GB1269531A - Improvements in or relating to gem-difluoro steroid derivatives - Google Patents
Improvements in or relating to gem-difluoro steroid derivativesInfo
- Publication number
- GB1269531A GB1269531A GB1509169A GB1509169A GB1269531A GB 1269531 A GB1269531 A GB 1269531A GB 1509169 A GB1509169 A GB 1509169A GB 1509169 A GB1509169 A GB 1509169A GB 1269531 A GB1269531 A GB 1269531A
- Authority
- GB
- United Kingdom
- Prior art keywords
- alkyl
- group
- aryl
- steroids
- esterified
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J75/00—Processes for the preparation of steroids in general
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Steroid Compounds (AREA)
Abstract
1,269,531. 6,6-Difluoro steroids. SYNTEX CORP. 21 March, 1969, No. 15091/69. Addition to 1,248,938. Heading C2U. The invention comprises compounds of formula wherein R<SP>1</SP> is F or Cl; R<SP>2</SP> is H or a free, esterified or etherified hydroxy group; R<SP>3</SP> is H, OH or Me, with the proviso that R<SP>3</SP> is Me when R<SP>1</SP> is F and R<SP>2</SP> is H or a free or esterified hydroxy group; or R<SP>2</SP> and R<SP>3</SP> together represent the group wherein R<SP>4</SP> and <SP>R6</SP> each represent H, C 1-6 alkyl, C 1-6 haloalkyl, C 3-6 cycloalkyl (C 3-6 cycloalkyl)- (C 1-6 alkyl), " aryl," " aryl "-(C 1-6 alkyl), monocyclic heterocyclyl or (monocyclic heterocyclyl)- (C 1-6 alkyl), or R<SP>4</SP> and R<SP>5</SP> together with the intervening carbon atom represent an optionally esterified or salified (C 2-8 carboxyalkylidene) group, or a monocyclic cycloalkylidene or monocyclic heterocyclic ylidene group; and Z is a single or double carbon-carbon bond. The term " aryl " signifies phenyl optionally substituted with 1-3 F, Cl, OH, C 1-6 alkyl, C 1-6 alkoxy or acylamino groups. Any heterocyclic radicals have 5 or 6 ring atoms including 1 or 2 O, N or S atoms. Preparation of the above is from the corresponding #<SP>4</SP> - 6(α or #) - monofluoro steroids by enol etherification to 3 - alkoxy - #<SP>3,5</SP> - 6 - fluoro steroids which are then treated with perchloryl fluoride to yield the #<SP>4</SP> inventive compounds which may then be dehydrogenated. The compounds of Formula I are said to possess progestational activity, and may be made up with carriers into pharmaceutical compositions for oral and parenteral administration.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB1509169A GB1269531A (en) | 1969-03-21 | 1969-03-21 | Improvements in or relating to gem-difluoro steroid derivatives |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB1509169A GB1269531A (en) | 1969-03-21 | 1969-03-21 | Improvements in or relating to gem-difluoro steroid derivatives |
Publications (1)
Publication Number | Publication Date |
---|---|
GB1269531A true GB1269531A (en) | 1972-04-06 |
Family
ID=10052872
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB1509169A Expired GB1269531A (en) | 1969-03-21 | 1969-03-21 | Improvements in or relating to gem-difluoro steroid derivatives |
Country Status (1)
Country | Link |
---|---|
GB (1) | GB1269531A (en) |
-
1969
- 1969-03-21 GB GB1509169A patent/GB1269531A/en not_active Expired
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