ES320302A1 - A procedure for the preparation of benzodiazepine derivatives. (Machine-translation by Google Translate, not legally binding) - Google Patents
A procedure for the preparation of benzodiazepine derivatives. (Machine-translation by Google Translate, not legally binding)Info
- Publication number
- ES320302A1 ES320302A1 ES0320302A ES320302A ES320302A1 ES 320302 A1 ES320302 A1 ES 320302A1 ES 0320302 A ES0320302 A ES 0320302A ES 320302 A ES320302 A ES 320302A ES 320302 A1 ES320302 A1 ES 320302A1
- Authority
- ES
- Spain
- Prior art keywords
- general formula
- see formula
- represents hydrogen
- compound
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
A process for the preparation of benzodiazepine derivatives, characterized in that it consists of reacting a quinazoline compound of the general formula ** (See formula) ** wherein R1 represents hydrogen, halogen, lower alkyl, lower alkoxy, nitro, trifluoromethyl, cyano or lower alkylthio, R2 represents hydrogen or halogen, R3 represents hydrogen, lower alkyl or lower haloalkyl, R4 represents hydrogen or an alkyl group with 1 to 6 atoms of carbon and X represents halogen, in anhydrous conditions, with one mole, at most, of a strong base per mole of the quinazoline compound, in isomerizing, if desired, a compound obtained, of the general formula ** (See formula) ** where R1, R2, R3 and R4 have the meaning already stated, by applying heat, in treating the compound obtained, of the general formula ** (See formula) ** where R1, R2, R3 and R4 have the meaning stated above, before or after the isomerization, with a reducing agent, in oxidizing the compound thus obtained, of the general formula ** (See formula) ** where R1, R2, R3, and R4 have the meaning set forth above, to obtain a benzodiazepine derivative of the general formula ** (See formula) ** O well ** (See formula) ** and, if desired, in deoxygenating the latter, to obtain the corresponding 4-deoxy derivative, and, if desired, to transform the obtained product into an acid addition salt. (Machine-translation by Google Translate, not legally binding)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US415793A US3398139A (en) | 1964-04-10 | 1964-12-03 | Process for preparing 2-amino-benzodiazepines |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES320302A1 true ES320302A1 (en) | 1966-05-16 |
Family
ID=23647213
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES0320302A Expired ES320302A1 (en) | 1964-12-03 | 1965-12-02 | A procedure for the preparation of benzodiazepine derivatives. (Machine-translation by Google Translate, not legally binding) |
| ES0320301A Expired ES320301A1 (en) | 1964-12-03 | 1965-12-02 | A procedure for the preparation of benzodiazepine derivatives. (Machine-translation by Google Translate, not legally binding) |
| ES0320299A Expired ES320299A1 (en) | 1964-12-03 | 1965-12-02 | A procedure for the preparation of benzodiazepine derivatives. (Machine-translation by Google Translate, not legally binding) |
| ES0320300A Expired ES320300A1 (en) | 1964-12-03 | 1965-12-02 | A procedure for the preparation of quinazoline derivatives. (Machine-translation by Google Translate, not legally binding) |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES0320301A Expired ES320301A1 (en) | 1964-12-03 | 1965-12-02 | A procedure for the preparation of benzodiazepine derivatives. (Machine-translation by Google Translate, not legally binding) |
| ES0320299A Expired ES320299A1 (en) | 1964-12-03 | 1965-12-02 | A procedure for the preparation of benzodiazepine derivatives. (Machine-translation by Google Translate, not legally binding) |
| ES0320300A Expired ES320300A1 (en) | 1964-12-03 | 1965-12-02 | A procedure for the preparation of quinazoline derivatives. (Machine-translation by Google Translate, not legally binding) |
Country Status (2)
| Country | Link |
|---|---|
| AT (1) | AT257617B (en) |
| ES (4) | ES320302A1 (en) |
-
1965
- 1965-09-14 AT AT922266A patent/AT257617B/en active
- 1965-12-02 ES ES0320302A patent/ES320302A1/en not_active Expired
- 1965-12-02 ES ES0320301A patent/ES320301A1/en not_active Expired
- 1965-12-02 ES ES0320299A patent/ES320299A1/en not_active Expired
- 1965-12-02 ES ES0320300A patent/ES320300A1/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| ES320299A1 (en) | 1966-10-01 |
| ES320300A1 (en) | 1966-05-16 |
| AT257617B (en) | 1967-10-10 |
| ES320301A1 (en) | 1966-05-16 |
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