ES338882A1 - Novel Gona-4,9,11-trienes, Processes for their Preparation, and Compositions incorporating them - Google Patents
Novel Gona-4,9,11-trienes, Processes for their Preparation, and Compositions incorporating themInfo
- Publication number
- ES338882A1 ES338882A1 ES338882A ES338882A ES338882A1 ES 338882 A1 ES338882 A1 ES 338882A1 ES 338882 A ES338882 A ES 338882A ES 338882 A ES338882 A ES 338882A ES 338882 A1 ES338882 A1 ES 338882A1
- Authority
- ES
- Spain
- Prior art keywords
- estra
- trien
- novel
- ones
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
- A61K31/567—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in position 17 alpha, e.g. mestranol, norethandrolone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
- A61K31/568—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone
- A61K31/569—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone substituted in position 17 alpha, e.g. ethisterone
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J75/00—Processes for the preparation of steroids in general
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
Abstract
Novel compounds of formula (wherein A is an oxo or ketal group, B is alkyl, D is H or optionally substituted alkyl, E is an optionally substituted hydrocarbon or heterocyclic radical), and derivatives thereof containing one or more additional nuclear substituents, are prepared by etherification of the corresponding 17#-ols. The compounds 17#-methoxy- 17[alpha] - methyl - estra - 4,9,11 - trien - 3 - one (see Specification 1,127,746) and 17#-tetrahydropyranyloxy - estra - 4,9,11 - trien - 3 - one (see Specification 1,099,006) are disclaimed. The 3- ketals of Formula I may be converted to the 3- ones by hydrolysis. The novel 3-ketals of 17#-hydroxy-estra-4,9, 11 - trien - 3 - one and of 17[alpha] - methyl - 17#- hydroxy - estra - 4,9,11 - trien - 3 - one are prepared by reduction of the corresponding 17- ones or by ketalization of the corresponding 3-ones. The compounds of Formula I are stated to possess anabolizing and androgenic activities and may be made up with suitable vehicles into pharmaceutical compositions which may be administered orally, parenterally, rectally or topically.
Applications Claiming Priority (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR46778 | 1966-01-21 | ||
FR56491A FR5301M (en) | 1966-01-21 | 1966-04-05 | |
FR58471A FR5320M (en) | 1966-01-21 | 1966-04-21 | |
FR61569A FR5484M (en) | 1966-01-21 | 1966-05-13 | |
FR68757A FR1492985A (en) | 1966-01-21 | 1966-07-08 | unsaturated steroid ethers and methods of preparation |
FR85819A FR6425M (en) | 1966-01-21 | 1966-12-01 | |
FR95053A FR6096M (en) | 1966-01-21 | 1967-02-15 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES338882A1 true ES338882A1 (en) | 1968-04-16 |
Family
ID=27562279
Family Applications (5)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES338882A Expired ES338882A1 (en) | 1966-01-21 | 1967-04-04 | Novel Gona-4,9,11-trienes, Processes for their Preparation, and Compositions incorporating them |
ES340433A Expired ES340433A1 (en) | 1966-01-21 | 1967-05-12 | Novel Gona-4,9,11-trienes, Processes for their Preparation, and Compositions incorporating them |
ES342740A Expired ES342740A1 (en) | 1966-01-21 | 1967-07-07 | Novel Gona-4,9,11-trienes, Processes for their Preparation, and Compositions incorporating them |
ES347368A Expired ES347368A1 (en) | 1966-01-21 | 1967-11-20 | Novel Gona-4,9,11-trienes, Processes for their Preparation, and Compositions incorporating them |
ES350471A Expired ES350471A2 (en) | 1966-01-21 | 1968-02-14 | Novel Gona-4,9,11-trienes, Processes for their Preparation, and Compositions incorporating them |
Family Applications After (4)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES340433A Expired ES340433A1 (en) | 1966-01-21 | 1967-05-12 | Novel Gona-4,9,11-trienes, Processes for their Preparation, and Compositions incorporating them |
ES342740A Expired ES342740A1 (en) | 1966-01-21 | 1967-07-07 | Novel Gona-4,9,11-trienes, Processes for their Preparation, and Compositions incorporating them |
ES347368A Expired ES347368A1 (en) | 1966-01-21 | 1967-11-20 | Novel Gona-4,9,11-trienes, Processes for their Preparation, and Compositions incorporating them |
ES350471A Expired ES350471A2 (en) | 1966-01-21 | 1968-02-14 | Novel Gona-4,9,11-trienes, Processes for their Preparation, and Compositions incorporating them |
Country Status (10)
Country | Link |
---|---|
AT (1) | AT280493B (en) |
BE (1) | BE696084A (en) |
CH (1) | CH474499A (en) |
DK (1) | DK120949B (en) |
ES (5) | ES338882A1 (en) |
FR (6) | FR5301M (en) |
GB (1) | GB1175456A (en) |
IL (1) | IL27745A (en) |
NL (1) | NL6704829A (en) |
SE (1) | SE320364B (en) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2183555B1 (en) * | 1972-05-10 | 1975-06-20 | Roussel Uclaf | |
FR2285138A1 (en) * | 1974-09-20 | 1976-04-16 | Roussel Uclaf | NEW TRIENIC STEROID DERIVATIVE, ITS PREPARATION PROCESS AND ITS APPLICATION AS A MEDICINAL PRODUCT |
FR2388560A1 (en) * | 1977-04-27 | 1978-11-24 | Roussel Uclaf | NEW ZOOTECHNICAL COMPOSITIONS CONTAINING ON THE ONE HAND ZERANOL AND ON THE OTHER HAND A STEROID 4,9,11 TRIENIQUE |
-
1966
- 1966-04-05 FR FR56491A patent/FR5301M/fr not_active Expired
- 1966-04-21 FR FR58471A patent/FR5320M/fr not_active Expired
- 1966-05-13 FR FR61569A patent/FR5484M/fr not_active Expired
- 1966-07-08 FR FR68757A patent/FR1492985A/en not_active Expired
- 1966-12-01 FR FR85819A patent/FR6425M/fr not_active Expired
-
1967
- 1967-02-15 FR FR95053A patent/FR6096M/fr not_active Expired
- 1967-03-24 BE BE696084D patent/BE696084A/xx unknown
- 1967-03-30 DK DK168367A patent/DK120949B/en unknown
- 1967-03-30 CH CH446467A patent/CH474499A/en not_active IP Right Cessation
- 1967-04-03 SE SE461967A patent/SE320364B/xx unknown
- 1967-04-04 ES ES338882A patent/ES338882A1/en not_active Expired
- 1967-04-05 IL IL2774567A patent/IL27745A/en unknown
- 1967-04-05 NL NL6704829A patent/NL6704829A/xx unknown
- 1967-04-05 AT AT326267A patent/AT280493B/en not_active IP Right Cessation
- 1967-04-05 GB GB05571/67A patent/GB1175456A/en not_active Expired
- 1967-05-12 ES ES340433A patent/ES340433A1/en not_active Expired
- 1967-07-07 ES ES342740A patent/ES342740A1/en not_active Expired
- 1967-11-20 ES ES347368A patent/ES347368A1/en not_active Expired
-
1968
- 1968-02-14 ES ES350471A patent/ES350471A2/en not_active Expired
Also Published As
Publication number | Publication date |
---|---|
ES342740A1 (en) | 1968-08-01 |
FR6425M (en) | 1968-11-04 |
SE320364B (en) | 1970-02-09 |
NL6704829A (en) | 1967-10-06 |
FR5320M (en) | 1967-08-21 |
ES340433A1 (en) | 1968-06-01 |
FR5301M (en) | 1967-08-16 |
FR1492985A (en) | 1967-08-25 |
DK120949B (en) | 1971-08-09 |
AT280493B (en) | 1970-04-10 |
GB1175456A (en) | 1969-12-23 |
BE696084A (en) | 1967-09-25 |
IL27745A (en) | 1974-10-22 |
FR5484M (en) | 1967-10-23 |
ES350471A2 (en) | 1969-05-01 |
FR6096M (en) | 1968-06-10 |
ES347368A1 (en) | 1969-02-01 |
CH474499A (en) | 1969-06-30 |
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