ES2679373T3 - Nuevos ligandos de RIG-I y métodos para producirlos - Google Patents

Nuevos ligandos de RIG-I y métodos para producirlos Download PDF

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ES2679373T3
ES2679373T3 ES13774100T ES13774100T ES2679373T3 ES 2679373 T3 ES2679373 T3 ES 2679373T3 ES 13774100 T ES13774100 T ES 13774100T ES 13774100 T ES13774100 T ES 13774100T ES 2679373 T3 ES2679373 T3 ES 2679373T3
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sequence
nucleotide
ligands
produce
methods
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Marion GOLDECK
Jasper VAN DEN BOORN
János LUDWIG
Christine SCHUBERTH-WAGNER
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Univ Bonn Rheinische Friedrich Wilhelms
Rheinische Friedrich Wilhelms Universitaet Bonn
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Univ Bonn Rheinische Friedrich Wilhelms
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Abstract

Un oligonucleótido que comprende una hebra sentido y una hebra antisentido, en donde el oligonucleótido comprende una hebra sentido que comprende la secuencia de nucleótidos **(Ver secuencia)** ; y una hebra antisentido que comprende la secuencia de nucleótidos **(Ver secuencia)**; o una hebra sentido que comprende la secuencia de nucleótidos **(Ver secuencia)**; y una hebra antisentido que comprende la secuencia de nucleótidos **(Ver secuencia)**; en donde el nucleótido con subíndice m está 2'-O-metilado; el nucleótido con subíndice f está 2'-fluorado; y el subíndice PTO entre dos nucleótidos indica que dichos dos nucleótidos están unidos por un enlace fosfotioato; y en donde la hebra sentido comprende un trifosfato en el extremo 5'.
ES13774100T 2012-09-27 2013-09-26 Nuevos ligandos de RIG-I y métodos para producirlos Active ES2679373T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP12186444.1A EP2712870A1 (en) 2012-09-27 2012-09-27 Novel RIG-I ligands and methods for producing them
PCT/EP2013/070117 WO2014049079A1 (en) 2012-09-27 2013-09-26 Novel rig-i ligands and methods for producing them

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ES2679373T3 true ES2679373T3 (es) 2018-08-24

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US (3) US10059943B2 (es)
EP (5) EP2712870A1 (es)
JP (1) JP6313768B2 (es)
KR (1) KR102182479B1 (es)
CN (2) CN106279300B (es)
AU (2) AU2013322620C1 (es)
BR (2) BR112015006874B1 (es)
CA (1) CA2885564C (es)
CL (1) CL2015000752A1 (es)
CY (1) CY1120660T1 (es)
DK (1) DK2903997T3 (es)
EA (2) EA034605B1 (es)
ES (1) ES2679373T3 (es)
HK (2) HK1209128A1 (es)
HR (1) HRP20181114T1 (es)
HU (1) HUE038811T2 (es)
IL (1) IL237794B (es)
LT (1) LT2903997T (es)
MX (1) MX2015003787A (es)
NZ (2) NZ736108A (es)
PH (1) PH12015500644A1 (es)
PL (1) PL2903997T3 (es)
PT (1) PT2903997T (es)
RS (1) RS57609B1 (es)
SA (2) SA517380700B1 (es)
SG (3) SG10201912308SA (es)
SI (1) SI2903997T1 (es)
TN (1) TN2015000104A1 (es)
TR (1) TR201810231T4 (es)
UA (1) UA117565C2 (es)
WO (1) WO2014049079A1 (es)
ZA (1) ZA201501718B (es)

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ES2647452T3 (es) 2006-08-08 2017-12-21 Rheinische Friedrich-Wilhelms-Universität Bonn Estructura y uso de oligonucleótidos 5' fosfato
US9738680B2 (en) 2008-05-21 2017-08-22 Rheinische Friedrich-Wilhelms-Universität Bonn 5′ triphosphate oligonucleotide with blunt end and uses thereof
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EP2712870A1 (en) 2012-09-27 2014-04-02 Rheinische Friedrich-Wilhelms-Universität Bonn Novel RIG-I ligands and methods for producing them
US9861574B2 (en) * 2013-04-09 2018-01-09 Duke University 2-fluoro-modified RNAs as immunostimulators
DE102015008536A1 (de) 2015-07-02 2017-01-05 Rheinische Friedrich-Wilhelms-Universität Bonn Diskontinuierliche Oligonukleotid-Liganden
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WO2018187328A1 (en) 2017-04-03 2018-10-11 Duke University Compositions and methods for differential induction of cell death and interferon expression
CN112105733A (zh) 2018-04-19 2020-12-18 查美特制药公司 合成rig-i样受体激动剂
EP3781687A4 (en) 2018-04-20 2022-02-09 Merck Sharp & Dohme Corp. NEW RIG-I SUBSTITUTED AGONISTS: COMPOSITIONS AND METHODS THEREOF
EP3936118A4 (en) * 2019-02-22 2022-12-14 Lemonex Inc. PHARMACEUTICAL COMPOSITION FOR IMMUNE ACTIVITY OR FOR THE PREVENTION OR TREATMENT OF CANCER
WO2020260547A1 (en) 2019-06-27 2020-12-30 Rigontec Gmbh Design method for optimized rig-i ligands
IL309662A (en) 2021-07-02 2024-02-01 Univ Yale Compositions and methods for treating cancer
WO2023034864A1 (en) 2021-08-31 2023-03-09 Yale University Compositions and methods for treating cancers
WO2023168352A1 (en) 2022-03-03 2023-09-07 Yale University Humanized 3e10 antibodies, variants, and antigen binding fragments thereof

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