ES338882A1 - Novel Gona-4,9,11-trienes, Processes for their Preparation, and Compositions incorporating them - Google Patents

Novel Gona-4,9,11-trienes, Processes for their Preparation, and Compositions incorporating them

Info

Publication number
ES338882A1
ES338882A1 ES338882A ES338882A ES338882A1 ES 338882 A1 ES338882 A1 ES 338882A1 ES 338882 A ES338882 A ES 338882A ES 338882 A ES338882 A ES 338882A ES 338882 A1 ES338882 A1 ES 338882A1
Authority
ES
Spain
Prior art keywords
estra
trien
novel
ones
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES338882A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Roussel Uclaf SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roussel Uclaf SA filed Critical Roussel Uclaf SA
Publication of ES338882A1 publication Critical patent/ES338882A1/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A61K31/567—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in position 17 alpha, e.g. mestranol, norethandrolone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A61K31/568—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone
    • A61K31/569—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone substituted in position 17 alpha, e.g. ethisterone
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J75/00—Processes for the preparation of steroids in general

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)

Abstract

Novel compounds of formula (wherein A is an oxo or ketal group, B is alkyl, D is H or optionally substituted alkyl, E is an optionally substituted hydrocarbon or heterocyclic radical), and derivatives thereof containing one or more additional nuclear substituents, are prepared by etherification of the corresponding 17#-ols. The compounds 17#-methoxy- 17[alpha] - methyl - estra - 4,9,11 - trien - 3 - one (see Specification 1,127,746) and 17#-tetrahydropyranyloxy - estra - 4,9,11 - trien - 3 - one (see Specification 1,099,006) are disclaimed. The 3- ketals of Formula I may be converted to the 3- ones by hydrolysis. The novel 3-ketals of 17#-hydroxy-estra-4,9, 11 - trien - 3 - one and of 17[alpha] - methyl - 17#- hydroxy - estra - 4,9,11 - trien - 3 - one are prepared by reduction of the corresponding 17- ones or by ketalization of the corresponding 3-ones. The compounds of Formula I are stated to possess anabolizing and androgenic activities and may be made up with suitable vehicles into pharmaceutical compositions which may be administered orally, parenterally, rectally or topically.
ES338882A 1966-01-21 1967-04-04 Novel Gona-4,9,11-trienes, Processes for their Preparation, and Compositions incorporating them Expired ES338882A1 (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
FR46778 1966-01-21
FR56491A FR5301M (en) 1966-01-21 1966-04-05
FR58471A FR5320M (en) 1966-01-21 1966-04-21
FR61569A FR5484M (en) 1966-01-21 1966-05-13
FR68757A FR1492985A (en) 1966-01-21 1966-07-08 unsaturated steroid ethers and methods of preparation
FR85819A FR6425M (en) 1966-01-21 1966-12-01
FR95053A FR6096M (en) 1966-01-21 1967-02-15

Publications (1)

Publication Number Publication Date
ES338882A1 true ES338882A1 (en) 1968-04-16

Family

ID=27562279

Family Applications (5)

Application Number Title Priority Date Filing Date
ES338882A Expired ES338882A1 (en) 1966-01-21 1967-04-04 Novel Gona-4,9,11-trienes, Processes for their Preparation, and Compositions incorporating them
ES340433A Expired ES340433A1 (en) 1966-01-21 1967-05-12 Novel Gona-4,9,11-trienes, Processes for their Preparation, and Compositions incorporating them
ES342740A Expired ES342740A1 (en) 1966-01-21 1967-07-07 Novel Gona-4,9,11-trienes, Processes for their Preparation, and Compositions incorporating them
ES347368A Expired ES347368A1 (en) 1966-01-21 1967-11-20 Novel Gona-4,9,11-trienes, Processes for their Preparation, and Compositions incorporating them
ES350471A Expired ES350471A2 (en) 1966-01-21 1968-02-14 Novel Gona-4,9,11-trienes, Processes for their Preparation, and Compositions incorporating them

Family Applications After (4)

Application Number Title Priority Date Filing Date
ES340433A Expired ES340433A1 (en) 1966-01-21 1967-05-12 Novel Gona-4,9,11-trienes, Processes for their Preparation, and Compositions incorporating them
ES342740A Expired ES342740A1 (en) 1966-01-21 1967-07-07 Novel Gona-4,9,11-trienes, Processes for their Preparation, and Compositions incorporating them
ES347368A Expired ES347368A1 (en) 1966-01-21 1967-11-20 Novel Gona-4,9,11-trienes, Processes for their Preparation, and Compositions incorporating them
ES350471A Expired ES350471A2 (en) 1966-01-21 1968-02-14 Novel Gona-4,9,11-trienes, Processes for their Preparation, and Compositions incorporating them

Country Status (10)

Country Link
AT (1) AT280493B (en)
BE (1) BE696084A (en)
CH (1) CH474499A (en)
DK (1) DK120949B (en)
ES (5) ES338882A1 (en)
FR (6) FR5301M (en)
GB (1) GB1175456A (en)
IL (1) IL27745A (en)
NL (1) NL6704829A (en)
SE (1) SE320364B (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2183555B1 (en) * 1972-05-10 1975-06-20 Roussel Uclaf
FR2285138A1 (en) * 1974-09-20 1976-04-16 Roussel Uclaf NEW TRIENIC STEROID DERIVATIVE, ITS PREPARATION PROCESS AND ITS APPLICATION AS A MEDICINAL PRODUCT
FR2388560A1 (en) * 1977-04-27 1978-11-24 Roussel Uclaf NEW ZOOTECHNICAL COMPOSITIONS CONTAINING ON THE ONE HAND ZERANOL AND ON THE OTHER HAND A STEROID 4,9,11 TRIENIQUE

Also Published As

Publication number Publication date
ES342740A1 (en) 1968-08-01
FR6425M (en) 1968-11-04
SE320364B (en) 1970-02-09
NL6704829A (en) 1967-10-06
FR5320M (en) 1967-08-21
ES340433A1 (en) 1968-06-01
FR5301M (en) 1967-08-16
FR1492985A (en) 1967-08-25
DK120949B (en) 1971-08-09
AT280493B (en) 1970-04-10
GB1175456A (en) 1969-12-23
BE696084A (en) 1967-09-25
IL27745A (en) 1974-10-22
FR5484M (en) 1967-10-23
ES350471A2 (en) 1969-05-01
FR6096M (en) 1968-06-10
ES347368A1 (en) 1969-02-01
CH474499A (en) 1969-06-30

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