ES310875A1 - A procedure for the preparation of new nitrogenated steroids. (Machine-translation by Google Translate, not legally binding)
- Google Patents
A procedure for the preparation of new nitrogenated steroids. (Machine-translation by Google Translate, not legally binding)
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Sanofi Aventis France
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Roussel Uclaf SA
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Priority claimed from FR968943Aexternal-prioritypatent/FR1512326A/en
Application filed by Roussel Uclaf SAfiledCriticalRoussel Uclaf SA
Publication of ES310875A1publicationCriticalpatent/ES310875A1/en
A process for the preparation of compounds of general formula I: ** (See formula) ** wherein R represents hydrogen, a lower alkyl radical or the acyl radical of a lower organic acid, and salts of said compounds, characterized in that a secondary amine, especially dimethylamine, is condensed on the chloride of beta-5-acid. cholanic esterified in position 3, is obtained with simultaneous saponification the 3 alpha-hydroxy 24-oxo 25-aza 5 beta-cholestane, is subjected to the action of an oxidizing agent, which leads to 3,24-dioxo 25-aza 5 beta-cholestane, the system of two double bonds in positions 1 and 4 is introduced by bromination and dehydromination. The 3,24-dioxo-25-aza-1,4-cholestadiene obtained by 3-hydroxy 24- is aromatized by thermolysis. oxo 25-aza 19-nor 1,3,5 (10) -colestatriene, which, by the action of a reducing agent, provides the 3-hydroxy 25-aza 19-nor 1,3,5 (IO) -colestatriene sought and, when the cas1 is converted, this latter compound is converted into the desired functional derivative of general formula I. (Machine-translation by Google Translate, not legally binding)
ES0310875A1964-03-271965-03-23A procedure for the preparation of new nitrogenated steroids. (Machine-translation by Google Translate, not legally binding)
ExpiredES310875A1
(en)
A procedure for the preparation of 3-or2'-amino tiazolo - (5 ', 4'-16,17) - estra 1,3,5 (10), 16-tetraens. (Machine-translation by Google Translate, not legally binding)