ES357107A1/en not_active Expired
- 1968-08-09 DK DK386868A patent/DK132946C/en active
- 1968-08-10 SU SU1650165A patent/SU399115A3/ru active
- 1968-08-10 SU SU1615146A patent/SU400086A3/ru active
- 1968-08-10 SU SU1615624A patent/SU460622A3/en active
- 1968-08-10 SU SU1647219A patent/SU404232A3/ru active
- 1968-08-12 FR FR1598160D patent/FR1598160A/fr not_active Expired
- 1968-08-12 GB GB38468/68A patent/GB1194790A/en not_active Expired
- 1968-11-08 FR FR173083A patent/FR8094M/fr not_active Expired
-
1969
- 1969-12-02 AR AR225660A patent/AR193491A1/en active
- 1969-12-02 AR AR225656A patent/AR192552A1/en active
- 1969-12-02 AR AR225658A patent/AR193338A1/en active
-
1971
- 1971-04-22 CY CY58571A patent/CY585A/en unknown
- 1971-08-13 AR AR237385A patent/AR196978A1/en active
- 1971-12-31 MY MY1971109A patent/MY7100109A/en unknown
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