ES275910A1 - Procedure for the preparation of 3-alpha-aciloxi 11-oxo 20, 20-bis-phosphatomethyl 21-hydroxy 5-beta-pregnan (Machine-translation by Google Translate, not legally binding)
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Procedure for the preparation of 3-alpha-aciloxi 11-oxo 20, 20-bis-phosphatomethyl 21-hydroxy 5-beta-pregnan (Machine-translation by Google Translate, not legally binding)
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Sanofi Aventis France
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Roussel Uclaf SA
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C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
C—CHEMISTRY; METALLURGY
C07—ORGANIC CHEMISTRY
C07J—STEROIDS
C07J75/00—Processes for the preparation of steroids in general
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Steroid Compounds
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Pharmaceuticals Containing Other Organic And Inorganic Compounds
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Abstract
Process for the preparation of the 3alpha-acyloxy 11-oxo-20,20-bis-phosphatomethyl-21-hydroxy-5-beta-pregnanes, of the following general formula, I: ** (See formula) ** in which R represents the acyl radical of an organic acid and, more particularly, the 3alpha-acetoxy-oxo 11 20,20-bis-hydroxy-5beta fosfatometil 21-pregnane (I, R = COCH3 with), characterized in that 3alpha-acyloxy subjected the 11-oxo-20,20-bis-hydroxymethyl 5beta pregnane, to the action of a functional derivative of phosphoric acid such as dibenzyl phosphonate halogen, it is obtained the 20,20-bis-dibenzyl fosfatometil pregnane corresponding, and, in the latter case, the 20,20-bis-dibenzyl phosphatomethyl groups are subjected to hydrogenolysis. (Machine-translation by Google Translate, not legally binding)
ES275910A1961-03-291962-03-28Procedure for the preparation of 3-alpha-aciloxi 11-oxo 20, 20-bis-phosphatomethyl 21-hydroxy 5-beta-pregnan (Machine-translation by Google Translate, not legally binding)
ExpiredES275910A1
(en)
Procedure for the preparation of 3-alpha-aciloxi 11-oxo 20, 20-bis-phosphatomethyl 21-hydroxy 5-beta-pregnan (Machine-translation by Google Translate, not legally binding)
Procedure for the curing and vulcanization by the heat of a copolymer of ethylene - propylene (Machine-translation by Google Translate, not legally binding)
Procedure for the preparation of 3-alpha-aciloxi 11-oxo 20, 20-bis-phosphatomethyl 21-hydroxy 5-beta-pregnan (Machine-translation by Google Translate, not legally binding)
A procedure for preparing the 21-hydroxy steroids of the pregnan series esterified in the position 21. (Machine-translation by Google Translate, not legally binding)