ES2634683T3 - Método de preparación de cisteína o de un derivado de la misma utilizando una nueva O-fosfoserina sulfhidrilasa - Google Patents

Método de preparación de cisteína o de un derivado de la misma utilizando una nueva O-fosfoserina sulfhidrilasa Download PDF

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Publication number
ES2634683T3
ES2634683T3 ES12858268.1T ES12858268T ES2634683T3 ES 2634683 T3 ES2634683 T3 ES 2634683T3 ES 12858268 T ES12858268 T ES 12858268T ES 2634683 T3 ES2634683 T3 ES 2634683T3
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derivative
new
phosphoserine
phosphoserine sulfhydrylase
derivatives
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ES12858268.1T
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English (en)
Inventor
Byeong Cheol Song
Jin Sook Chang
Jae Hyun Jo
Hye Won Kim
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CJ CheilJedang Corp
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CJ CheilJedang Corp
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/12—Methionine; Cysteine; Cystine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1085—Transferases (2.) transferring alkyl or aryl groups other than methyl groups (2.5)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y205/00—Transferases transferring alkyl or aryl groups, other than methyl groups (2.5)
    • C12Y205/01—Transferases transferring alkyl or aryl groups, other than methyl groups (2.5) transferring alkyl or aryl groups, other than methyl groups (2.5.1)
    • C12Y205/01065—O-Phosphoserine sulfhydrylase (2.5.1.65)

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

Un método de producción de cisteína o de derivados de la misma, que comprende la etapa de hacer reaccionar O-fosfoserina (OPS) como un sustrato con un sulfuro en presencia de O-fosfoserina sulfhidrilasa (OPSS) que tiene una secuencia de aminoácidos representada por SEQ ID NO: 1 o 2, o de un microorganismo que la expresa, produciendo de este modo cisteína o los derivados de la misma, en el que dichos derivados se seleccionan del grupo que consiste en N-acetilcisteína (NAC) y S-carboximetilcisteína (SCMC).

Description

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Claims (1)

  1. imagen1
ES12858268.1T 2011-12-15 2012-12-14 Método de preparación de cisteína o de un derivado de la misma utilizando una nueva O-fosfoserina sulfhidrilasa Active ES2634683T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
KR20110135665 2011-12-15
KR1020110135665A KR101404376B1 (ko) 2011-12-15 2011-12-15 신규 ｏ-포스포세린 설프하이드릴라아제를 이용하여 시스테인 또는 이의 유도체를 생산하는 방법
PCT/KR2012/010900 WO2013089478A2 (ko) 2011-12-15 2012-12-14 신규 ｏ-포스포세린 설프하이드릴라아제를 이용하여 시스테인 또는 이의 유도체를 생산하는 방법

Publications (1)

Publication Number Publication Date
ES2634683T3 true ES2634683T3 (es) 2017-09-28

Family

ID=48613316

Family Applications (1)

Application Number Title Priority Date Filing Date
ES12858268.1T Active ES2634683T3 (es) 2011-12-15 2012-12-14 Método de preparación de cisteína o de un derivado de la misma utilizando una nueva O-fosfoserina sulfhidrilasa

Country Status (12)

Country Link
US (1) US9243268B2 (es)
EP (1) EP2792748B1 (es)
JP (1) JP5860550B2 (es)
KR (1) KR101404376B1 (es)
CN (1) CN104039963B (es)
BR (2) BR112014014762B1 (es)
CA (2) CA2914131C (es)
ES (1) ES2634683T3 (es)
MY (2) MY164371A (es)
PH (1) PH12014501353B1 (es)
RU (1) RU2579689C1 (es)
WO (1) WO2013089478A2 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101677328B1 (ko) * 2014-08-12 2016-11-18 씨제이제일제당 (주) O-포스포세린 생산 미생물 및 이를 이용한 o-포스포세린 또는 l-시스테인 생산 방법
KR101694632B1 (ko) * 2015-09-11 2017-01-10 씨제이제일제당 (주) 신규 ｏ-포스포세린 배출 단백질 변이체 및 이를 이용한 ｏ-포스포세린, 시스테인 및 이의 유도체의 생산방법
KR101825310B1 (ko) 2016-12-29 2018-03-15 씨제이제일제당 (주) O-포스포세린을 생산하는 에스케리키아 속 미생물 및 이를 이용한 o-포스포세린 또는 l-시스테인을 생산하는 방법
KR102025867B1 (ko) 2017-07-13 2019-09-27 씨제이제일제당 주식회사 인산을 발효액 또는 발효 폐액으로부터 회수 및 재사용하는 방법
KR20190092951A (ko) 2018-01-31 2019-08-08 씨제이제일제당 (주) 연속식 크로마토그래피 공정을 이용한 천연 l-시스테인 결정의 제조 방법
KR20190092950A (ko) 2018-01-31 2019-08-08 씨제이제일제당 (주) 연속식 크로마토그래피 공정을 이용한 천연 l-시스테인 염산염 수화물 결정의 제조 방법

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1299128C (en) * 1986-11-19 1992-04-21 Tooru Miyahara Method of producing l-cystine
US6579705B2 (en) 2001-04-04 2003-06-17 Consortium Fur Elektrochemische Industrie Gmbh Process for preparing non-proteinogenic L-amino acids
RU2279477C2 (ru) * 2003-12-05 2006-07-10 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО АГРИ) Мутантная серинацетилтрансфераза, фрагмент днк, кодирующий мутантную серинацетилтрансферазу (варианты), бактерия, принадлежащая к роду escherichia, - продуцент l-цистеина, и способ продукции l-цистеина
DE102004035052A1 (de) * 2004-07-20 2006-02-16 Basf Ag Mikroorganismen zur Herstellung von schwefelhaltigen Verbindungen
JP2006304673A (ja) * 2005-04-28 2006-11-09 National Institute Of Advanced Industrial & Technology システイン合成酵素のホスホセリンに対する基質特異性を高める方法
AU2006261356A1 (en) * 2005-06-17 2006-12-28 Microbia, Inc. Improved amino acid and metabolite biosynthesis
KR101381048B1 (ko) * 2010-10-20 2014-04-14 씨제이제일제당 (주) Ｏ-포스포세린 생산 균주 및 이로부터 생산된 ｏ-포스포세린으로부터 ｌ-시스테인 또는 이의 유도체의 생산방법

Also Published As

Publication number Publication date
PH12014501353A1 (en) 2014-09-22
CA2914131C (en) 2018-05-01
MY164371A (en) 2017-12-15
BR112014014762B1 (pt) 2021-06-29
BR112014014762A8 (pt) 2019-11-19
KR20130068135A (ko) 2013-06-25
JP5860550B2 (ja) 2016-02-16
RU2579689C1 (ru) 2016-04-10
WO2013089478A2 (ko) 2013-06-20
CA2859125C (en) 2018-05-01
JP2015500039A (ja) 2015-01-05
US9243268B2 (en) 2016-01-26
MY176977A (en) 2020-08-28
CN104039963A (zh) 2014-09-10
PH12014501353B1 (en) 2014-09-22
KR101404376B1 (ko) 2014-06-11
WO2013089478A3 (ko) 2013-08-22
BR112014014762A2 (pt) 2018-05-22
CA2859125A1 (en) 2013-06-20
EP2792748A2 (en) 2014-10-22
EP2792748A4 (en) 2015-08-05
CN104039963B (zh) 2016-08-31
BR122019023670B1 (pt) 2021-06-29
CA2914131A1 (en) 2013-06-20
EP2792748B1 (en) 2017-04-26
US20150004657A1 (en) 2015-01-01

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