ES268859A1 - Pyrazine derivatives - Google Patents
Pyrazine derivativesInfo
- Publication number
- ES268859A1 ES268859A1 ES0268859A ES268859A ES268859A1 ES 268859 A1 ES268859 A1 ES 268859A1 ES 0268859 A ES0268859 A ES 0268859A ES 268859 A ES268859 A ES 268859A ES 268859 A1 ES268859 A1 ES 268859A1
- Authority
- ES
- Spain
- Prior art keywords
- methyl
- aminopyrazine
- alkyl
- chloro
- hydroxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/20—Nitrogen atoms
- C07D241/22—Benzenesulfonamido pyrazines
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
The invention comprises 3-alkoxy-2-sulphapyrazines of the formula <FORM:0922725/IV(a)/1> wherein R1 and/or R2 are H or alkyl (at least one being alkyl), R3 = H or Ac, R4 = -SO2-C6H4-NHAc, -SO2-C6H4-NH2 or -SO2-C6H4-NO2, Alk represents an alkyl radical of 1-4 carbon atoms and Ac represents an aliphatic monocarboxylic acyl radical of 1-4 carbon atoms and the preparation of these compounds by treating the corresponding aminopyrazine with a p-acylaminobenzene-sulphonyl halide in the presence of a tertiary amine and if desired hydrolysing the resulting p-acylamino-derivative with alkali or acid or by treating the aminopyrazine with a p-nitrobenzenesulphonyl halide and reducing the resulting nitrobenzenesulphonamido-pyrazine with hydrogen in the presence of a hydrogenation catalyst such as palladium/charcoal. Startinb materials. 5-Methyl- 3-chloro-2-aminopyrazine is made by treating 5-methyl-3-hydroxy-2-aminopyrazine with POCl3. 6-Methyl-3-chloro-2-aminopyrazine is made by converting 6-methyl-3-hydroxy- 2-carbamoylpyrazine into 6-methyl-3-hydroxy -2-aminopyrazine by Hoffmann reaction and chlorinating with POCl3. The 5-methyl-3-chloro-2-aminopyrazine may be converted into the 6-methyl-3-chloro-2-aminopyrazine and vice versa by treating successively with nitrous acid to give a 2-hydroxy-3-chloro-(5 or 6)-methyl-pyrazine, ammonia to give 2-hydroxy-3-amino-(5 or 6) methyl-pyrazine, and finally with POCl3.ALSO:Pharmaceutical preparations for treatment of bacterial infections comprise compounds of the formula <FORM:0922725/VI/1> wherein R1 and/or R2 are H or alkyl (at least one being alkyl), R3 = H or Ac, R4 = -SO2-C6H4-NHAc, -SO2-C6H4-NH2 or -SO2 -C6H4-NO2, Alk represents an alkyl radical of 1-4 carbon atoms and Ac represents an aliphatic monocarboxylic acyl radical of 1-4 carbon atoms, optionally admixed with other sulphonamides or antibiotics, and a carrier. The preparations may take the form of powders, tablets, pills or syrups and may be mixed with animal foods.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT1210860 | 1960-07-08 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES268859A1 true ES268859A1 (en) | 1961-12-16 |
Family
ID=11139461
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES0268859A Expired ES268859A1 (en) | 1960-07-08 | 1961-07-07 | Pyrazine derivatives |
Country Status (3)
Country | Link |
---|---|
BE (1) | BE605897A (en) |
ES (1) | ES268859A1 (en) |
GB (1) | GB922725A (en) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE943301C (en) * | 1951-10-17 | 1956-05-17 | Busch Jaeger Duerener Metall | Socket for fluorescent tubes |
CA2209465C (en) * | 1996-07-11 | 2008-04-29 | Lonza Ag | Process for preparing 3-alkoxy-5-alkylpyrazin-2-amines |
CA2241933C (en) * | 1997-07-03 | 2008-10-07 | Lonza Ag | Process for preparing alkoxypyrazine derivatives |
-
1961
- 1961-07-03 GB GB2396861A patent/GB922725A/en not_active Expired
- 1961-07-07 BE BE605897A patent/BE605897A/en unknown
- 1961-07-07 ES ES0268859A patent/ES268859A1/en not_active Expired
Also Published As
Publication number | Publication date |
---|---|
GB922725A (en) | 1963-04-03 |
BE605897A (en) | 1962-01-08 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
MY104375A (en) | Vitamin d derivatives and process for their preparation. | |
GR3025948T3 (en) | Heterocyclic alkylamines, process for their preparation and pharmaceutical compositions containing them | |
ES268859A1 (en) | Pyrazine derivatives | |
GB824908A (en) | Improvements in or relating to triazine derivatives | |
GB962857A (en) | Process for the production of imides | |
ES418743A1 (en) | 4'-deoxyambutyrosin a and b | |
GB1412617A (en) | Substituted aryl and aralkyl amides | |
GB1530921A (en) | Desacylpepsidine and the preparation thereof | |
GB1512101A (en) | Piperazinopyrimidines process for their preparation and use | |
GB1201977A (en) | Penicilloic acid derivatives and a process for the manufacture thereof | |
GB1022935A (en) | Derivatives of dihydro-d-lysergic acid | |
GB859716A (en) | New pyrimidines and their salts and a process for their production | |
GB1184076A (en) | Substituted Phenyl Acetic Acid Amides and Process for their Manufacture | |
GB1045819A (en) | New isoxazoles and process for preparing same | |
ES387934A1 (en) | Process for the preparation of des-phenylalanine b1-insulin | |
GB1173577A (en) | Improvements in or relating to New Indole Derivatives, Process for Preparing same and Therapeutic Compositions Containing them | |
GB985004A (en) | 6-methyl-ergoline i derivatives | |
GB1074468A (en) | Carbalkoxyhtdrazones of the androstane adn estrane series | |
JPS5170769A (en) | 10*111 jihidoro 33 karubokishishipuroheputajin oyobi sono nn okisaido | |
GB1351921A (en) | Nitrofuryl triazolo-pyridazine-amides | |
ES436198A1 (en) | Substituted cephalosporin antibiotics | |
GB1047257A (en) | ||
ES378999A1 (en) | Isoxazolidine derivatives and their method of preparation | |
GB1084343A (en) | ||
GB1022957A (en) | New amidines and process for preparing them |