ES298718A1 - Procedure for preparing derivatives of yohimbanos halogen-substitutes of ring e (Machine-translation by Google Translate, not legally binding) - Google Patents

Procedure for preparing derivatives of yohimbanos halogen-substitutes of ring e (Machine-translation by Google Translate, not legally binding)

Info

Publication number
ES298718A1
ES298718A1 ES298718A ES298718A ES298718A1 ES 298718 A1 ES298718 A1 ES 298718A1 ES 298718 A ES298718 A ES 298718A ES 298718 A ES298718 A ES 298718A ES 298718 A1 ES298718 A1 ES 298718A1
Authority
ES
Spain
Prior art keywords
halogen
translation
ring
machine
legally binding
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES298718A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth Holdings LLC
Original Assignee
American Cyanamid Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Cyanamid Co filed Critical American Cyanamid Co
Publication of ES298718A1 publication Critical patent/ES298718A1/en
Expired legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D459/00Heterocyclic compounds containing benz [g] indolo [2, 3-a] quinolizine ring systems, e.g. yohimbine; 16, 18-lactones thereof, e.g. reserpic acid lactone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Photoreceptors In Electrophotography (AREA)

Abstract

"Process for preparing halogen-substituted derivatives of ring E", of general formula ** (See formula) ** wherein R is selected from the group consisting of lower alkyl, phenyl and substituted phenyl, and their tautomers; and its pharmaceutically acceptable, non-toxic, acidic metal anolate and acid addition salts characterized by reacting a yohimban-17-one with a secondary aliphatic amine; and contacting the yohimban-17-enamine thus obtained, with an acid halide of the formula: ** (See formula) ** wherein R is a lower alkyl, phenyl or substituted phenyl group, and X is halogen. (Machine-translation by Google Translate, not legally binding)
ES298718A 1963-05-24 1964-04-15 Procedure for preparing derivatives of yohimbanos halogen-substitutes of ring e (Machine-translation by Google Translate, not legally binding) Expired ES298718A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US28286063A 1963-05-24 1963-05-24

Publications (1)

Publication Number Publication Date
ES298718A1 true ES298718A1 (en) 1964-12-01

Family

ID=23083436

Family Applications (1)

Application Number Title Priority Date Filing Date
ES298718A Expired ES298718A1 (en) 1963-05-24 1964-04-15 Procedure for preparing derivatives of yohimbanos halogen-substitutes of ring e (Machine-translation by Google Translate, not legally binding)

Country Status (9)

Country Link
BE (1) BE645920A (en)
BR (1) BR6458247D0 (en)
CH (1) CH449036A (en)
DE (1) DE1445439A1 (en)
DK (1) DK104940C (en)
ES (1) ES298718A1 (en)
GB (2) GB1012018A (en)
NL (1) NL6403093A (en)
SE (1) SE302615B (en)

Also Published As

Publication number Publication date
NL6403093A (en) 1964-11-25
BE645920A (en) 1964-09-30
GB1012018A (en) 1965-12-08
GB1012019A (en) 1965-12-08
SE302615B (en) 1968-07-29
CH449036A (en) 1967-12-31
DK104940C (en) 1966-07-25
DE1445439A1 (en) 1969-03-06
BR6458247D0 (en) 1973-08-02

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