ES282100A1 - Procedure for the preparation of new steroid compounds (Machine-translation by Google Translate, not legally binding) - Google Patents
Procedure for the preparation of new steroid compounds (Machine-translation by Google Translate, not legally binding)Info
- Publication number
- ES282100A1 ES282100A1 ES282100A ES282100A ES282100A1 ES 282100 A1 ES282100 A1 ES 282100A1 ES 282100 A ES282100 A ES 282100A ES 282100 A ES282100 A ES 282100A ES 282100 A1 ES282100 A1 ES 282100A1
- Authority
- ES
- Spain
- Prior art keywords
- 3alpha
- hydroxy
- 5beta
- bis
- acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J17/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, having an oxygen-containing hetero ring not condensed with the cyclopenta(a)hydrophenanthrene skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J75/00—Processes for the preparation of steroids in general
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Steroid Compounds (AREA)
Abstract
Method of preparation of 1 '' -/3alpha-hydroxy 5beta-androst 9 (11) -one 17beta-and 1/3 ", 5", 8 "- trioxa bicyclo/2,2,2/-octane and of its esters of organic acids that respond to the following general formula: **fórmula** Wherein r represents hydrogen or the acyl radical of a lower organic acid, such as the acetyl radical, characterized in that a 3alpha, 21-diacyloxy-20,20-bis (acyloxymethyl) -lbeta-hydroxy-5-betaethanohydrate is dehydrated in 9-11. Pregnane (II), by means of a dehydrating agent, such as perchloric acid in acetic acid or methane sulfonyl chloride and pyridine in dimethyl formamide, is subjected to 3alpha, 21-diacyloxy 20,20-bis (acyloxymethyl) 5beta -preg 9 (11) -eno (III) obtained at the action of an alkaline agent such as sodium hydroxide solution, the 3alpha is condensed. 21-dihydroxy-20,20-bis- (hydroxy-methyl) -beta-pregn 9 (11) -engine (IV) formed, with a lower alkyl orthoformate in the presence of a catalyst such as p-toluene sulfonic acid, and we obtain the 1 '' -/3alpha-hydroxy 5beta-androst 9 (11) -one 17beta-y 1/3 ", 5", 8 "- trioxa bicyclo/2,2,2/-octane i ( r = h) which can be converted into ester (i, r = acyl radical of a lower organic acid) by means of a lower organic acid or a functional derivative thereof. (Machine-translation by Google Translate, not legally binding)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR877900A FR1699M (en) | 1961-11-03 | 1961-11-03 | New drug, especially for the treatment of spasms of vascular and visceral origin. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES282100A1 true ES282100A1 (en) | 1963-04-01 |
Family
ID=8765992
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES282100A Expired ES282100A1 (en) | 1961-11-03 | 1962-11-02 | Procedure for the preparation of new steroid compounds (Machine-translation by Google Translate, not legally binding) |
Country Status (4)
| Country | Link |
|---|---|
| CH (1) | CH411856A (en) |
| ES (1) | ES282100A1 (en) |
| FR (1) | FR1699M (en) |
| GB (1) | GB988803A (en) |
-
1961
- 1961-11-03 FR FR877900A patent/FR1699M/en active Active
-
1962
- 1962-11-01 CH CH1282262A patent/CH411856A/en unknown
- 1962-11-02 ES ES282100A patent/ES282100A1/en not_active Expired
- 1962-11-05 GB GB41757/62A patent/GB988803A/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| CH411856A (en) | 1966-04-30 |
| FR1699M (en) | 1963-02-18 |
| GB988803A (en) | 1965-04-14 |
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